Formin homology domains of Daam1 bind to Fascin and collaboratively promote pseudopodia formation and cell migration in breast cancer

Hao, Lijun; Liu, Yan; Yu, Xiaoman; Yue-rong, Zhu; Zhu, Yichao

doi:10.1111/cpr.12994

Cited by 17 publications

(8 citation statements)

References 40 publications

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“…Given that formins catalyze the formation of polymers of actin, it is not surprising that they play an important role in cancer cell migration. Examples of this function are DIAPH1-3 and DAAM1 in breast cancer [243,247], DIAPH1 in glioma [230], FMNL1 in nasopharyngeal carcinoma [277], FMNL2 in colorectal cancer [263], and FHOD1 in oral squamous carcinoma [280].…”

Section: The Role Of Formins In Cancermentioning

confidence: 99%

Formins in Human Disease

Labat-de-Hoz

Alonso

2021

Cells

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Almost 25 years have passed since a mutation of a formin gene, DIAPH1, was identified as being responsible for a human inherited disorder: a form of sensorineural hearing loss. Since then, our knowledge of the links between formins and disease has deepened considerably. Mutations of DIAPH1 and six other formin genes (DAAM2, DIAPH2, DIAPH3, FMN2, INF2 and FHOD3) have been identified as the genetic cause of a variety of inherited human disorders, including intellectual disability, renal disease, peripheral neuropathy, thrombocytopenia, primary ovarian insufficiency, hearing loss and cardiomyopathy. In addition, alterations in formin genes have been associated with a variety of pathological conditions, including developmental defects affecting the heart, nervous system and kidney, aging-related diseases, and cancer. This review summarizes the most recent discoveries about the involvement of formin alterations in monogenic disorders and other human pathological conditions, especially cancer, with which they have been associated. In vitro results and experiments in modified animal models are discussed. Finally, we outline the directions for future research in this field.

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Section: The Role Of Formins In Cancermentioning

confidence: 99%

Formins in Human Disease

Labat-de-Hoz

Alonso

2021

Cells

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“…Given that fascin is one of the main protein responsible for the rigid bundling of actin filaments and plays an important role in cytoskeleton remodeling 18 , 58 , 59 , we performed immunofluorescence assay to examine the subcellular localization of fascin in CaSki cells in the presence or absence of LA treatment. The results showed that the majority of fascin was induced to translocate from the nuclear to cytoplasmic compartment, and localized at the protrusion structure after LA treatment (Figure 4 A).…”

Section: Resultsmentioning

confidence: 99%

Lactate-mediated Fascin protrusions promote cell adhesion and migration in cervical cancer

Han¹,

Du²,

Rothenberg³

et al. 2023

Theranostics

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“…Additionally, in recent years, an important role for Wnt/PCP in cancer is being highlighted, since a strong correlation has been demonstrated between the up-regulation of PCP components, mainly RhoA, and the poor patient outcome in a variety of different cancer types [ 40 , 41 , 42 , 43 , 44 , 45 ]. Moreover, the over-expression of DAAM1 itself has been associated with the progression and invasiveness of several neoplasia, including breast [ 46 , 47 , 48 ] and prostate [ 49 ] cancers. Thus, considering this last point, and the fact that this is the first study indicating the correlation between the upregulated DAAM1 protein level and CS, it may be assumed that the involvement of this formin in the cellular events leading to neoplastic transformation.…”

Section: Resultsmentioning

confidence: 99%

Preliminary Investigation on the Involvement of Cytoskeleton-Related Proteins, DAAM1 and PREP, in Human Testicular Disorders

Venditti

Arcaniolo

Sio

et al. 2021

IJMS

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Herein, for the first time, the potential relationships between the cytoskeleton-associated proteins DAAM1 and PREP with different testicular disorders, such as classic seminoma (CS), Leydig cell tumor (LCT), and Sertoli cell-only syndrome (SOS), were evaluated. Six CS, two LCT, and two SOS tissue samples were obtained during inguinal exploration in patients with a suspect testis tumor based on clinical examination and ultrasonography. DAAM1 and PREP protein levels and immunofluorescent localization were analyzed. An increased DAAM1 protein level in CS and SOS as compared to non-pathological (NP) tissue was observed, while LCT showed no significant differences. Conversely, PREP protein level increased in LCT, while it decreased in CS and SOS compared to NP tissue. These results were strongly supported by the immunofluorescence staining, revealing an altered localization and signal intensity of DAAM1 and PREP in the analyzed samples, highlighting a perturbed cytoarchitecture. Interestingly, in LCT spermatogonia, a specific DAAM1 nuclear localization was found, probably due to an enhanced testosterone production, as confirmed by the increased protein levels of steroidogenic enzymes. Finally, although further studies are needed to verify the involvement of other formins and microtubule-associated proteins, this report raised the opportunity to indicate DAAM1 and PREP as new potential markers, supporting the cytoskeleton dynamics changes occurring during normal and/or pathological cell differentiation.

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Formin homology domains of Daam1 bind to Fascin and collaboratively promote pseudopodia formation and cell migration in breast cancer

Cited by 17 publications

References 40 publications

Formins in Human Disease

Formins in Human Disease

Lactate-mediated Fascin protrusions promote cell adhesion and migration in cervical cancer

Preliminary Investigation on the Involvement of Cytoskeleton-Related Proteins, DAAM1 and PREP, in Human Testicular Disorders

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