The discovery of Epstein-Barr virus (EBV) as the first virus implicated as the causative agent of human cancer was both paradigm shifting and a result of one of the most intriguing, international medical detective stories of the 20 th century. This story begins in Africa with Denis Burkitt, a one-eyed, Protestant Irish surgeon who, after his service with the Royal Army Medical Corps in Kenya and Somaliland during World War II, established a medical practice in Uganda to help the people of Uganda "both medically and spiritually" (1). In 1958, Burkitt described an aggressive tumor of the jaw and face that was common to children living across central Africa (2). Although initially the apparent restriction to the jaw