Food bioactives: the food image behind the curtain of health promotion and prevention against several degenerative diseases

Adefegha, Stephen A.; Oboh, Ganiyu; Oluokun, Odunayo O.

doi:10.1016/b978-0-12-823944-5.00012-0

Cited by 11 publications

(3 citation statements)

References 132 publications

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“…Dietary antioxidants have received increasing interest among scientists, manufacturers, and consumers due to their potential health benefits against many non-communicable diseases. Over the years, dietary (poly)phenols, particularly flavonoids, have been widely studied and reviewed for their physiological benefits, including their role as antioxidants in cancer chemopreventive agents [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. In this study, we investigated the efficacy of selected flavonoids in comparison to flavonoid metabolites, phenolic acids, simple (poly)phenols, stilbenes, curcuminoids, and non-phenolic antioxidants in reducing carcinogen-induced DNA damage in normal lung epithelial BEAS-2B cells.…”

Section: Discussionmentioning

confidence: 99%

Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in Bronchial Epithelial Cells In Vitro

Suraweera

Merlin

Dellaire

et al. 2023

IJMS

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Cancer is one of the leading causes of death worldwide. Chemotherapy and radiation therapy are currently providing the basis for cancer therapies, although both are associated with significant side effects. Thus, cancer prevention through dietary modifications has been receiving growing interest. The potential of selected flavonoids in reducing carcinogen-induced reactive oxygen species (ROS) and DNA damage through the activation of nuclear factor erythroid 2 p45 (NF-E2)-related factor (Nrf2)/antioxidant response element (ARE) pathway was studied in vitro. Dose-dependent effects of pre-incubated flavonoids on pro-carcinogen 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone (NNKAc)-induced ROS and DNA damage in human bronchial epithelial cells were studied in comparison to non-flavonoids. The most effective flavonoids were assessed for the activation of Nrf2/ARE pathway. Genistein, procyanidin B2 (PCB2), and quercetin significantly suppressed the NNKAc-induced ROS and DNA damage. Quercetin significantly upregulated the phosphorylated protein kinase B/Akt. PCB2 significantly upregulated the activation of Nrf2 and Akt through phosphorylation. Genistein and PCB2 significantly upregulated the phospho-Nrf2 nuclear translocation and catalase activity. In summary, genistein and PCB2 reduced the NNKAc-induced ROS and DNA damage through the activation of Nrf2. Further studies are required to understand the role of dietary flavonoids on the regulation of the Nrf2/ARE pathway in relation to carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in Bronchial Epithelial Cells In Vitro

Suraweera

Merlin

Dellaire

et al. 2023

IJMS

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“…Bioactive compounds can be found in different foods, food products, and herbal samples. [30]. Its antioxidant action combats free radicals naturally produced through oxidation which, characteristically, reacts with DNA, RNA, proteins, and other substances possessing oxidative power, causing health damage, and contributing to aging and predisposition to degenerative diseases, such as cancer, atherosclerosis, rheumatic arthritis, besides preventing cardiovascular disease, type 2 diabetes [31,32].…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Análise comparativa dos compostos bioativos do rizoma de açafrão in natura (Curcuma longa L.) e seu condimento comercial em pó

Valente de Freitas,

Carvalho,

Silveira

et al. 2023

Sci. Plena

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O açafrão é um rizoma de alto consumo na forma de condimento em pó. No entanto, suas etapas de processamento podem levar a perdas de compostos bioativos. Nesse contexto, o objetivo principal desta pesquisa foi comparar o teor de compostos bioativos do açafrão in natura e seco (condimento em pó comercial) Curcuma Longa L. A metodologia foi baseada nas Normas Analíticas do Instituto Adolfo Lutz e em referências analíticas publicadas internacionalmente na área de ciência e tecnologia de alimentos. Os resultados mostraram que o açafrão in natura sofre perdas consideráveis durante o processamento para sua conversão em pó comercial. As perdas de 20% na quantidade de compostos fenólicos no pó comercial (de 485,34 ± 43,08 GAE g-1 no açafrão in natura para uma média de 375,72 ± 25,77 GAE g-1 no pó comercial), seguindo comportamento semelhante nos teores de carotenoides (média de 574,41 ± 42,81 g-1 para o açafrão in natura e média de 557 0,27 ± 41,34 g-1 para pó). Diferindo nos valores bioativos para teores de flavonoides com teores maiores para o pó comercial (média de 179,33 e 165,56), maiores em antocianinas 165,56 ± 0,82 e 130,31±0,13 g CE 100 g-1. Medidas de infravermelho mostraram que o processamento não altera os compostos químicos mais termorresistentes, ao contrário dos bioativos. Na análise morfológica, observa-se a presença de amiloplastos e feixes fibrosos, com grânulos de amido aderidos. Esses dados mostram o efeito do processamento desse rizoma e o potencial do açafrão como coadjuvante à saúde humana.

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“…Terpenoids otherwise known as isoprenoids are a large and diverse class of naturally occurring compounds derived from five carbon isoprene units (Reyes et al, 2018). Terpenoids are classified as hemiterpenes (C5), monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), sesterterpenes (C25), triterpenes (C30), and tetraterpenes/carotenoids (C40) (Adefegha et al, 2022). Compound 141 (Figure 9), which was characterized as a new fusicoccane diterpene and named pinophicin A, was obtained from the endophytic fungus T. pinophilus collected from the aerial parts of Salvia miltiorrhiza in 2019 (Zhao et al, 2021a).…”

Section: Terpenoidsmentioning

confidence: 99%

Research advances in the structures and biological activities of secondary metabolites from Talaromyces

et al. 2022

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The genus Talaromyces belongs to the phylum Ascomycota of the kingdom Fungi. Studies have shown that Talaromyces species yield many kinds of secondary metabolites, including esters, terpenes, steroids, alkaloids, polyketides, and anthraquinones, some of which have biological activities such as anti-inflammatory, bacteriostatic, and antitumor activities. The chemical constituents of fungi belonging to the genus Talaromyces that have been studied by researchers over the past several years, as well as their biological activities, are reviewed here to provide a reference for the development of high-value natural products and innovative uses of these resources.

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Food bioactives: the food image behind the curtain of health promotion and prevention against several degenerative diseases

Cited by 11 publications

References 132 publications

Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in Bronchial Epithelial Cells In Vitro

Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in Bronchial Epithelial Cells In Vitro

Análise comparativa dos compostos bioativos do rizoma de açafrão in natura (Curcuma longa L.) e seu condimento comercial em pó

Research advances in the structures and biological activities of secondary metabolites from Talaromyces

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