Formation of SARS-CoV-2 Specific Antibody after vaccination

Rotty, Ivonne Elisabeth; Kristanto, Erwin; Sekeon, Sekplin A. S.; Ekawardani, Neni; Liwe, Henny Ruth

doi:10.35790/ecl.v10i1.37193

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…There was an increase in antibodies formed at the first examination compared to the second examination, from a median of 418.3 AU/mL to 457.7 AU/ml. This increase was also observed at the third examination, to 457.7 AU/ml, although there was a decrease in the mean from 525.5 AU/ml to 457.7 AU/ml [18].…”

Section: Discussionmentioning

confidence: 57%

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Effect of Vaccination Status on SARS-CoV-2 Antibody Levels in Gowa Regency Community, Indonesia

Mulyani Ilmy,

Ridwan,

Zulkifli

et al. 2023

ijsmr

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Background: COVID-19 is a disease caused by infection with SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2). One of the body's immune responses to infection is to produce antibodies. Acute SARS-CoV-2 infection initiates cellular and humoral immune responses. The humoral immune response specifically generates antibodies against virus-specific antigens. Several factors influence the immune response, one of which is vaccination status. Therefore, this study aimed to determine and analyze the effect of vaccination status on SARS-CoV-2 antibody levels. Methods: An analytical observational study with a cross-sectional design involving 815 samples was conducted. The proportional random sampling technique was employed based on data obtained from the Seroepidemiology Survey. Data analysis was conducted using the STATA version 14.0 program with the Independent T-Test, Mann Whitney test, Kruskal Wallis test, and Multiple logistic regression. Results: The results showed that there was a significant relationship between the determinant variables of SARS-CoV-2 antibody levels based on gender (p=0.012), vaccination status (p=0.000), and COVID-19 infection history (p=0.000). Furthermore, the multivariate analysis indicated that vaccination status was the variable most associated with SARS-CoV-2 antibody levels (p = 0.010). The OR value = 0.16 < 1 and 95%CI (0.04-0.65) which did not contain a value of 1 suggested vaccination status to be a significant protective factor associated with SARS-CoV-2 antibody levels, with a probability value of 94.1%. Conclusion: The most influential variable on SARS-CoV-2 antibody levels in the Gowa Regency was vaccination status. Moreover, none of the variables measured were identified as confounding factors or showed interaction effects.

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Section: Discussionmentioning

confidence: 57%

“…A previous study by (Rotty et al, 2022) generally showed an increase in SARS-CoV-2 specific antibody titers (IgG) in vaccinated subjects. There was an increase in antibodies formed at the first examination compared to the second examination, from a median of 418.3 AU/mL to 457.7 AU/ml.…”

Section: Discussionmentioning

confidence: 97%

Effect of Vaccination Status on SARS-CoV-2 Antibody Levels in Gowa Regency Community, Indonesia

Mulyani Ilmy,

Ridwan,

Zulkifli

et al. 2023

ijsmr

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“…The response to the SARS-COV-2 pandemic that is considered the most effective to date is vaccinations equipped with the implementation of health protocols. Understanding the effectiveness of vaccination is currently very important, both to design a better response to SARS-CoV-2, and to provide education to potential vaccination participants (Rotty et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Antibody Levels Of Health Personnel Post-Booster Vaccination Phase-III

Fajri

Massi

2022

JurKebMal

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ABSTRACK Background: Health workers are one of the groups most at risk of being infected with Covid-19 due to their intense interactions with patients. Therefore, it is necessary to make efforts to increase the endurance of the pandemic by administering vaccines.Purpose: This study aims to determine the effectiveness of giving phase III booster vaccinations for health workers against increasing Covid-19 antibody titers.Methode: This study belongs to the type of descriptive quantitative research, the sampling technique is carried out using the slovin formula.Results: The results showed that constantly (100%), giving booster vaccinations to health workers can increase the effectiveness of the Covid-19 vaccine that has previously been given and is able to strengthen the antibody that has been awakened. Conclusion: The administration of the phase III booster vaccine can increase the titer of the Covid-19 antibody so that the risk of transmission of the corona virus can be suppressed.Suggestion: Other puskesmas can carry out phase-III booster vaccinations for health workers as a whole

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Spike-Receptor Binding Domain (SRBD) Antibodies Secretion in COVID-19 Survivors and Non-Survivors Post-Pre-Endemic Vaccination

Museyaroh

Woelansari

Kriharyani

2022

FMI

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Highlights The research this for determine the presence of immune response post-vaccine The results of this study indicate that there are differences in immune responses, in survivors patients have higher SRBD antibody levels than non-survivors Abstract : The development of a vaccine for SARS-COV-2 began in mid-2020 with the aim of stimulating an individual's immune response against SARS-CoV-2 infection. The purpose of this study was to determine the levels of post-vaccine SRBD antibody secreted in COVID-19 survivors and non-survivors. Antibodies are considered to play a more important role in evaluating immunity because antibody tests may provide information about a person's immune status against SARS-CoV-2. The study was conducted at Husada Utama Hospital, Surabaya, Indonesia, in April – May 2021. The samples were taken prospectively with a total sample of 60 patients, consisting of 40 non-survivors and 20 survivors of COVID-19 who had received Sinovac vaccine doses 1 and 2. Examination of Sars-CoV-2 SRBD antibody was conducted by using CL series of Mindray device by means of CLIA method. The average level of antibody was assessed in each sample group and the results were subjected to the Mann Whitney test. The mean SRBD antibody level in female patients was 428.24 ± 271.25, while in male patients it was 310.40 ± 113.71 U/mL. The results of the Mann Whitney test revealed a P-Value of 0.09 > 0.05, indicating no difference in post-vaccine SRBD antibody levels between females and males, but there were differences in SRBD antibody levels in COVID-19 survivors and non-survivors with a P-Value of <, i.e. 0.00 < 0.05 There was no difference in post-vaccine SRBD antibody levels between females and males in COVID-19 survivors and non-survivors, but there were differences in post-vaccine antibody levels between COVID-19 survivors and non-survivors.

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Formation of SARS-CoV-2 Specific Antibody after vaccination

Cited by 3 publications

References 12 publications

Effect of Vaccination Status on SARS-CoV-2 Antibody Levels in Gowa Regency Community, Indonesia

Effect of Vaccination Status on SARS-CoV-2 Antibody Levels in Gowa Regency Community, Indonesia

Antibody Levels Of Health Personnel Post-Booster Vaccination Phase-III

Spike-Receptor Binding Domain (SRBD) Antibodies Secretion in COVID-19 Survivors and Non-Survivors Post-Pre-Endemic Vaccination

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