Folic acid conjugated bovine serum albumin: An efficient smart and tumor targeted biomacromolecule for inhibition folate receptor positive cancer cells

Nosrati, Hamed; Abbasi, Reza; Charmi, Jalil; Rakhshbahar, Akram; Aliakbarzadeh, Faezeh; Danafar, Hossein; Davaran, Soodabeh

doi:10.1016/j.ijbiomac.2018.06.026

Cited by 89 publications

(40 citation statements)

References 32 publications

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“…Unlike chemical drugs, biological macromolecules have the characteristics of large molecular weight, complex structure and biological functions; however, because of these characteristics, regulating the stability and permeability of biomacromolecules is challenging [85]. Therefore, such drugs are transported by a variety of nanometer DDSs [86,87], among which nanogels, composed of nanometer hydrogels, have an excellent drug-loading capacity, stability and hydrophilicity and the potential to be good carriers [88].…”

Section: Biomacromolecule Deliverymentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Reactions or the cleavage of chemical bonds in the structure of drug-loaded nanogels have been shown to trigger the controlled or sustained drug release. Through the design of specific chemical structures and different methods of production, nanogels can realize diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), and enable the stimuli-responsive release of drugs in the microenvironments of various diseases. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. Consequently, the targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.

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Section: Biomacromolecule Deliverymentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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“…Subsequently, the PTX-VE NPs was formed by the interaction among the PTX, VE, and BSA. Both PTX and VE have high affinity with albumin [ 34 , 35 ], the PTX and VE can bound tightly to BSA via hydrophobic interactions and hydrogen bond, which were in favor of the formation of PTX-VE NPs.…”

Section: Resultsmentioning

confidence: 99%

VE-Albumin Core-Shell Nanoparticles for Paclitaxel Delivery to Treat MDR Breast Cancer

Tang

Gou

et al. 2018

Molecules

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Multi-drug resistance (MDR) presents a serious problem in cancer chemotherapy. In this study, Vitamin E (VE)-Albumin core-shell nanoparticles were developed for paclitaxel (PTX) delivery to improve the chemotherapy efficacy in an MDR breast cancer model. The PTX-loaded VE-Albumin core-shell nanoparticles (PTX-VE NPs) had small particle sizes (about 100 nm), high drug entrapment efficiency (95.7%) and loading capacity (12.5%), and showed sustained release profiles, in vitro. Docking studies indicated that the hydrophobic interaction and hydrogen bonds play a significant role in the formation of the PTX-VE NPs. The results of confocal laser scanning microscopy analysis demonstrated that the cell uptake of PTX was significantly increased by the PTX-VE NPs, compared with the NPs without VE (PTX NPs). The PTX-VE NPs also exhibited stronger cytotoxicity, compared with PTX NPs with an increased accumulation of PTX in the MCF-7/ADR cells. Importantly, the PTX-VE NPs showed a higher anti-cancer efficacy in MCF-7/ADR tumor xenograft model than the PTX NPs and the PTX solutions. Overall, the VE-Albumin core-shell nanoparticles could be a promising nanocarrier for PTX delivery to improve the chemotherapeutic efficacy of MDR cancer.

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“…Finally, carboxylic acid groups of BSA‐TAX were activated by EDC‐NHS and CLO conjugated to the BSA‐TAX. The CLO‐BSA‐TAX formulation was prepared and unreacted reagents were removed by extensive dialysis (Nosrati et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

Cholesterol‐conjugated bovine serum albumin nanoparticles as a tamoxifen tumor‐targeted delivery system

Gharbavi

Johari

Eslami

et al. 2020

Cell Biology International

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In the present study, we introduced cholesterol (CLO)‐conjugated bovine serum albumin nanoparticles (BSA NPs) as a new system for indirect targeting drug delivery. Tamoxifen, as an anticancer drug, was loaded on BSA NPs (BSA‐TAX NPs); CLO was then conjugated to the BSA‐TAX NPs surface for the targeted delivery of NPs system, by 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide/N‐hydroxy succinimide carbodiimide chemistry (CLO‐BSA‐TAX NPs). The physicochemical properties, toxicity, in vitro, and in vivo biocompatibility of the BSA NPs system were characterized on cancer cell lines (4T1). The results revealed that the BSA NPs system has a regular spherical shape and negative zeta‐potential values. The drug release of BSA NPs system has shown controlled and pH‐dependent drug release behavior. BSA NPs system was biocompatible but it was potentially toxic on the cancer cell line. The CLO‐BSA‐TAX NPs exhibited higher toxicity against cancer cell lines than other NPs formulation (BSA NPs and BSA‐TAX NPs). It can be concluded that the CLO, as an indirect targeting agent, enhances the toxicity and specificity of NPs system on cancer cell lines. It could potentially be suitable approaches to targeting the tumors in clinical cancer therapy.

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Folic acid conjugated bovine serum albumin: An efficient smart and tumor targeted biomacromolecule for inhibition folate receptor positive cancer cells

Cited by 89 publications

References 32 publications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

VE-Albumin Core-Shell Nanoparticles for Paclitaxel Delivery to Treat MDR Breast Cancer

Cholesterol‐conjugated bovine serum albumin nanoparticles as a tamoxifen tumor‐targeted delivery system

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