Formula Feeding as a Risk Factor for Attention-Deficit/Hyperactivity Disorder: Is Bisphenol A Exposure a Smoking Gun?

Adesman, Andrew; Soled, Derek; Rosen, Lisa

doi:10.1097/dbp.0000000000000468

Cited by 20 publications

(13 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results suggest a role of the gut microbiota in brain function and behavior and support communication between the gut and the brain (microbiota-gut-brain axis) [12,13]. Of note, many environmental risk factors of ADHD development, such as cesarean delivery [14], formula feeding [15], antibiotic use [16], and diet style [17] are also associated with gut bacterial compositions.…”

Section: Introductionmentioning

confidence: 74%

Gut metagenomics discriminates unique microbial signatures in diverse symptomatic profiles with attention-deficit/hyperactivity disorder

Sun

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a highly heterogeneous psychiatric disorder that can be divided into inattentive (I-ADHD), hyperactive-impulsive (HI-ADHD), and combined (C-ADHD) subtypes. Different early life events and environmental factors correlated with the gut microbiota community have been implicated in the development of ADHD. However, whether different ADHD symptomatic presentations are associated with distinct microbiota composition and function still unknown. Therefore, we carried out metagenomic analysis from 207 subjects to characterize the gut microbial profiles in ADHD and subgroup patients.ResultsThe current study revealed that the gut microbiota composition (beta diversity) can be effectively distinguished between C-ADHD patients and HCs, but not I-ADHD patients and HCs, nor general ADHD patients and HCs. Features include underrepresentation of 8 species belonging to the genus Bacteroides and enrichment of 5 species of Bifidobacterium and Prevotella in general ADHD patients (all p < 0.05). Eight of the above species became progressively reduced (ovatus, thetaiotaomicron, intestinalis, cellulosilyticus, and fluxus belonging to the genus Bacteroides) or enriched (Prevotella_copri, Prevotella_buccae and Bifidobacterium_breve) from healthy controls (HCs) to I-ADHD and C-ADHD patients. Predicted metabolic functions from these distinguished gut microbial markers described a certain compensatory host metabolism in ADHD and subgroup patients. Particularly, pyridoxal 5'-phosphate (a dominant vitamin B6 active type) biosynthesis pathways were significantly reduced in C-ADHD patients, because serum vitamin B6 deficiency in ADHD patients was found previously. Of note, we identified diverse virulence factor and antibiotic resistance from the gut microbiota of ADHD patients. The abundance of antibiotic resistance ontology ANT(9)-Ia positively correlated with the abundance of Prevotella_amnii, which was enriched in ADHD patients. Moreover, species-based bacterial markers were used to construct classifiers and achieved a higher AUC of 0.87 in C-ADHD vs. HC than that in ADHD vs. HC (AUC = 0.84).ConclusionsThese findings uncover alterations in microbial composition in subgroup patients and provide potential biomarkers for diagnosis different symptomatic presentations for ADHD.Trial registration: ClinicalTrials.gov, NCT03447223. Registered 27 February 2018, https://clinicaltrials.gov/ct2/show/NCT03447223?term=03447223&draw=2&rank=1

show abstract

Section: Introductionmentioning

confidence: 74%

Gut metagenomics discriminates unique microbial signatures in diverse symptomatic profiles with attention-deficit/hyperactivity disorder

Sun

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…This was in the same line with Casas et al (2013), who reported that the detected urinary BPA was due to dietary exposure, as the diet was the primary source of BPA exposure (Morgan et al, 2011). Adesman et al (2017) found a significant association between formulafeeding and ADHD, as non-breast-fed (formula fed) children had 5 fold increased risk of ADHD. However, the same association in 2011not found; 2 to 3 years after removal of BPA from infant formula cans and baby bottles.…”

