Food hypersensitivity reactions to seafish in atopic dermatitis patients older than 14 year of age – The evaluation of association with other allergic diseases and parameters

Čelakovská, Jarmila; Bukač, Josef; Vaněčková, J.; Krčmová, Irena; Komorousová, Michaela; Cetkovská, Petra; Vaňková, R.; Krejsek, Jan

doi:10.4103/ijd.ijd_403_18

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…These two allergens were not included in the main results of this study as they were identified from plant and fungi species (Triticum aestivum and Aspergillus fumigatus) that are phylogenetically distant to shrimps. However, there is emerging evidence of patients suffering from shrimp allergy also being sensitised to plant and fungi allergens [25,26]. The allergen cyclophilin is generally found in dust mite, fungi and plants, and demonstrates strong IgE-binding [63,78].…”

Section: Discussionmentioning

confidence: 99%

Novel Allergen Discovery through Comprehensive De Novo Transcriptomic Analyses of Five Shrimp Species

Karnaneedi

Huerlimann

Johnston

et al. 2020

IJMS

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Shellfish allergy affects 2% of the world’s population and persists for life in most patients. The diagnosis of shellfish allergy, in particular shrimp, is challenging due to the similarity of allergenic proteins from other invertebrates. Despite the clinical importance of immunological cross-reactivity among shellfish species and between allergenic invertebrates such as dust mites, the underlying molecular basis is not well understood. Here we mine the complete transcriptome of five frequently consumed shrimp species to identify and compare allergens with all known allergen sources. The transcriptomes were assembled de novo, using Trinity, from raw RNA-Seq data of the whiteleg shrimp (Litopenaeus vannamei), black tiger shrimp (Penaeus monodon), banana shrimp (Fenneropenaeus merguiensis), king shrimp (Melicertus latisulcatus), and endeavour shrimp (Metapenaeus endeavouri). BLAST searching using the two major allergen databases, WHO/IUIS Allergen Nomenclature and AllergenOnline, successfully identified all seven known crustacean allergens. The analyses revealed up to 39 unreported allergens in the different shrimp species, including heat shock protein (HSP), alpha-tubulin, chymotrypsin, cyclophilin, beta-enolase, aldolase A, and glyceraldehyde-3-phosphate dehydrogenase (G3PD). Multiple sequence alignment (Clustal Omega) demonstrated high homology with allergens from other invertebrates including mites and cockroaches. This first transcriptomic analyses of allergens in a major food source provides a valuable resource for investigating shellfish allergens, comparing invertebrate allergens and future development of improved diagnostics for food allergy.

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Section: Discussionmentioning

confidence: 99%

Novel Allergen Discovery through Comprehensive De Novo Transcriptomic Analyses of Five Shrimp Species

Karnaneedi

Huerlimann

Johnston

et al. 2020

IJMS

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“…A study from the Swedish Prospective Birth Cohort showed that fish consumption during infancy was associated with the development of allergic disease by the age of 12 years and that regular fish consumption during infancy reduced the risk of allergic disease up to the age of 12 years (45) . Another study of a primary population of patients over 14 years of age with AD showed that allergy to fish in AD patients was associated with persistent eczematous skin lesions (46) . However, our study showed no causal relationship between fish intake (neither oily nor non-oily) and AD.…”

Section: Discussionmentioning

confidence: 99%

Dietary factors and the risk of atopic dermatitis: a Mendelian randomisation study

Che,

Yuan,

Wang

et al. 2024

Br J Nutr

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Previous studies have revealed an association between dietary factors and atopic dermatitis (AD). To explore whether there was a causal relationship between diet and AD, we performed Mendelian randomization (MR) analysis. The dataset of 21 dietary factors was obtained from UK Biobank. The dataset for AD was obtained from the publicly available FinnGen consortium. The main research method was the inverse-variance weighting method, which was supplemented by MR‒Egger, weighted median and weighted mode. In addition, sensitivity analysis was performed to ensure the accuracy of the results. The study revealed that beef intake (OR=0.351; 95% CI:0.145-0.847; p=0.020) and white bread intake (OR=0.141; 95% CI:0.030-0.656; p=0.012) may be protective factors against AD. There were no causal relationships between AD and any other dietary intake factors. Sensitivity analysis showed that our results were reliable, and no heterogeneity or pleiotropy was found. Therefore, we believe that beef intake may be associated with a reduced risk of AD. Although white bread was significant in the IVW analysis, there was large uncertainty in the results given the wide 95% CI. Other factors were not associated with AD in this study.

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Food allergy to shrimps and fish in patients suffering from atopic dermatitis, the results of ISAC Multiplex examination

Čelakovská

Bukač

Vaňková

et al. 2020

Food and Agricultural Immunology

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The aim of this study is the evaluation of the occurrence of fish/ shrimp allergy in atopic dermatitis patients. The occurrence of fish/shrimp allergy was confirmed in the challenge test or according to the history; the sensitisation to molecular components with ISAC Multiplex testing was analysed. Altogether 100 atopic dermatitis patients were examined. The food allergy to fish was confirmed in 13 patients (13%), while shrimp allergy occurred in 6 patients (6%).In patients with allergy to fish, the significantly higher occurrence of sensitisation to Asp f 1, Asp f 6, Alt a 6, Der f 1, Der f 2, Der p 1, Der p 2, Lep d 2 and Blo t 5 was confirmed. In patients with food allergy to shrimps, the significantly higher occurence of sensitisation to Asp f 6, Alt a 6, Cla h 8, Bla g 1 and Bla g 5 was confirmed also.

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Food hypersensitivity reactions to seafish in atopic dermatitis patients older than 14 year of age – The evaluation of association with other allergic diseases and parameters

Cited by 5 publications

References 44 publications

Novel Allergen Discovery through Comprehensive De Novo Transcriptomic Analyses of Five Shrimp Species

Novel Allergen Discovery through Comprehensive De Novo Transcriptomic Analyses of Five Shrimp Species

Dietary factors and the risk of atopic dermatitis: a Mendelian randomisation study

Food allergy to shrimps and fish in patients suffering from atopic dermatitis, the results of ISAC Multiplex examination

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