“…However, reperfusion can further damage the ischemic myocardium, referred to as myocardial ischemia/reperfusion injury (MIRI) ( 5 ), which can affect the prognosis of patients. Currently, the main clinical treatment for myocardial ischemia is percutaneous artery intervention (PCI), however, this treatment only provides short-term relief and also leads to myocardial re-damage ( 6 ). Other current treatments, such as calcium channel blockers or hypoxia preconditioning, are used for MIRI but are not very effective, as multiple factors are involved in the pathophysiological process of MIRI ( 7 , 8 ), there is an urgent requirement to find more therapeutic solutions for MIRI.…”