Fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects

Liu, Jie; Rawlinson, Simon C.F.; Hill, Robert G.; Fortune, Farida

doi:10.1016/j.dental.2016.07.003

Cited by 53 publications

(28 citation statements)

References 95 publications

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“…Apart from promoting rapid fluorapatite formation, it is also shown that fluoride regulates bone-forming cell activities, promotes osteoblasts-like cell pre-osteogenic, pro-angiogenic responses and bone resorption in vitro (14) (15). Moreover, it is also found that fluoride enables to stimulate osteoblast mitosis and bone formation (16).…”

Section: It Should Promote Angiogenesismentioning

confidence: 99%

The effect of the incorporation of fluoride into strontium containing bioactive glasses

Sriranganathan

Chen

Hing

et al. 2017

Journal of Non-Crystalline Solids

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Recently, the porous bioactive glasses have attracted a lot of attention for use as scaffolds for tissue engineering bone, such glasses include the high phosphate, strontium containing glass (Stronbone P TM). However, the previous studies suggest that strontium can have a detrimental effect on the ability of apatite-like phase formation of the glass. The previously studied high phosphate all Sr glass showed an unidentified phase rather than an apatite-like phase upon immersion. Octa-calcium phosphate (OCP) is believed to be a precursor phase to apatite, however octastrontium phosphate does not exist. Fluoride is known to knock out the OCP formation and promotes fluorapatite formation. This work presents the incorporation of a small amount of fluoride into calcium/strontium bioactive glasses. Differential 2 scanning calorimetry was used to estimate the glass thermal properties. All of the studied glass compositions were subjected to bioactivity studies in Tris buffer (pH=7.4) for up to 21 days. The initial glasses and the resultant precipitates were analysed using fourier transform infra red spectroscopy, X-ray diffraction and magic angle spinning-nuclear magnetic resonance. The findings showed that all the fluoride containing glasses were amorphous and there was a marked increase in the rate of apatite formation in vitro compared to the equivalent fluoride free glasses, particularly for the all strontium containing glass. This indicates that the presence of fluoride affects the pathway of apatite formation, forming fluorapatite directly instead of via the transformation from OCP to hydroxyapatite. Therefore, fluoride may have potential future clinical applications as an additive to increase apatite formation.

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Section: It Should Promote Angiogenesismentioning

confidence: 99%

The effect of the incorporation of fluoride into strontium containing bioactive glasses

Sriranganathan

Chen

Hing

et al. 2017

Journal of Non-Crystalline Solids

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“…BG with an amorphous structure can release multiple ions into the oral environment [22][23][24][25], which may help to prevent the demineralization of tooth surfaces surrounding brackets and enhance remineralization after bracket debonding. In the present study, XRD analysis confirmed that the EPD coating process had little influence on the crystal structure of the BG coatings, and these enhanced enamel remineralization.…”

Section: Discussionmentioning

confidence: 99%

Electrophoretic Deposition as a New Bioactive Glass Coating Process for Orthodontic Stainless Steel

et al. 2017

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This study investigated the surface modification of orthodontic stainless steel using electrophoretic deposition (EPD) of bioactive glass (BG). The BG coatings were characterized by spectrophotometry, scanning electron microscopy with energy dispersive X-ray spectrometry, and X-ray diffraction. The frictional properties were investigated using a progressive load scratch test. The remineralization ability of the etched dental enamel was studied according to the time-dependent mechanical properties of the enamel using a nano-indentation test. The EPD process using alternating current produced higher values in both reflectance and lightness. Additionally, the BG coating was thinner than that prepared using direct current, and was completely amorphous. All of the BG coatings displayed good interfacial adhesion, and Si and O were the major components. Most BG-coated specimens produced slightly higher frictional forces compared with non-coated specimens. The hardness and elastic modulus of etched enamel specimens immersed with most BG-coated specimens recovered significantly with increasing immersion time compared with the non-coated specimen, and significant acid-neutralization was observed for the BG-coated specimens. The surface modification technique using EPD and BG coating on orthodontic stainless steel may assist the development of new non-cytotoxic orthodontic metallic appliances having satisfactory appearance and remineralization ability.

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“…They also concluded that the antibacterial action of AgBG is attributed to the leaching of Ag ions from the glass matrix. The study of Liu et al [101] demonstrated that the growths of A. actinomycetemcomitans and P. gingivalis were significantly inhibited by using fluoride-incorporated BGs, and this effect is dose-dependent. Furthermore, strontium-substituted BGs have also been tested to inhibit the growth of A. actinomycetemcomitans and P. gingivalis [102].…”

Section: Bioactive Glassesmentioning

confidence: 99%

Nanoparticles and the control of oral biofilms

Allaker

Yuan

2019

Nanobiomaterials in Clinical Dentistry

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Fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects

Cited by 53 publications

References 95 publications

The effect of the incorporation of fluoride into strontium containing bioactive glasses

The effect of the incorporation of fluoride into strontium containing bioactive glasses

Electrophoretic Deposition as a New Bioactive Glass Coating Process for Orthodontic Stainless Steel

Nanoparticles and the control of oral biofilms

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