Formulation and Characterization of Sodium Alginate g-Hydroxy Ethylacrylate Bio-Degradable Polymeric Beads: In Vitro Release Studies

Abstract

Novel type of highly swollen beads were prepared by grafting 2-hydroxyethylacrylate onto biodegradable Sodium alginate (SA) via free-radical polymerization using potassium persulphate as an initiator and Triprolidine hydrochloride as a model drug. Evidence of grafting was obtained by fourier transform infrared spectroscopic technique. Morphological properties of the beads were studied by SEM analysis. Thermal properties and crystallinity of the beads were characterized using differential scanning calorimetry and thermogravimetric analysis and X-ray diffraction techniques, respectively. Dissolution experiments were performed to study the release profiles at 37°C in phosphate buffer solution (pH-7.4). Effect of monomer content, crosslinking agent and drug/polymer ratio on swelling properties and release profiles were also comparatively studied. A dissolution result concludes that drug release decreases with increasing crosslinker content. The highest release (96%) was obtained for the beads prepared with 0.5 mL crosslinking agent. Equilibrium swelling degree also supports the drug release profiles confirming SA-g-HEA beads showed better release profiles compare to plain SA beads.

Manufactures of bio‐degradable and bio‐based polymers for bio‐materials in the pharmaceutical field

“…Due to their hereditary properties, especially in the field of biodegradability and non‐toxicity. Water‐soluble polymers, that is, cellulose, chitosan, sodium alginate, guar gum, and carboxymethyl starch are important biopolymers in the high permeability of the gel 1–3 . In the modern era, the demand for renewable energy sources has been reducing dependency on fossil fuel resources, which leads to many drawbacks.…”

The Fabrication of Alginate–Carboxymethyl Cellulose-Based Composites and Drug Release Profiles

“…These characteristics are related to the chemical structure of the alginate. Uronic acids can be structured in the form of heteropolymers (which contain blocks of mannuronic and guluronic acids) [10]. The proportion of mannuronic acid and guluronic acid M and G blocks and their structure significantly affect on the properties of alginate [11].…”

The Usages and Potential Uses of Alginate for Healthcare Applications

“…It has a unique formulation, factors responsible for their viscosity, sol/gel transition, and water uptake ability, and dissolves in water (Szekalska et al, 2016a). The alginic acid residues of alginate can be arranged in homogenous (poly-G, poly-M) or heterogeneous (MG) block-like patterns (Venkata Prasad et al, 2012). The length of the alginic acid residues, the ratio of M and G residues, and its properties depend on the desired functions of the alginate (Vara Prasad et al, 2016).…”