Formulasi Hand Sanitizer dari Ekstrak Biji Pangi  (Pangium edule Reinw)

Rohana, Rohana; Stevani, Hendra; Ratnasari, Dewi

doi:10.32382/mf.v15i2.1133

Cited by 5 publications

(9 citation statements)

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“…Viscosity test of chemical physics properties using Viscometer Rheosys tool with speed 50 rpm for jatropha sap and 2 rpm for preparation, conducted for 60 seconds and replicated 3 times [7].…”

Section: Viscosity Testmentioning

confidence: 99%

Formulation of Hand Sanitizer Gel Jatropha Sap (Jatropha curcas L) as Antiseptic

Siswati

Aryati

Narsa

2022

J. Trop. Pharm. Chem.

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Jatropha curcas (Jatropha curcas L) is a medicinal plant that is often used, especially its sap. Jatropha sap contains secondary metabolite compounds in the form of saponins, flavonoids, and tannins which have antibacterial activity. This study aims to determine the antibacterial activity of Jatropha sap against Escherichia coli and Staphylococcus aureus, to determine the antibacterial activity of jatropha hand sanitizer gel preparation against Escherichia coli and Staphylococcus aureus, and to find out the best formula for hand sanitizer gel from jatropha that has antibacterial effectiveness against Escherichia coli and Staphylococcus aureus. This research was conducted by formulating hand sanitizer gel from jatropha sap with various concentrations. Based on the research data, the best data obtained for the concentration of jatropha sap which has antibacterial activity against Escherichia coli and Staphylococcus aureus is 10% with inhibition values of 13,33 ± 0,57 and 12,86 ± 0,51 the best concentrations of gel preparations. Hand sanitizer from jatropha sap which has antibacterial activity against Escherichia coli and Staphylococcus aureus is 10% with inhibitory value of 12,63 ± 0,35 and 12,10 ± 0,17 and the best formula for hand sanitizer gel contains jatropha sap fence with a concentration of 5% with a diameter value of 6,36 cm, pH 4,89, a viscosity of 4,60 ± 0,14 Pa.S, a clear whitish color with a gel-shaped texture and a homogeneous preparation.

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Section: Viscosity Testmentioning

confidence: 99%

Formulation of Hand Sanitizer Gel Jatropha Sap (Jatropha curcas L) as Antiseptic

Siswati

Aryati

Narsa

2022

J. Trop. Pharm. Chem.

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“…Sediaan gel yang telah diformulasi, selanjutnya dilakukan pengamatan secara fisik meliputi bentuk/konsistensi, bau dan warna. Gel biasanya jernih dengan konsistensi setengah padat 16 .…”

Section: Uji Karakteristik Sediaanunclassified

“…Uji daya sebar dilakukan dengan cara, gel ditimbang 0,5 gram kemudian diletakkan di tengah kaca bulat berskala. Diatas gel diletakkan kaca bulat lain atau bahan transparan lain dan pemberat sehingga berat kaca bulat dan pemberat 150 gram, setelah itu didiamkan penyebarannya 16 .…”

Section: Uji Daya Sebarunclassified

Formulasi dan Uji Karakteristik Gel Hand Sanitizer dengan Variasi Konsentrasi Carbomer 940 sebagai Gelling Agent

Miftahatuzzakiyah

2022

J. of Pharm.

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This study aims to determine the effect of carbomer 940 on the characteristics of hand sanitizer gel.This study used experimental methods with variations in the concentration of carbomer 940, namely 0.1%; 0.5%; 1% and 1.5%, the characteristics test of gel preparations in the form of organoleptic test, homogeneity test, spreadability test and pH test. The data analysis used is descriptive statistical analysis in the form of calculating the mean and standard deviation. Analysis of the difference test was carried out using the Anova test. If the value between groups is significant (with a confidence level of 95%), further analysis is carried out using the least significant difference test (LSD) to see the differences between groups.The results showed that there was an effect of carbomer 940 on the characteristics of the preparation. Homogeneity test results showed all formulas were homogeneous. The results of the spreadability test showed a significant difference (P <0.05) in formula 1 (17.8 cm ± 2.3), formula 2 (7.0 cm ± 0.0) and formula 3 (4.8 cm ± 0.2). The pH test showed a significant difference (P <0.05) in formula 1 (6.1 ± 0.1) and formula 2 (6.6 ± 0.2).

