Formulasi Dan Evaluasi Emulgel Itraconazol

Abstract

traconazole is a systemic antifungal triazole derivative that has a close relationship with ketoconazole. Itraconazole has greater antifungal activity but fewer side effects, with oral administration such as nausea, vomiting, dizziness, leg edema, and loss of libido. Itraconazole is practically insoluble in water. To overcome this problem, one step that can be done is to formulate itraconazole in a topical microemulsion dosage form with a particle size of 10-200 nm. The itraconazole microemulsion was then incompatible in an emulgel preparation which increased the ease and comfort of use. This Emulgel Sedian is made in 3 formulas. This study aims to identify and develop gel preparations containing itraconazole microemulsion as an antifungal. The results of the evaluation of the emulgel showed that the overall organoleptic observation test showed that it was in the form of an emulgel, and did not show any changes or phase separation during the 28 days storage time. The homogenous test shows that all preparation formulas are homogeneous and there are no coarse particles visually. The pH determination test of the preparation showed that the skin pH was 4.5 -6.5. Test the viscosity of F1, F2, F3 preparations using a Brookfield Viscometer with spindle no. 5 at a speed of 50 rpm produced a good viscosity of the dosage. The spreadability test showed semistiff type results in the 3-5cm range. whereas in the centrifugation test, the emulgel preparation was centrifuged at a speed of 5000 rpm for 20 minutes, showing the results that all formulas did not experience separation. This indicates that the itraconazole emulgel preparation meets the requirements as an emulgel preparation