FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN KRIM EKSTRAK ETANOL DAUN MURBEI (Morus alba L.) MENGGUNAKAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazyl)

Pogaga, Eklesia; Yamlean, Paulina V. Y.; Lebang, Julianri Sari

doi:10.35799/pha.9.2020.30018

Cited by 10 publications

(13 citation statements)

References 2 publications

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“…DPPH merupakan penangkal radikal bebas yang baik dalam larutan metanol atau etanol dan memiliki warna ungu tua. 10 Selain itu perlu dilakukan uji iritasi pada sediaan krim untuk mengetahui keamanan krim ekstrak tersebut pada kulit manusia. Uji hedonik juga perlu dilakukan untuk mengetahui tingkat kesukaan responden terhadap sediaan krim ekstrak tersebut.…”

Section: Pendahuluanunclassified

Pengaruh Variasi Gliseril Monostearat pada Krim Ekstrak Kulit Buah Naga Merah Super (Hylocereus costaricensis) dan Uji Antioksidannya

Nugrahaeni

Yati²,

Sukmara³

2023

jki

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A Glyceryl monostearate can be used as an emulsifier because it can affect the increase in antioxidant activity. The study aims to determine the effect of fluctuations in the concentration of glyceryl monostearate (GMS) on the physical properties of cream preparations containing 70% ethanol extract from the skin of super red dragon fruit and their antioxidant activity. The research methods carried out experimentally include the manufacture of extracts from super red dragon fruit peel, phytochemical screening using thin layer chromatography, formulations using various concentrations of glyceryl monostearate 8%, 10%, 12% then the physical quality of the cream and antioxidant activity test using the DPPH method. The results of one-way ANOVA for pH, dispersion, adhesion, and viscosity tests showed a p-value of> 0.05, indicating that there was no significant difference. The IC50 results obtained with equations 1, 2, and 3 are 3.69 mg/L, respectively. 3.98mg/L; and 4.78mg/L. Formula 3 is the best formula and estimates the antioxidant activity of Vitamin C, which is a positive control, at a value of 5.83 mg/L. The results of the irritation test showed that none of the formulations caused irritation. The preference test results showed that the respondents liked all the formulas. The conclusion of this study is that increased fluctuations in the concentration of glyceryl monostearate did not affect the physical properties of super red dragon fruit skin extract cream, but did affect its antioxidant activity.

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Section: Pendahuluanunclassified

Pengaruh Variasi Gliseril Monostearat pada Krim Ekstrak Kulit Buah Naga Merah Super (Hylocereus costaricensis) dan Uji Antioksidannya

Nugrahaeni

Yati²,

Sukmara³

2023

jki

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“…Saat dioleskan di kulit juga tidak terdapat butiran kasar yang menggumpal. Sehingga dapat disimpulkan bahwa sediaan gel ekstrak buah Okra memiliki homogenitas sediaan yang memenuhi syarat dan stabil selama 14 penyimpanan pada suhu ruang (25°C) (Pogaga et al, 2020).…”

Section: Formulaunclassified

The Effect of Variations in HPMC and Carbopol Bases on The Physical Stability of Okra (Abelmoschus esculentus L.) Fruit Gel Formulations

Idrus,

Apriyanti,

Katadi

et al. 2023

B.J

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Okra fruit (Abelmoschus esculentus L.) is a vegetable that is often used as medicine. Okra fruit contains flavonoids which are antioxidants. Gel formulation with a concentration of 5%, and various combinations of HPMC and carbopol bases. This research aims to determine the physical stability of gel preparations and the effect of variations in the concentration of gelling ingredients in the preparations. The gel formulation consists of 4 formulas, namely F0, F1, F2, and F3. Physical stability tests include organoleptic tests (odor, color and texture), homogeneity, pH, spreadability, stickiness, viscosity and synergy. Tests were carried out for 14 days of storage, namely on days 1, 3, 5, 7, and 14 at room temperature (25℃). The observation results showed that in the organoleptic test there was no change in color, odor and texture in the gel preparation during 14 days of storage. The four gel formulas are homogeneous and there is no synergy. Variations in the combination of HPMC and carbopol bases affect the physical properties of the gel, including pH, viscosity, spreadability and adhesion. HPMC and Carbopol affect the pH of the preparation, the higher the Carbopol content and the lower the HPMC content, the more acidic it is. Carbopol and HPMC affect the values of spreadability, viscosity and adhesion because the higher the concentration of carbopol and HPMC produces a thick gel preparation so that the spreadability decreases, viscosity increases and adhesion also increases.

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“…The negative impact of free radicals can damage cells excessively, accelerating premature aging (Handayani et al, 2018). One way to overcome the negative impact of free radicals is to use antioxidant compounds (Pogaga et al, 2020). Antioxidants are commonly found in plants.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Testing of Antioxidant Activity Combination of Calendula Oil and Sweet Orange Oil With DPPH Method

Firmansyah,

Indriaty,

Karlina

et al. 2024

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Indonesia has many natural ingredients that can be used as primary ingredients for medicines with antioxidant effects. Calendula oil and sweet orange oil have the potential to be antioxidants. This study aimed to determine the stability of cream preparations based on stability test parameters and to determine antioxidant activity using the DPPH method. This study was conducted because the combination of calendula oil and sweet orange oil was tested for antioxidant activity and then formulated in cream dosage forms with ratio of 1:1, 1:2, and 2:1. Antioxidant activity tests were carried out using a combination of calendula oil and sweet orange oil and a cream preparation of a combination of calendula oil and sweet orange oil, which was tested for stability using the cycling test method. Based on the results of the study, the combination of calendula oil and sweet orange oil in a ratio of 1:1 and 1:2 had weak antioxidant activity, as can be seen from the IC50 value of 170.02 ppm, 150.43 ppm, whereas in a 2:1 ratio, it had moderate antioxidant activity because the IC50 value was 143.89 ppm. In the combination cream preparations of calendula oil and sweet orange oil, ratios of 1:1, 1:2, and 2:1 had weak antioxidant activity. It can be seen from the IC50 value of each preparation, which was 188.85 ppm, 170.01 ppm, and 189.61 ppm. Keywords: Calendula Oil, Sweet Orange Oil, Antioxidant, Cream, DPPH

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FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN KRIM EKSTRAK ETANOL DAUN MURBEI (Morus alba L.) MENGGUNAKAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazyl)

Cited by 10 publications

References 2 publications

Pengaruh Variasi Gliseril Monostearat pada Krim Ekstrak Kulit Buah Naga Merah Super (Hylocereus costaricensis) dan Uji Antioksidannya

Pengaruh Variasi Gliseril Monostearat pada Krim Ekstrak Kulit Buah Naga Merah Super (Hylocereus costaricensis) dan Uji Antioksidannya

The Effect of Variations in HPMC and Carbopol Bases on The Physical Stability of Okra (Abelmoschus esculentus L.) Fruit Gel Formulations

Formulation and Testing of Antioxidant Activity Combination of Calendula Oil and Sweet Orange Oil With DPPH Method

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