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“…Faktor yang mempengaruhi daya lekat gel yaitu jumlah dan kekuatan matriks gel. Semakin banyak dan kuat matriks gel maka daya lekatnya akan meningkat dengan mekanisme putusnya ikatan hidrogen yang terjadi antara polimer dengan air sehingga ikatan antara sesama rantai polimer semakin kuat (Wijayanto et al, 2013 Pengujian sineresis adalah pengujian untuk melihat peristiwa keluarnya air dari dalam sediaan gel antiseptik dimana fase gel akan mengkerut sehingga cenderung memeras air keluar dari dalam gel, akibatnya gel nampak lebih kecil dan padat (Rohana et al, 2019). Hasil pengujian menunjukkan bahwa sediaan gel tidak mengalami pemisahan baik dari bahan pembawa maupun pelarutnya.…”

Section: Pengujian Antiseptikunclassified

FORMULASI DAN EVALUASI VARIASI BASIS GEL AIR PERASAN TEMUAWAK (Curcuma xanthorrhiza R.) SEBAGAI ANTISEPTIK TANGAN

Fathoni¹,

Edy²,

Jayanti³

2021

PHA

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Temulawak (Curcuma xanthorrhiza R.) is a plant that contains antimicrobial properties of essential oil and curcumin compounds. The purpose of this study was to formulate temulawak juice into gel preparations by varying the HPMC and Carbomer gel bases with each base concentration of 1%, testing the effectiveness of the antiseptic preparations and evaluating the physical preparations of the gel. This study used laboratory experimental methods. temulawak is soaked in aquadest then filtered and centrifuged to obtain temulawak juice and formulated in a gel preparation. Testing the effectiveness as a hand antiseptic using the replica method. The results showed that the temulawak water gel met the physical properties of the gel preparation which included organoleptic test, homogeneity test, pH test, spreadability test, adhesion test, and syneresis test. The percentage of colony decline using the HPMC base was 29.53% and the Carbomer base was 14.74%. This shows that the gel preparation of Temulawak juice cannot reduce the normal flora of the skin so that it does not affect an antiseptic for hands. Key Words : Antiseptic, gel preparations, Curcuma (Curcuma xanthorrhiza R.) ABSTRAK Temulawak (Curcuma xanthorrhiza R.) merupakan tanaman yang memiliki kandungan senyawa minyak atsiri dan kurkumin yang bersifat antimikroba. Tujuan dari penelitian ini untuk memformulasikan air perasan temulawak menjadi sediaan gel dengan memvariasikan basis gel HPMC dan Karbomer dengan masing-masing konsentrasi basis sebesar 1 %, menguji efektivitas antiseptik sediaan dan mengevaluasi sediaan fisik dari gel tersebut. Penelitian ini menggunakan metode eksperimental laboratorium. Temulawak direndam dengan aquadest kemudian disaring dan disentrifuse untuk mendapatkan air perasan temulawak dan diformulasikan dalam sediaan gel. Pengujian efektivitas sebagai antiseptik tangan menggunakan metode replika. Hasil penelitian menunjukkan bahwa gel air perasan temulawak memenuhi persyaratan sifat fisik sediaan gel yang meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat dan uji sineresis. Presentase penurunan koloni menggunakan basis HPMC sebesar 29,53 % dan basis Karbomer sebesar 14,74 %. Hal ini menunjukkan bahwa sediaan gel air perasan temulawak tidak dapat menurunkan jumlah flora normal kulit sehingga tidak memiliki efek sebagai antiseptik tangan. Kata Kunci : Antiseptik, sediaan gel, Temulawak (Curcuma xanthorrhiza R.)

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Formulasi Hand Sanitizer dari Ekstrak Biji Pangi (Pangium edule Reinw)

Cited by 5 publications

References 0 publications

Formulation of Hand Sanitizer Gel Jatropha Sap (Jatropha curcas L) as Antiseptic

Formulation of Hand Sanitizer Gel Jatropha Sap (Jatropha curcas L) as Antiseptic

Formulasi dan Uji Karakteristik Gel Hand Sanitizer dengan Variasi Konsentrasi Carbomer 940 sebagai Gelling Agent

FORMULASI DAN EVALUASI VARIASI BASIS GEL AIR PERASAN TEMUAWAK (Curcuma xanthorrhiza R.) SEBAGAI ANTISEPTIK TANGAN

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