Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy

Huang, Peng; Bao, Le; Zhang, Chunlei; Lin, Jing; Luo, Teng; Yang, Da‐Peng; Meng, He; Li, Zhiming; Gao, Guo; Gao, Bing; Fu, Shanlin; Cui, Daxiang

doi:10.1016/j.biomaterials.2011.08.086

Cited by 397 publications

(298 citation statements)

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“…One is transverse plasmon band, relating to the absorption and scattering of light along short axis of rods, located in the visible region at ca. 520 nm, and the other is called longitudinal plasmon band, relating to the absorption and scattering of light along long axis of rods, located in the near-infrared region (NIR) of electromagnetic spectrum which is tunable by changing the aspect of GNRs [23][24][25]. Because biological tissues are relatively transparent in NIR; therefore, gold nanorods-based theranostic agents for multi-modality imaging and photodynamic and photothermal therapy of tumor own obvious advantages over biological tissues, and have been actively investigated their application.…”

Section: Introductionmentioning

confidence: 99%

EGFR Antibody Conjugated Bimetallic Au@Ag Nanorods for Enhanced SERS-Based Tumor Boundary Identification, Targeted Photoacoustic Imaging and Photothermal Therapy

Chen¹,

Zhang²,

Yang³

et al. 2016

Nano BioMed ENG

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The development of multifunctional nanoprobes for simultaneous targeted imaging, tumor boundary identification and photothermal therapy of gastric cancer has become a great challenge. Herein, EGFR monoclonal antibody-conjugated Au@Ag nanorods decorated with DTNB nanoprobes (5,5'-Dithiobis-(2-nitrobenzoic acid)) (EGFR-Au@Ag NR nanotags) were prepared and characterized. Their biocompatibility was analyzed by MTT assay. In vitro studies show that EGFR-Au@Ag NR nanotags own good biocompatibility and capability of targeting and entering into gastric cancer MGC803 cells, silver nano-film layer on the surface of gold nanorods remarkably enhance surfaceenhanced rama spectra (SERS) signal, enhanced photoacoustic imaging efficacy and photothermal conversion efficiency of gold nanorods. In vivo studies show that prepared nanotags could target actively gastric cancer cells at 2 h post-injection, and distributed in the tumor site, exhibited enhanced SERS signals to display clearly tumor boundary, enhanced photoacoustic imaging to display clearly tumor boundary. Under 1 w/cm 2 laser irradiation, tumor growth was remarkably inhibited by local photothermal therapy. In conclusion, high performance EGFR-antibody conjugated Au@Ag nanorod-DTNB nanoprobes exhibit great potential in applications such as targeted photoacoustic imaging, simultaneous tumor boundary identification and selective photothermal therapy of gastric cancer in the near future.

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Section: Introductionmentioning

confidence: 99%

EGFR Antibody Conjugated Bimetallic Au@Ag Nanorods for Enhanced SERS-Based Tumor Boundary Identification, Targeted Photoacoustic Imaging and Photothermal Therapy

Chen¹,

Zhang²,

Yang³

et al. 2016

Nano BioMed ENG

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“…Due to their nanoscale dimensions and high aspect ratio, single-walled carbon nanotubes Other important areas in which multimodal NPs can be beneficial include (i) tumor imaging for guided surgery, [323,[513][514][515][516] imaging of gene expression in vivo to elucidate disease development, [287,288,296,370,[517][518][519][520] drug delivery [471] and efficacy of anti-cancer drugs [234,337,429,498,[521][522][523][524][525].…”

Section: Perspectives: Multimodal Theranostic Npsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…Following laser irradiation, malignant cells were killed at about half of the laser influence needed to kill the nonmalignant cells. Huang et al [74] carried out in vitro dark field mode microscopy imaging, photothermal therapy and in vivo X-ray CT imaging using folate-conjugated GNRs. Zhang et al [75] developed mesoporous silica-coated GNRs as a novel cancer theranostic platform.…”

Section: Gnrs In Theranosticsmentioning

confidence: 99%

Applications of gold nanorods in biomedical imaging and related fields

Hong-xing

Liu

et al. 2013

Chin. Sci. Bull.

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Gold nanorods (GNRs) have great potential widespread applications in biomedical imaging, drug delivery and photothermal therapy due to unique surface plasmon resonance (SPR) ranging from visible to near infrared (NIR) region, facile synthesis and easy functionalization. In this review, the recent progress of GNRs in bioimaging, drug delivery, photothermal therapy and theranostics is summarized and the recommendations for the future work on GNRs are also covered.

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Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy

Cited by 397 publications

References 50 publications

EGFR Antibody Conjugated Bimetallic Au@Ag Nanorods for Enhanced SERS-Based Tumor Boundary Identification, Targeted Photoacoustic Imaging and Photothermal Therapy

EGFR Antibody Conjugated Bimetallic Au@Ag Nanorods for Enhanced SERS-Based Tumor Boundary Identification, Targeted Photoacoustic Imaging and Photothermal Therapy

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Applications of gold nanorods in biomedical imaging and related fields

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