No abstract

No abstract

traconazole is a systemic antifungal triazole derivative that has a close relationship with ketoconazole. Itraconazole has greater antifungal activity but fewer side effects, with oral administration such as nausea, vomiting, dizziness, leg edema, and loss of libido. Itraconazole is practically insoluble in water. To overcome this problem, one step that can be done is to formulate itraconazole in a topical microemulsion dosage form with a particle size of 10-200 nm. The itraconazole microemulsion was then incompatible in an emulgel preparation which increased the ease and comfort of use. This Emulgel Sedian is made in 3 formulas. This study aims to identify and develop gel preparations containing itraconazole microemulsion as an antifungal. The results of the evaluation of the emulgel showed that the overall organoleptic observation test showed that it was in the form of an emulgel, and did not show any changes or phase separation during the 28 days storage time. The homogenous test shows that all preparation formulas are homogeneous and there are no coarse particles visually. The pH determination test of the preparation showed that the skin pH was 4.5 -6.5. Test the viscosity of F1, F2, F3 preparations using a Brookfield Viscometer with spindle no. 5 at a speed of 50 rpm produced a good viscosity of the dosage. The spreadability test showed semistiff type results in the 3-5cm range. whereas in the centrifugation test, the emulgel preparation was centrifuged at a speed of 5000 rpm for 20 minutes, showing the results that all formulas did not experience separation. This indicates that the itraconazole emulgel preparation meets the requirements as an emulgel preparation

Paracetamol causes liver damage if consumed more than normal limits continuously. Liver damage is characterized by increased levels of the enzymes Serum Glutamic Pyruvic Transaminase (SGPT) and Serum Glutamic Oxaloacetic Transaminase (SGOT) in the blood. Antioxidants can prevent paracetamol-induced liver damage. Telang flower (Clitoria ternatea) is a plant that has the potential to prevent liver damage because it has high antioxidant activity. This study aimed to examine the hepatoprotective activity of ethanol extract of telang flower in rats induced by paracetamol. Rats were grouped into 6 groups consisting of normal control without paracetamol induction, negative control, positive control, test doses 1, 2, and 3 were given paracetamol as much as 150 mg/200 g BW on day 1 to day 7. After 1 hour, the positive control group was given curliv 37 mg/200 g BW, test doses 1, 2, and 3 were given ethanol extract of telang flower, respectively 123 mg/200 g BW, 247 mg/200 g BW, and 370 mg/200g BW on day 1 until the 7th day. On the 8th day, the rat's blood was taken and then measured SGPT and SGOT were by an enzymatic method using a photometer. Based on the results of statistical analysis, Telang flower ethanol extract doses 1, 2, 3, and positive control showed a significantly different decrease in SGPT and SGOT compared to negative control but only dose 2 (247 mg/200 g BW) showed hepatoprotective activity equivalent to positive control.

ABSTRAK Antioksidan merupakan suatu senyawa yang sangat penting dalam memelihara kesehatan. Salah satu bahan alam yang berkhasiat sebagai antioksidan adalah biji limus (Mangifera foetida L.) yang merupakan salah satu spesies mangga dari golongan anacardiaceae yang menyebar di wilayah Indonesia. Penelitian ini bertujuan untuk mengetahui fraksi yang memiliki aktivitas antioksidan yang paling baik pada kernel biji limus dengan metode Bioassay Guided Fractionation melalui reaksi penangkapan radikal bebas DPPH. Penyarian kernel biji buah limus dilakukukan menggunakan metode maserasi dengan pelarut etanol 96%. Ekstrak selanjutnya difraksinasi dengan pelarut n-heksana, etil asetat, metanol dan air. Aktivitas antioksidan masing-masing fraksi diukur menggunakan spekrofotometer UV-Visible. Hasil menunjukan bahwa fraksi etil asetat ekstrak etanol kernel biji limus memberikan potensi antioksidan yang paling baik yaitu dengan nilai ES50 sebesar 1,164±0.005 μg/mL (sangat kuat), melebih potensi vitamin C sebagai pembandingnya. Kata Kunci: Biji limus, Mangifera, Antioksidan, DPPH. ABSTRAK Antioxidants are very important compounds in maintaining health. One of the natural ingredients has efficacious as an antioxidant is Limus (Mangifera foetida L.) seeds which is one of the mango species from the Anacardiaceae group which spreads in the territory of Indonesia. This study aims to screen the fraction that has the high antioxidant potential of the Lotus seed kernel used Bioassay-Guided Fractionation method through scavenging reaction of DPPH as free radical. The extraction of the limus seeds was carried out using the maceration method with 96% ethanol. The extract was then fractionated with n-hexane, ethyl acetate, methanol, and water solvents. The antioxidant activity of each fraction was measured using a UV-Visible spectrophotometer. The results showed that the ethyl acetate fraction of the limus seed ethanol extract provided the high antioxidant potential with an ES50 value of 1.164 ± 0.005 μg / mL (very strong), exceeding the potential of vitamin C as a standard compound. Keywords: Limus seeds, Mangifera, Antioxidants, DPPH.