Formation and characterization of natural polysaccharide hollow nanocapsules via template layer-by-layer self-assembly

Liu, Yuxi; Yang, Jing; Zhao, Ziqi; Li, Junjie; Zhang, Rui; Yao, Fanglian

doi:10.1016/j.jcis.2012.04.058

Cited by 52 publications

(31 citation statements)

References 35 publications

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“…Polystyrene nanoparticles templates have a negative charge due to the presence of sulphate ester groups (Sun et al, 2005), so the initial step of polysaccharide multilayer construction consisted in the adsorption of the positively charged chitosan solution.potential alternated between positive (more than +30 mV) and negative (less than −30 mV) values after deposition of chitosan and fucoidan, respectively, indicating the successfully deposition of these polysaccharides on the polystyrene nanoparticles up to 10 layers. Similar results were obtained by other authors for chitosan and alginate assembled on polystyrene (Ye et al, 2005) and SiO 2 -NH 2 templates (Liu et al, 2012).…”

Section: -Potential Measurementssupporting

confidence: 91%

Chitosan/fucoidan multilayer nanocapsules as a vehicle for controlled release of bioactive compounds

Pinheiro

Bourbon

Cerqueira

et al. 2015

Carbohydrate Polymers

175

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Hollow multilayer nanocapsules were successfully prepared through layer-by-layer assembly of two bioactive polysaccharides, chitosan and fucoidan. The stepwise adsorption of 10 chitosan/fucoidan layers and the consequent formation of a multilayer film on polystyrene nanoparticles (used as templates) were followed through ζ-potential measurement and the removal of the polystyrene core was confirmed by FTIR analysis. The chitosan/fucoidan nanocapsules morphology and size were evaluated by SEM and TEM, which showed that after the core removal, the nanocapsules maintained their spherical shape and a decrease of size occurred. A cationic bioactive compound, poly-L-lysine (PLL), was chosen to evaluate the loading and release behaviour of the nanocapsules. The chitosan/fucoidan nanocapsules showed a good capacity for the encapsulation and loading of PLL, which shows to be influenced by the initial PLL concentration and the method of encapsulation used. The results of fitting the linear superimposition model to the experimental data of PLL release suggest an anomalous behaviour, with one main polymer relaxation. The PLL release was found to be pH-dependent: at pH 2 relaxation is the governing phenomenon and at pH 7 Fick's diffusion is the main mechanism of PLL release. Chitosan/fucoidan nanocapsules is a promising delivery system for water soluble bioactive compounds, such as PLL, showing a great potential of application in food and pharmaceutical industries.

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Section: -Potential Measurementssupporting

confidence: 91%

Chitosan/fucoidan multilayer nanocapsules as a vehicle for controlled release of bioactive compounds

Pinheiro

Bourbon

Cerqueira

et al. 2015

Carbohydrate Polymers

175

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“…Electrostatic LbL self-assembly of carrageenan, an anionic sulfated polysaccharide, with chitosan was reported by Liu et al [17]. The LbL self-assembly onto silicon dioxide nanospheres, and the subsequent removal of the template silica particles, produced hollow nanocapsules of alternating polymer layers.…”

Section: Ph-responsive Carrageenan-chitosan Hollow Nanoparticlesmentioning

confidence: 88%

“…Self-assembly of polysaccharide nanoparticles is also possible through electrostatic interaction of ionic polysaccharides of opposite charges [17]. Ionic complexes are attractive for their simplicity and because their selfassembly is responsive to pH and ionic strength.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

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Self-assembling polysaccharide nanostructures have moved to the forefront of many fields due to their wide range of functional properties and unique advantages, including biocompatability and stimulus responsiveness. In particular, the field of controlled release, which involves influencing the location, concentration, and efficacy of active pharmaceutical ingredients (APIs), diagnostics, nutrients, or other bioactive compounds, has benefited from polysaccharide biomaterials. Nanostructure formation, stimulus responsiveness, and controlledrelease performance can be engineered through facile chemical functionalization and noncovalent intermolecular interactions. This review discusses polysaccharide nanoparticles, designed for targeted and time-controlled delivery of emerging APIs, with improved in vivo retention, stability, solubility, and permeability characteristics. Topics covered include nanoparticles of cyclodextrin and cyclodextrin-containing polymers, hydrophobically modified polysaccharides, polysaccharide nanoparticles that respond to pH, temperature, or light stimulus, polysaccharide prodrug complexes, polysaccharide complexes with lipids and proteins, and other polysaccharide polyelectrolyte complexes.

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“…Electrostatic self‐assembly is a traditional and effective method for modifying the surface of templates, and to further fabricate CPNCs after removal of the templates. Yao and co‐workers generated multilayer CPNCs (with D av of ca 150 nm as measured using TEM) via LbL electrostatic self‐assembly of natural polysaccharides carrageenan as polyanion and chitosan as polycation on amine‐modified silica NPs, followed by glutaraldehyde crosslinking and removal of silica core (with D av of ca 100 nm measured using TEM) . Wu and co‐workers also prepared biodegradable CPNCs (with D av of ca 200 nm measured using TEM) via LbL assembly of tertiary amine‐ and hydrazide‐grafted polyaspartamide and carboxyl‐ and aldehyde‐grafted polyaspartamide on silica spheres, followed by hydrazone crosslinking and removal of silica core (with D av of ca 150 nm measured using TEM) .…”

Section: Cavitation Of Scnssmentioning

confidence: 99%

Crosslinked polymer nanocapsules

et al. 2016

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Formation and characterization of natural polysaccharide hollow nanocapsules via template layer-by-layer self-assembly

Cited by 52 publications

References 35 publications

Chitosan/fucoidan multilayer nanocapsules as a vehicle for controlled release of bioactive compounds

Chitosan/fucoidan multilayer nanocapsules as a vehicle for controlled release of bioactive compounds

Self-assembled polysaccharide nanostructures for controlled-release applications

Crosslinked polymer nanocapsules

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