Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer

Abstract

The present investigation reports the design and evaluation of six-hour extended release film-coated matrix tablets of cephalexin using different grades of hydrophilic polymer hydroxypropylmethylcellulose (HPMC) employing direct compression method. The preformulation studies performed included the physical compatibility studies, Differential Scanning Calorimetry analysis, drug characterization using Fourier Transform Infra Red spectroscopic analysis and particle size analysis using sieve method. The tablets were evaluated for weight variation, hardness, thickness and friability. Results of the studies indicate that the polymers used have significant release-retarding effect on the formulation. The dissolution profile comparison of the prepared batches P1 to P8 and market preparation (Sporidex AF 375) was done by using Food and Drug Administration-recommended similarity factor (f2) determination. The formulation P8 (10% HPMC K4M, 15% HPMC 15cps) with a similarity factor (f2) of 77.75 was selected as the optimized formulae for scale-up batches. The dissolution data of the best formulation P8 was fitted into zero order, first order, Higuchi and Korsemeyer-Peppas models to identify the pharmacokinetics and mechanism of drug release. The results of the accelerated stability study of best formulation P8 for three months revealed that storage conditions were not found to have made any significant changes in final formulation F3. The release of cephalexin was prolonged for 6 h by using polymer combinations of HPMC and a twice daily matrix tablet was formulated.

Venlafaksin Hidroklorürün Uzatılmış Salım Yapan Tablet Formülasyonlarının Geliştirilmesi ve Değerlendirilmesi

“…HPMC is a generally preferred polymer for sustained release, or sustained release tablet formulations with the advantage of to achieve drug release independently of the processing parameters (33). Some studies showed the effectiveness of HPMC and Carbopol for providing controlled drug release profile (34). When the drug release amount of two different formulations containing HPMC and Carbopol in the same amount was compared, it was observed that Carbopol decreased drug release compared to HPMC (28).…”

Central Composite Design Aided Formulation Development and Optimization of Clarythromycin Extended-Release Tablets

“…FT-IR spectroscopy (FT IR-8400-S Shimadzu, Japan) was engaged to determine the compatibility of drug with the excipients. 9 Pure drug and excipients were mixed Potassium bromide and compressed into discs and were run over in the series of 4000 to 400 cm -1 .…”

Formulation of Self-Nanoemulsifying Drug Delivery System of Cephalexin: Physiochemical Characterization and Antibacterial Evaluation

“…To improve solubility, bioavailability, and therapeutic efficacy, several CEP formulations have been developed. The formulations like immediate and sustained release formulations [3], controlled release matrix tablets [8], silica micro-particles [19], non-ionic microemulsions [5], extended-release matrix tablets [7,20], and gastro-floating tablets [6,21] have been developed and tested. The objective of the current research was to develop a CEP SNEDDS and evaluate it by a titration method.…”