Folic acid-functionalized <scp>l</scp>-cys/ZnS:O nanoparticles for homologous targeting and photodynamic therapy of tumor cells

Wang, Xiaoxuan; Wei, Wenying; Zheng, Dongfang; Chen, Zhong; Dai, Hanren

doi:10.1039/d2tb00719c

Cited by 5 publications

(5 citation statements)

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“…With advances in science and technology, phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), and a combination of noninvasive therapies, have shown unique potential in antibacterial, antitumor, and arthritis treatment. [141][142][143][144][145][146][147][148] Under light irradiation, photosensitizers convert light into heat or produce ROS to promote necrosis or apoptosis of inflammatory cells associated with arthritis, thereby reducing the concentration of associated inflammatory factors and relieving arthritic symptoms. [149,150] As an emerging technology for diagnosis and treatment, FL imaging and phototherapy are becoming a common clinical modality for diagnosis and treatment.…”

Section: Phototherapymentioning

confidence: 99%

Emerging advances in fluorescence imaging and phototherapy of arthritis

Wang,

Dai,

Shao

et al. 2023

Interdisciplinary Materials

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Arthritis is a chronic disease whose etiology is difficult to pinpoint, and the difficulty of arthritis detection and subsequent treatment causes enormous distress to patients. In recent years, thanks to advances in medicine and detection, a variety of treatment modalities for arthritis have emerged. The combination of emerging detection technologies with different anti‐inflammatory medications and even advances in surgical techniques have all played a positive role in the treatment of arthritis. In the present work, we have collected relevant literature on fluorescence (FL) imaging and phototherapy of arthritis in recent years, intending to reveal the advantages and potential application value of FL imaging and phototherapy for researchers. Meanwhile, due to the shortcomings of FL imaging and phototherapy in the diagnosis and treatment of arthritis, we advocate overcoming these difficulties in future research.

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Section: Phototherapymentioning

confidence: 99%

Emerging advances in fluorescence imaging and phototherapy of arthritis

Wang,

Dai,

Shao

et al. 2023

Interdisciplinary Materials

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“…Fluorescence imaging as a non-invasive technique has been widely used in the biomedical field due to its simple operation, high signal-to-noise ratio and high spatiotemporal resolution. [35][36][37][38] With this in mind, many biological processes can be observedin situ . While, conventional organic fluorophores with planar structures often experience notorious aggregation-induced quenching (ACQ) emission in the aggregated state, which limits their biological applications.…”

Section: Introductionmentioning

confidence: 99%

In Situ Imaging and Anti-inflammation of 3D Printed Scaffolds enabled by AIEgen

Wang

Chen

et al. 2023

Preprint

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Three-dimensional (3D) printed bioactive scaffolds have been widely used in the field of bone tissue engineering. However, its visualization in vivo and bacterial inflammation are intractable issues during the surgery and treatment. Herein, we firstly synthesized an aggregation-induced emission-active luminogen (AIEgen), named as 4BC, with efficient reactive oxygen species (ROS) generation. Then, a series of 3D bioactive scaffolds loading 4BC were fabricated by precipitation adsorption method, namely 4BC@scaffolds, which showed good in situ imaging performance for the implanted scaffolds by using simple UV light irradiation. Among them, 4BC@TMP scaffold composed of trimagnesium phosphate (TMP) had an excellent bactericidal ability for E. coli and S. aureus in vitro and resisted bacterial inflammation in vivo through photodynamic action. H&E and immunofluorescence staining were performed to further evaluate the inhibitory effect of bacterial inflammation in vivo. This work verified that AIEgen-based 3D scaffolds are promising bioactive frameworks for bioimaging and antibacterial application.

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“…Fluorescence imaging as a non-invasive technique has been widely used in the biomedical field due to its simple operation, high signal-to-noise ratio, and high spatiotemporal resolution. − With this in mind, many biological processes can be observed in situ. While conventional organic fluorophores with planar structures often experience notorious aggregation-induced quenching (ACQ) emission in the aggregated state, which limits their biological applications.…”

Section: Introductionmentioning

confidence: 99%

In Situ Imaging and Anti-inflammation of 3D Printed Scaffolds Enabled by AIEgen

Wang

Chen

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

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Three-dimensional (3D) printed bioactive scaffolds have been widely used in the field of bone tissue engineering. However, its in vivo visualization and bacterial inflammation are intractable issues during the surgery and treatment. Herein, we first synthesized an aggregation-induced emission-active luminogen (AIEgen) named 4BC with efficient reactive oxygen species (ROS) generation. Then, a series of 3D bioactive scaffolds loaded with 4BC were fabricated by a precipitation adsorption method, namely 4BC@scaffolds, which showed good in situ imaging performance for the implanted scaffolds by using simple UV light irradiation. Among them, the 4BC@TMP scaffold composed of trimagnesium phosphate (TMP) had excellent bactericidal ability for Escherichia coli and Staphylococcus aureus in vitro and resisted bacterial inflammation in vivo through photodynamic action. H&E and immunofluorescence staining were performed to further evaluate the inhibitory effect of bacterial inflammation in vivo. This work verified that AIEgen-based 3D scaffolds are promising bioactive frameworks for bioimaging and antibacterial applications.

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Folic acid-functionalized l-cys/ZnS:O nanoparticles for homologous targeting and photodynamic therapy of tumor cells

Abstract: The marriage of photodynamic therapy (PDT) and fluorescence imaging provides a promising approach to theranostics. However, traditional photosensitizers (PSs) have low water solubility and lack active targeting ability. Our ingenious...

Cited by 5 publications

References 32 publications

Emerging advances in fluorescence imaging and phototherapy of arthritis

Emerging advances in fluorescence imaging and phototherapy of arthritis

In Situ Imaging and Anti-inflammation of 3D Printed Scaffolds enabled by AIEgen

In Situ Imaging and Anti-inflammation of 3D Printed Scaffolds Enabled by AIEgen

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