Follicular T helper cells and humoral reactivity in kidney transplant patients

Graav, Gretchen N. de; Dieterich, M.; Hesselink, Dennis A.; Boer, Karin; Groningen, Marian C. Clahsen-van; Kraaijeveld, Rens; Litjens, Nicolle H.R.; Bouamar, Rachida; Vanderlocht, Joris; Tilanus, Marcel G.J.; Houba, I.; Boonstra, André; Roelen, Dave L.; Claas, Frans H.J.; Betjes, Michiel G. H.; Weimar, Willem; Baan, Carla C.

doi:10.1111/cei.12576

Cited by 103 publications

(125 citation statements)

References 42 publications

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“…[5][6][7] The requirement of T-cell help for B-cell antibody production was first described in the late sixties. 8,9 CD4 Tfh cells of the secondary lymphoid organs are now recognized as the immune cells that are responsible for orchestrating the molecular interactions that provide help to B cells.…”

Section: Introductionmentioning

confidence: 99%

T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway

et al. 2016

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Section: Introductionmentioning

confidence: 99%

T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway

et al. 2016

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“…In addition, in the patients with chronic renal allograft rejection, increased circulating Tfh-cell ratio and decreased PD-1 expression were observed36. Furthermore, in the kidney biopsies taken during rejection, researchers found that the Tfh cells co-localized with CD20 + B cells and immunoglobulins in follicular-like structures, suggesting that Tfh cells might act as a bridge between cellular and humoral reactivity in acute rejection of kidney transplantation37.…”

Section: Discussionmentioning

confidence: 99%

Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage-induced abortion

Zeng

Liu

Zhang

et al. 2016

Sci Rep

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A deeper understanding of the immunological events during pregnancy will provide novel insights into the pathogenesis of pregnancy complications. The fundamental function of T follicular helper (Tfh) cells is to provide cognate help to B cells. Dysregulations of Tfh-cell function and/or development can result in various immunological diseases. However, the role and characteristics of Tfh cells during pregnancy remain unknown. Herein, an allogeneic-normal-pregnant mouse model was used, and we found that the CD4+ T cells residing at the uterus and placenta (UP) displayed a Tfh-like phenotype; and the UP-derived CD4+CXCR5hiPD-1hi and CD4+CXCR5hiICOShi Tfh cells, which showed a memory/activation phenotype, reached their peak at mid-pregnancy. These Tfh cells were located abundantly in the uterus at mid-pregnancy, but greatly increased in the placenta at late-pregnancy. Furthermore, increased foetal resorption by PDL1 blockade correlated with enhanced accumulation of Tfh cells and upregulated expressions of ICOS and PD-1 on these cells. Collectively, our findings are the first to indicate that an adequate and balanced accumulation of Tfh cells during gestation is likely to help maintaining a successful pregnancy, whereas an excessively high level of these cells could lead to abortion.

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“…Baan and colleagues examined the kidney biopsies that were obtained from recipients with ongoing renal allograft failure and found that Tfh cells and B cells co-localized (119), indicating Tfh cells could trigger alloantigen-specific antibody production by B cells. Using a mouse model of allogeneic hematopoietic stem cell transplantation, Blazar and colleagues revealed that Tfh cells are required for chronic graft-versus-host disease (cGVHD) in mice (120).…”

Section: Mainmentioning

confidence: 99%

Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection

Jeon

Choi

2016

Immune Netw

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Production of high affinity antibodies for antigens is a critical component for the immune system to fight off infectious pathogens. However, it could be detrimental to our body when the antigens that B cells recognize are of self-origin. Follicular helper T, or Tfh, cells are required for the generation of germinal center reactions, where high affinity antibody-producing B cells and memory B cells predominantly develop. As such, Tfh cells are considered as targets to prevent B cells from producing high affinity antibodies against self-antigens, when high affinity autoantibodies are responsible for immunopathologies in autoimmune disorders. This review article provides an overview of current understanding of Tfh cells and discusses it in the context of animal models of autoimmune diseases and allograft rejections for generation of novel therapeutic interventions.

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Follicular T helper cells and humoral reactivity in kidney transplant patients

Abstract: Summary Memory

Cited by 103 publications

References 42 publications

T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway

T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway

Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage-induced abortion

Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection

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