Force measurement goes to femto-Newton sensitivity of single microscopic particle

Zhang, Xiaohe; Gu, Bing; Qiu, Cheng‐Wei

doi:10.1038/s41377-021-00684-6

Cited by 11 publications

(4 citation statements)

References 13 publications

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“…13(c)] [177] . Suspended particles could be trapped in the stagnation zone with balanced counterflows [178,179] . Moreover, by translating the laser spot, the trapping sites would evolve accordingly, which always locate several micrometers away from the plasmonic hot region, as exhibited in Fig.…”

Section: Opto-thermoelectrohydrodynamic Tweezersmentioning

confidence: 99%

Optical manipulation: from fluid to solid domains

et al. 2023

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.Light carries energy and momentum, laying the physical foundation of optical manipulation that has facilitated advances in myriad scientific disciplines, ranging from biochemistry and robotics to quantum physics. Utilizing the momentum of light, optical tweezers have exemplified elegant light–matter interactions in which mechanical and optical momenta can be interchanged, whose effects are the most pronounced on micro and nano objects in fluid suspensions. In solid domains, the same momentum transfer becomes futile in the face of dramatically increased adhesion force. Effective implementation of optical manipulation should thereupon switch to the “energy” channel by involving auxiliary physical fields, which also coincides with the irresistible trend of enriching actuation mechanisms beyond sole reliance on light-momentum-based optical force. From this perspective, this review covers the developments of optical manipulation in schemes of both momentum and energy transfer, and we have correspondingly selected representative techniques to present. Theoretical analyses are provided at the beginning of this review followed by experimental embodiments, with special emphasis on the contrast between mechanisms and the practical realization of optical manipulation in fluid and solid domains.

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Section: Opto-thermoelectrohydrodynamic Tweezersmentioning

confidence: 99%

Optical manipulation: from fluid to solid domains

et al. 2023

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“…Optical tweezing, also known as a single-beam gradient force trap, has the sensitivity of trapping a single molecule or a single nanoparticle and is frequently used in biomedical applications [ 17 ]. Depending on the refractive index of particles and surrounding medium, a laser beam creates attractive or repulsive forces [ 135 ], which can manipulate even dielectric and absorbing particles at the focal point, Figure 11 , which is also known as beam waist [ 14 , 19 , 136 ].…”

Section: Microfluidicsmentioning

confidence: 99%

Biomedical Applications of Microfluidic Devices: A Review

et al. 2022

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Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. This review provides a comprehensive overview of the significant advances that have been made in the development of microfluidics devices. We will discuss the function of microfluidic devices as micromixers or as sorters of cells and substances (e.g., microfiltration, flow or displacement, and trapping). Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). An anticipated development in the field includes the optimization of techniques for the fabrication of microfluidic devices using biocompatible materials. These developments will increase biomedical versatility, reduce diagnostic costs, and accelerate diagnosis time of microfluidics technology.

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“…There are also a variety of other technologies which have gradually been developed for contact force measurement. For example, Zhang et al ( 19 ) used an optically controlled hydrodynamic manipulation method for measuring the weak force of a single microscopic particle. However, the accuracy of this technology is greatly affected by local electric and magnetic fields.…”

Section: Introductionmentioning

confidence: 99%

A nanonewton force sensor using a U-shape tapered microfiber interferometer

Chen,

Liu,

Markwell

et al. 2024

Sci. Adv.

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Nanomechanical measurements, especially the detection of weak contact forces, play a vital role in many fields, such as material science, micromanipulation, and mechanobiology. However, it remains a challenging task to realize the measurement of ultraweak force levels as low as nanonewtons with a simple sensing configuration. In this work, an ultrasensitive all-fiber nanonewton force sensor structure based on a single-mode–tapered U-shape multimode–single-mode fiber probe is proposed and experimentally demonstrated with a limit of detection of ~5.4 nanonewtons. The use of the sensor is demonstrated by force measurement on a human hair sample to determine the spring constant of the hair. The results agree well with measurements using an atomic force microscope for the spring constant of the hair. Compared with other force sensors based on optical fiber in the literature, the proposed all-fiber force sensor provides a substantial advancement in the minimum detectable force possible, with the advantages of a simple configuration, ease of fabrication, and low cost.

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Force measurement goes to femto-Newton sensitivity of single microscopic particle

Cited by 11 publications

References 13 publications

Optical manipulation: from fluid to solid domains

Optical manipulation: from fluid to solid domains

Biomedical Applications of Microfluidic Devices: A Review

A nanonewton force sensor using a U-shape tapered microfiber interferometer

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