Section: Discussionmentioning

confidence: 94%

“…An association was reported between BPA exposure, childhood behavior and cognitive development disorders (Harley et al, 2013;Hong et al, 2013;Evans et al, 2014;Roen et al, 2015;Adesman et al, 2017), as BPA had been detected as an organic developmental neurotoxic agent (Grandjean and Landrigan, 2014).…”

Section: Introductionmentioning

confidence: 99%

urinary bisphenol A concentration in children with Attention-deficit/hyperactivity disorder : a pilot study

Mohamed

ibraheem

aly

2020

The Egyptian Journal of Forensic Sciences and Applied Toxicolog

View full text Add to dashboard Cite

Background: Bisphenol A (BPA) is an industrial chemical associated with several health effects and exposure to BPA remains poorly characterized in the developing countries. In this pilot study, we evaluated BPA exposure, assessed some sources of exposure and its health effects among Egyptian children. Methods: Total BPA concentration was measured in two groups of spot urinary samples of ADHD (N = 24) and apparently healthy control (N = 24) children. Questionnaire data regarding food storage behaviors to assess potential sources of exposure was collected. Results: ADHD children exhibited higher urinary BPA concentrations; with median value of 24.5 µg/L. Reported consumption of canned food was a significant predictor of increasing concentrations of urinary BPA. Conclusion: The reported relatively high urinary BPA concentrations within Egyptian children with ADHD and the significant association between the canned food consumption and the increased urinary BPA concentration highlights the need to modify food and consumer product patterns to prevent potential adverse health outcomes in the future.

show abstract

“…One study found that formula-fed infants suffered more often of ADHD in 2007 in comparison to 2011/12. During the latter, the neurotoxic chemical Bisphenol A (BPA) was significantly reduced in formula cans and baby bottles in comparison to the former, suggesting that BPA might be the actual trigger of the correlation [170]. Table 3.…”

Section: Breastfeeding Vs Formula Feedingmentioning

confidence: 99%

The Potential Influence of the Microbiome on the Development and Progression of ADHD

Bull-Larsen¹,

Mohajeri²

2019

Preprint

View full text Add to dashboard Cite

The latest research cumulates staggering information about the correlation between the microbiota-gut-brain axis and neurodevelopmental disorders. This review aims to shed light on the potential influence of the microbiome on the development of the most prevalent neurodevelopmental disease, attention-deficit-hyperactive disorder (ADHD). As the etiology and pathophysiology of ADHD are still unclear, finding viable biomarkers and effective treatment still represent a challenge. Therefore, we focused on factors that have been associated with a higher risk of developing ADHD while simultaneously influencing the microbial composition. We reviewed the effect of a differing microbial composition on neurotransmitter concentrations important in the pathophysiology of ADHD. Additionally, we deduced factors that correlate with a high prevalence of ADHD while simultaneously affecting the gut microbiome such as emergency c-sections, and premature birth as the former leads to a decrease of the gut microbial diversity and the latter causes neuroprotective Lactobacillus levels to be reduced. Also, we assessed nutritional influences such as breastfeeding, ingestion of short-chain fatty acids (SCFAs) and polyunsaturated fatty acids (PUFAs) on the host's microbiome and development of ADHD. Finally, we discussed the potential significance of Bifidobacterium as a biomarker for ADHD, the importance of preventing premature birth as prophylaxis and nutrition as a prospective therapeutic measurement against ADHD.

show abstract

Formula Feeding as a Risk Factor for Attention-Deficit/Hyperactivity Disorder: Is Bisphenol A Exposure a Smoking Gun?

Cited by 20 publications

References 25 publications

Gut metagenomics discriminates unique microbial signatures in diverse symptomatic profiles with attention-deficit/hyperactivity disorder

Gut metagenomics discriminates unique microbial signatures in diverse symptomatic profiles with attention-deficit/hyperactivity disorder

urinary bisphenol A concentration in children with Attention-deficit/hyperactivity disorder : a pilot study

The Potential Influence of the Microbiome on the Development and Progression of ADHD

Contact Info

Product

Resources

About