Formulation and Evaluation of Chewable Tablets of Anti-Asthmatic Drug

Suruse, P. B.; Band, K. S.; Ingole, Ashwini; Baheti, Jagdish

doi:10.52711/0974-360x.2022.00022

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Chewable tablets are mostly chewed in the mouth before swallowing. The main aim of the chewable tablet is to give a proper unit dosage form of medication that can easily be given to children or to the elderly who have difficulty swallowing a tablet intact [ 11 , 12 ]. Chewable tablets are taken to disintegrate smoothly in the mouth at a moderate rate either with or without actual chewing; the properties of chewable tablets have a smooth texture upon disintegration, are pleasant tasting, and leave no bitter or unpleasant taste.…”

Section: Introductionmentioning

confidence: 99%

“…One or more approaches are followed to arrive at a combination of the formula and the process that result in a product with well-organoleptic properties. Such a substance must have acceptable flow, compressibility, and stability properties [ 11 , 12 ]. Many pregnant women and children do not prefer swallowing tablets based on an initial survey run by this study where 46% of the respondents are suffering from motion sickness and 39.3% are pregnant women and prefer to have a chewable formulation than the oral swallowed tablet.…”

Section: Introductionmentioning

confidence: 99%

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Formulation of New Chewable Oral Dosage Forms of Meclizine and Pyridoxine Hydrochloride

Al-Madhagi,

Alshargabi,

Alzomor

et al. 2023

Advances in Pharmacological and Pharmaceutical Sciences

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Nausea and vomiting are symptoms associated with a lot of diseases and oral tablets may be unprofitable for patients especially those suffering from nausea and vomiting. Therefore, this study aimed to formulate a new meclizine and pyridoxine combination formula for chewable tablets and provide rapid drug absorption and decrease motion sickness. The new chewable formulation has been prepared to provide fast action, is more acceptable, and could be used for all age categories. Seven trials haves been carried out to prepare to find the suitable one where formula 7 of the chewable gum preparation exhibited good taste and hardness, while the gelatin formulation give an accepted formula after four trials with better taste and good acceptance. The prepared formulations give a dissolution profile of meclizine (95.53–102.8%) and pyridoxine (99.25 ± 115%) and assay (98 + 0.05–99.3 ± 0.8%) for meclizine and (97 ± 0.9–100.0 ± 0.08%) for the pyridoxine in three prepared formulations of chewable tablets. Followed by the evaluation, the formulation and testing them on human volunteers are carried out to confirm their effect to ensure acceptance and fast actions. The finding is promising for preparing a new route of administration of meclizine and pyridoxine combination to be used in the market.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation of New Chewable Oral Dosage Forms of Meclizine and Pyridoxine Hydrochloride

Al-Madhagi,

Alshargabi,

Alzomor

et al. 2023

Advances in Pharmacological and Pharmaceutical Sciences

View full text Add to dashboard Cite

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Accuracy of Nasal House Dust Mite-Specific Immunoglobulin E in Diagnosis of Local Allergic Rhinitis

Rosalina,

Reno Pawarti,

Kristyono

et al. 2023

RJPT

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Background: Local allergic rhinitis (LAR) is the symptom of allergic rhinitis in which nasal allergen-specific immunoglobulin E(IgE) is detected but has no sensitivity to systemic allergens. The gold standard test is the nasal allergen provocation test (NAPT) which requires a complicated procedure. Specific IgE in nasal mucosa test is the less invasive and easier diagnostic alternative for LAR. Aims: This review aimed to determine the validity of the nasal house dust mite - specific IgE test for LAR patients. Study designs: A meta-analysis was conducted in chronic rhinitis patients with negative skin prick test (SPT) and serum IgE. Methods: The research was using PubMed Central, Cochrane library, SAGE journals, and Science Direct were searched until July 29th, 2022. The validity of the nasal HDM - specific IgE test was compared to NAPT. Results: A total of 413 research articles were selected and five articles were included. The QUADAS-2 assessment showed minimum publication bias. The total sample was 236 patients. Pooled sensitivity 90.00%, I2= 28.95% and p=0.01. Pooled specificity 96.00%, I2= 30.28% and p=0.00. The value of the area under the curve in the SROC curve = 0.9710, statistically significant. Conclusion: The nasal HDM- specific IgE test is valid for diagnosing patients with LAR.

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A Chewable Toothpaste Tablet: An Alternative approach to the Toothpaste

N.¹,

Surawase²

2022

RJPDFT

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Nowadays we have all become very aware of toothpaste and its usage. Currently in the market medicated and herbal toothpaste are available. It’s a huge competition for better results from toothpaste for the prevention of tooth problems. Recently daily use lots of dental products and after use, we throw the containers and closures straight in the trash bin without thinking like are they are reusable or not. This is the current case in our country India, comparatively, in other countries, there is a growing awareness about proper waste management and the production of eco-friendly products and reusable. According to a new report published by Allied Market Research, titled, “Toothpaste Tablet Market by Product Type, Flavour Type, Packaging Type, Distribution Channel, and Price Point: Global Opportunity Analysis and Industry Forecast, 2021–2030,” the global toothpaste tablet market size was valued at $45.6 million in 2020, and is projected to reach $90.3 million by 2030, registering a CAGR of 7.3% from 2021 to 2030. Global toothpaste tablets sales are expected to grow at a healthy Compound annual growth rate (CAGR) of over 6.1% during the study forecast period 2021-2031.The toothpaste tablets sales are expected to grow significantly in the coming years. There is a future need in our developing country, however, unfortunately, there is no proper control over this. This review article aims to explore dental problems with sparing on a modified tablet dosage form i.e., chewable tablet toothpaste which will be helpful to reduce plastic waste, will be eco-friendly, cost-effective, and improve dental health.

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Formulation and Evaluation of Chewable Tablets of Anti-Asthmatic Drug

Cited by 3 publications

References 6 publications

Formulation of New Chewable Oral Dosage Forms of Meclizine and Pyridoxine Hydrochloride

Formulation of New Chewable Oral Dosage Forms of Meclizine and Pyridoxine Hydrochloride

Accuracy of Nasal House Dust Mite-Specific Immunoglobulin E in Diagnosis of Local Allergic Rhinitis

A Chewable Toothpaste Tablet: An Alternative approach to the Toothpaste

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