Formation of Follicular Cysts in Cattle and Therapeutic Effects of Controlled Internal Drug Release

Todoroki, Junichi; Kaneko, Hiroyuki

doi:10.1262/jrd.17081

Cited by 19 publications

(17 citation statements)

References 33 publications

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“…Similar to studies in Dutch [21], Spanish [22], and German [23] dairy herds, cows producing more milk had a greater incidence of cystic ovaries, presumably through alterations to the hypothalamic-pituitary-gonadal axis, particularly failure of the preovulatory LH surge [24,25]. Cystic ovaries have previously been reported to be positively genetically correlated with 305-day milk yield in both Dutch [26] and Canadian Holstein [27] cows.…”

Section: Milk Production and Detailed Reproductive Traitssupporting

confidence: 62%

Ovarian structures and uterine environment are associated with phenotypic and genetic merit for performance in lactating dairy cows

et al. 2014

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Section: Milk Production and Detailed Reproductive Traitssupporting

confidence: 62%

Ovarian structures and uterine environment are associated with phenotypic and genetic merit for performance in lactating dairy cows

et al. 2014

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“…Development of a suitable animal model critically depends on the PCOS-related disorder to be investigated (Szukiewicz & Uilenbroek 1998). Although the model for prenatal exposure of androgens is hypothetical in cattle, some clinical conditions present in PCOS have been observed in cows, including polycystic ovaries, anovulation (Todoroki & Kaneko 2006) and hyperinsulinaemia (Adamiak et al 2005).…”

Section: Igf1 In Superovulated Bovine Embryo Donorsmentioning

confidence: 99%

The role of IGF1 in the in vivo production of bovine embryos from superovulated donors

Velazquez

Zaraza²,

Oropeza³

et al. 2009

Reproduction

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IGF1 plays an important role in bovine follicular growth, acquisition of oocyte competence and embryo viability. Current data also indicate a critical role for IGF1 in both the ovarian response and the embryo yield following the superovulatory treatments. IGF1 can have either positive or negative effects on embryo viability which is related to the concentration of IGF1 induced by superovulation treatment. These effects impact either on oocyte competence or directly on the embryo. Concentrations in the physiological range appear to result in the production of higher quality embryos, mainly due to the mitogenic and the anti-apoptotic activities of IGF1. However, high superovulatory responses are associated with decreased embryo viability and a concomitant increase in apoptosis. Studies in mice suggest that this increase in apoptosis is related to the downregulation of the IGF1 receptor in the embryo associated with high IGF1 concentrations. Strategies capable of controlling the IGF1 concentrations could be one approach to improve superovulation responses. A range of possible approaches for research within the IGF system in gonadotrophin-stimulated cattle is discussed in this review, including the possible use of superovulated female cattle as an alternative animal experimental model for research on reproductive disorders in humans associated with abnormal IGF1 concentrations.

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“…It is suggested that the lack ofan luteinizing hormone (LH) surge is an important physiological change in cystic cows (Todoroki and Kaneko 2006). Therefore, injection of gonadotropinreleasing hormone agonists or LH-like hormones (e.g.…”

Section: Introductionmentioning

confidence: 99%

Alternative Treatment of Ovarian Cysts with Tribulus terrestris Extract: A Rat Model

Dehghan

Esfandiari

Bigdeli

2011

Reprod Domestic Animals

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Tribulus terrestris has long been used in traditional medicine to treat impotency and improve sexual functions in man. The aim of this study was to evaluate the efficiency of T. terrestris extract in the treatment of polycystic ovary (PCO) in Wistar rat. Estradiol valerate was injected to 15 mature Wistar rats to induce PCO. Rats were randomly divided into three groups (control, low-dose and high-dose groups) of five each and received 0, 5 and 10 mg of T. terrestris extract, respectively.Treatments began on days 50 and 61 after estradiol injection; at the same time, vaginal smear was prepared. The ovaries were removed on day 62, and histological sections were prepared accordingly. The number and diameter of corpora lutea, thickness of the theca interna layer and the number of all follicles were evaluated in both ovaries. In comparison with the control group, the number of corpora lutea and primary and secondary follicles significantly increased following T. terrestris treatment; however, the number of ovarian cysts significantly decreased. It can be concluded that T. terrestris have a luteinizing effect on ovarian cysts, which may relate to its gonadotropin-like activity; also, a high dose of the extract can efficiently remove ovarian cysts and resume ovarian activity.

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Formation of Follicular Cysts in Cattle and Therapeutic Effects of Controlled Internal Drug Release

Cited by 19 publications

References 33 publications

Ovarian structures and uterine environment are associated with phenotypic and genetic merit for performance in lactating dairy cows

Ovarian structures and uterine environment are associated with phenotypic and genetic merit for performance in lactating dairy cows

The role of IGF1 in the in vivo production of bovine embryos from superovulated donors

Alternative Treatment of Ovarian Cysts with Tribulus terrestris Extract: A Rat Model

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