Follicular fluid anti-Müllerian hormone and inhibin B concentrations: comparison between gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist cycles

Lee, Jung Ryeol; Kim, Seok Hyun; Kim, Sun Mie; Jee, Byung Chul; Ku, Seung Yup; Suh, Chang Suk; Choi, Young Min; Kim, Jung Gu; Moon, Shin Yong

doi:10.1016/j.fertnstert.2007.04.010

Cited by 39 publications

(25 citation statements)

References 55 publications

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“…Hattori et al,investigated FF AMH levels in 58 women attending ICSI-ET cycle with mixed infertility etiology. They reported significantly high FF AMH levels in women became pregnant compared to that in non-pregnant [23] [29]. But in our study; FF AMH level of GnRH agonist users was significantly lower than that of GnRH antagonist users.…”

Section: Discussioncontrasting

confidence: 78%

What is the impact of serum and follicular fluid BMP-15 and AMH levels in ICSI-ET cycle outcomes?

Ilhan¹,

Özkan²,

Ekinci³

et al. 2017

Histol Cytol Embryol

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Objective: Bone morphogenetic protein-15 (BMP-15) and anti-Müllerian hormone (AMH) are the proteins functioning during ovarian follicular growth. We aimed to investigate the impact of serum and follicular fluid (FF) AMH and BMP-15 levels on outcomes of intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycles.Methods: This prospective, cross-sectional study was carried out with 82 patients attending ICSI-ET cycle. The women divided into two groups according to using either GnRH agonist (group1, N=38) or antagonist (group2, N=44) for pituitary down-regulation. Eight milliliter of serum samples were taken from the patients on the 3rd day of menstrual period (D3) and on the day of oocyte pick-up (OPU); and 8 mL of follicular fluid (FF) sample was collected during OPU. AMH and BMP-15 measurements were carried with ELISA method quantitatively. Results:The mean age and body mass index of population were 30.6 ± 5.2 years and 25.5±4.2 kg/m 2 respectively. The comparison of pregnancy rates between women according to having FF AMH (35% vs 42%) and FF BMP-15 (37.8% vs 40.5%) levels under and above of the mean values revealed no significant difference. Serum AMH levels showed negative correlation with fertilization rate (FR). D3 BMP-15 level showed positive correlation with progesterone level and endometrial thickness on the day of hCG injection.Conclusions: AMH and BMP-15 monitoring during ICSI-ET cycles for predicting cycle outcomes should be evaluated with further studies.

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Section: Discussioncontrasting

confidence: 78%

What is the impact of serum and follicular fluid BMP-15 and AMH levels in ICSI-ET cycle outcomes?

Ilhan¹,

Özkan²,

Ekinci³

et al. 2017

Histol Cytol Embryol

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“…Furthermore, since it has been suggested that serum inhibin B in relation to male and female reproductive health have been published internationally and the risk of leukemia that may spread to other organs like ovary (Ahmed et al, 2001;Wen et al, 2006;Lee et al, 2008;Moos et al, 2009;Taflan et al, 2011;Dillon and Gracia, 2012), the present study attempt to clarify the correlation between inhibin and serum protein, glutathione and the two vitamins E and C in patients with ALL, the results were reanalyzed by using linear regression analysis, Table 2.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Inhibin and Several Antioxidants in Children with Acute Lymphoblastic Leukemia

Mehde¹,

Mehdi²,

Zainulabdeen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Acute lymphoblastic leukemia (ALL) is most common in childhood. Inhibin (a non-steroidal glycoprotein hormone of gonadal origin) can be used as marker of fertility. The current study was conducted to evaluate inhibin levels in ALL patients and to estimate its correlation with some antioxidants in these in comparison with control subjects. Materials and Methods: This study was conducted on sixty patients with ALL and thirty children as controls. Fasting blood samples were taken from each subject and analyzed for haemoglobin, serum protein, vitamin E and C, in addition to glutathione and inhibin. Results: The results of the study showed highly significant decreases (p<0.001) in haemoglobin, glutathione and inhibin levels with significant decreases (p<0.05) in serum protein and vitamin E levels for patients group in comparison with controls while there was no significant differences in vitamin C. Moreover, there were significant correlations between inhibin levels and serum protein, glutathione and both vitamins (E and C) in the ALL patient group (r= 0.81, 0.80, 0.77 and 0.69, respectively). Conclusions: The present results indicated infertility in patients with ALL demonstrated by low inhibin level as a consequence of abnormality in anti-oxidative metabolism due to the cancer process. So, it can be suggested the need for routine measurement of inhibin for leukemic patients to estimate the action of hormones of gonadal origin.

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“…Only a few studies have tried to investigate the possible relationship between AMH and ovarian steroidogeneis with inconclusive results (31,32,70).…”

Section: Discussionmentioning

confidence: 99%

Gonadotropin releasing hormone antagonists suppress aromatase and anti-Müllerian hormone expression in human granulosa cells

Winkler

Bükülmez

Hardy

et al. 2010

Fertility and Sterility

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Follicular fluid anti-Müllerian hormone and inhibin B concentrations: comparison between gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist cycles

Cited by 39 publications

References 55 publications

What is the impact of serum and follicular fluid BMP-15 and AMH levels in ICSI-ET cycle outcomes?

What is the impact of serum and follicular fluid BMP-15 and AMH levels in ICSI-ET cycle outcomes?

Correlation of Inhibin and Several Antioxidants in Children with Acute Lymphoblastic Leukemia

Gonadotropin releasing hormone antagonists suppress aromatase and anti-Müllerian hormone expression in human granulosa cells

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