Formulation and evaluation of a topical liposomal gel containing a combination of zedoary turmeric oil and tretinoin for psoriasis activity

Ji, Chen; Ma, Yanqiao; Tao, Yueying; Zhao, Xiaoqian; Xiong, Yongai; Chen, Zehui; Tian, Yuan

doi:10.1080/08982104.2020.1748646

Cited by 37 publications

(20 citation statements)

References 36 publications

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“…From the data presented in our study, it can be hypothesized that some NSAIDs with non-selective COX inhibitor activity, such as diclofenac, and a more selective COX-2 inhibitor, such as celecoxib, have an anti-psoriasis effect comparable with tretinoin, in a mouse tail model. Retinoids (tretinoin) are well-known substances with anti-proliferative and anti-psoriasis effects in rodents' psoriasis models [20,21].…”

Section: Discussionmentioning

confidence: 99%

Anti-Psoriasis Effect of Diclofenac and Celecoxib Using the Tail Model for Psoriasis

et al. 2022

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Non-steroidal anti-inflammatory drugs (NSAIDs) showed effects in some hyperproliferative dermatologic pathologies. The aim of the study is the assessment of anti-psoriasis effect of diclofenac and celecoxib using a mice tail model. The topical application of substances on the proximal mice tails was performed for two weeks. The effects on the epidermal granular layer and mean epidermal thickness (excluding the stratum corneum) were evaluated using hematoxylin–eosin staining. Orthokeratosis degree and percentual drug activity were calculated. A positive control group treated with tretinoin and two negative controls (white soft paraffin and untreated mice) were used. Orthokeratosis degree significantly increased in all the NSAIDs groups (celecoxib 1%, 2% and diclofenac 1%, 2%) and in the tretinoin 0.05% group, versus negative controls. Celecoxib 1% and 2%, tretinoin 0.05% and white soft paraffin significantly increased mean epidermal thickness, versus untreated mice. The values obtained in the case of celecoxib 2% ointment regarding the orthokeratosis degree and percentual drug activity are providing premises for further investigations regarding this effect and the mechanisms of action involved. Celecoxib 2% had the greatest percentual drug activity and is a promising substance for the anti-psoriasis topical treatment. Along with the COX-2 inhibition, celecoxib might have an anti-psoriasis effect by other independent mechanisms.

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Section: Discussionmentioning

confidence: 99%

Anti-Psoriasis Effect of Diclofenac and Celecoxib Using the Tail Model for Psoriasis

et al. 2022

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“…Both B10 and B10 progenitor cells were correlated with the pathogenesis of psoriasis after Tretinoin (Vitamin A Acid, Retinoids) treatment Tretinoin is a classic drug for the treatment of psoriasis and is very effective in treating psoriasis [21,22]. To further understand the role of B10 cells and B10 pro cells in psoriasis, we followed up 15 patients with remission of symptoms after retinoic acid treatment.…”

Section: Elevated Plasma In Ammatory Cytokine Level In Psoriasis Pati...mentioning

confidence: 99%

Abolished TNF-α is crucial for the maintenance of B10 cells subsets in Psoriasis development

Zheng

Gao

2022

Preprint

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Background: Psoriasis is a common chronic skin disease characterized by epidermal proliferation and inflammation. Tumor necrosis factor α (TNFα) has a high degree of pro-inflammatory and can cooperatively regulate the pathogenic effect of other cytokines. TNFα inhibitors have shown effective in treating plaque psoriasis. IL-10 is closely related to the severity of psoriasis. Regulatory B cells (Bregs) that produce IL-10 are identified as negative regulators of the immune response, also known as B10 cells. At present, the contribution of B10 cells to the pathogenesis of psoriasis is unclear. Therefore, we used gene knockout mice, combined with data analysis of clinical psoriasis patients, to explore the role of TNFα and IL-10 regulating B10 cell function in the occurrence and development of experimental psoriasis evidence for the psoriasis clinical diagnosis and treatment.Results: The plasma inflammatory cytokine levels from psoriasis patients were higher than those in healthy controls. Impaired mature and immature B10 cell subsets in the peripheral of psoriasis patients, and both B10 and B10 progenitor cells were correlated with the pathogenesis of psoriasis after Tretinoin (Vitamin A Acid, Retinoids) treatment. Through the psoriasis models in TNFα knockout and wild-type mice induced by IMQ, It was found that the psoriatic lesions in TNFα knockout mice were slighter than those in wild-type mice, and the proportion of B10 and B10 precursor cells in the spleen of TNFα knockout mice decreased before and after IMQ induction. The expression level of IL-10 in the skin tissue of the TNFα KO mice model was significantly decreased in contrast to WT control after IMQ treatment. Conclusions: Our study was to explore the effect of the imbalance between B10 cells and TNFα on the pathogenesis of psoriasis from psoriatic patients' B10 cells and B10 precursor cells, combined with the psoriatic animal model. The mechanism by which TNFα affects B10 cells and B10 progenitor cells still need further study.

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“…Chen et al [47] studied the turmeric and tretinoinloaded liposome gels. Turmeric and tretinoin can be incorporated into liposomes with a highly stable entrapment efficiency, which markedly improves the solubility and stability of the drug.…”

Section: Liposomesmentioning

confidence: 99%

“…Skin penetration and retention studies have shown that liposomes greatly extend the duration of drugs in the hair follicles, as well as retained more drugs in the mouse skin. Importantly, the in vivo study for the efficacy of zedoary turmeric oil and tretinoin-loaded liposome gel is comparable to calcipotriol ointment on the market for the treatment of psoriasis [47]. Psoralen cationic liposomes and anionic liposomes were prepared by Doppalapudi.…”

Section: Liposomesmentioning

confidence: 99%

Natural medicine combined with nanobased topical delivery systems: a new strategy to treat psoriasis

Zhao

Liu

Zhu

et al. 2021

Drug Deliv. and Transl. Res.

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Psoriasis, an autoimmune inflammatory skin disorder, is one of the commonest immune-mediated disease conditions affecting individuals globally. At the moment, the conventional methods applied against psoriasis treatment have various drawbacks involving limited efficacy, skin irritation, immunosuppression, etc. Therefore, it is important for scientists to find a more potent and alternative drug approach towards psoriasis therapeutics. Natural medicine still remains an important source for new drug discovery due to its therapeutical significance in various drug administration routes. However, the traditional formulation of topical therapies for psoriasis is limited in efficacy, which limits the use of natural medicine. Based on the aforementioned limitations, the use of nanocarriers in preparation of these topical herbal products could be tremendously beneficial in enhancing the efficacy of topical medications. Growing pieces of evidence have proposed that the utilization of nanocarriers in transdermal preparation as a prospective technique, with regards to better potency, directs drug absorption to site of action, and minimum toxicity effect respectively. In the course of this review, we emphasized the pathological mechanism of psoriasis, natural medicine formula, active components of natural medicine, and nanopreparations used in the treatment of psoriasis.

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Formulation and evaluation of a topical liposomal gel containing a combination of zedoary turmeric oil and tretinoin for psoriasis activity

Cited by 37 publications

References 36 publications

Anti-Psoriasis Effect of Diclofenac and Celecoxib Using the Tail Model for Psoriasis

Anti-Psoriasis Effect of Diclofenac and Celecoxib Using the Tail Model for Psoriasis

Abolished TNF-α is crucial for the maintenance of B10 cells subsets in Psoriasis development

Natural medicine combined with nanobased topical delivery systems: a new strategy to treat psoriasis

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