Formulation and Evaluation of Chitosan-PLGA Biocomposite Scaffolds Incorporated with Quercetin Liposomes Made by QbD Approach for Improved Healing of Oral Lesions

Munot, Neha; Shinde, Yashwant Dattatraya; Shah, Pranav; Patil, Abhinandan; Patil, Sandeep B.; Bhinge, Somnath D.

doi:10.1208/s12249-023-02584-x

Cited by 11 publications

(11 citation statements)

References 51 publications

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“…In addition, the contour plot of the interaction between B – T and A – C tends to an elliptical shape. It indicates that the effects of B – T and A – C on the encapsulation rate of QUE-NL-1 are more significant . This result is consistent with the above analysis of the ANOVA.…”

Section: Results and Discussionmentioning

confidence: 99%

“…Previous studies have found that drug concentration, evaporation temperature, and lipid bile ratio dosage are key factors affecting the encapsulation efficiency of liposomes. Therefore, the drug concentration (0.05, 0.10, 0.15, 0.20, 0.25, 0.30, and 0.35 mg/mL), evaporation temperature (15,25,35,45, and 55 °C), and lipid bile ratio (2, 3, 4, 5, and 6) were optimized separately.…”

Section: Single-factormentioning

confidence: 99%

“…Response Surface Optimization Experimental Design. Three independent variables were selected: drug concentration (0.2, 0.25, and 0.3 mg/mL), evaporation temperature (25,35, and 45 °C), and lipid bile ratio (3, 4, and 5). The encapsulation efficiency was used as a key indicator to evaluate the quality of the response surface liposomes.…”

Section: Single-factormentioning

confidence: 99%

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Optimization of Preparation Conditions for Quercetin Nanoliposomes Using Response Surface Methodology and Evaluation of Their Stability

Liu,

Yu,

et al. 2024

ACS Omega

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Quercetin is a flavonol compound with excellent biological activities. However, quercetin exhibits poor stability and solubility in water, which limits its application. In this study, quercetin nanoliposomes (QUE-NL-1) were prepared using an ultrasonic thinfilm dispersion method, and the preparation conditions were optimized using response surface methodology. The optimal conditions for preparing QUE-NL-1 were as follows: an evaporation temperature of 35 °C, a drug concentration of 0.20 mg/mL, and a lipid bile ratio of 4:1. The encapsulation rate of QUE-NL-1 is (63.73 ± 2.09)%, the average particle size is 134.11 nm, and the average absolute value of the zeta potential is 37.50 and PDI = 0.24. By analyzing the storage temperature, storage time, and leakage rate of QUE-NL-1 in simulated gastrointestinal fluid, it was found that quercetin exhibits good stability after embedding and can achieve sustained release in intestinal juice. In addition, the cytotoxicity of QUE-NL-1 was not significant, and the survival rate of Caco-2 cells was >90% when the concentration range of QUE-NL-1 was 0.1− 0.4 mg/mL. This study provides an efficient method for preparing QUE-NL-1 with small particle sizes, good stability, and high safety, which is of great significance for expanding the application range of quercetin.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Single-factormentioning

confidence: 99%

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Optimization of Preparation Conditions for Quercetin Nanoliposomes Using Response Surface Methodology and Evaluation of Their Stability

Liu,

Yu,

et al. 2024

ACS Omega

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“…As probiotics break down nutrients, they make byproducts like short-chain fatty acids (SCFAs), vitamins, polyamines, and other bioactive chemicals. These molecules can change how cancer cells act in different ways [22][23][24][25][26][27][28][29][30][31][32][33][34][35] .…”

Section: Table 1 Impact Of Probiotics In Different Health Conditionsmentioning

confidence: 99%

“…Probiotics can change how much polyamines are made and how much is available. This may affect how cancer cells grow and live [25][26][27][28][29][30][31][32][33][34][35][36][37] .…”

Section: Table 1 Impact Of Probiotics In Different Health Conditionsmentioning

confidence: 99%

<strong>Knowing the Mechanisms: How Probiotics Affect the Development and Progression of Cancer</strong>

Patil,

Kotekar,

Chavan

2023

Preprint

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The stability of the gut barrier is very important for keeping the gut healthy and stopping dangerous substances from getting into the bloodstream. Several diseases, including cancer, have been linked to the gut barrier being broken. Live bacteria called probiotics that are good for the host have been shown to have the ability to improve the gut barrier and lower the risk of cancer in the gastrointestinal system. This review looks at how probiotics affect the health of the gut barrier and what that might mean for preventing cancer. Researchers have found that probiotics strengthen the connections between intestine cells, encourage the production of protective mucins, and change the make-up and balance of the gut bacteria. These processes help keep the gut barrier strong and stop harmful chemicals from getting into the bloodstream. Probiotics may help lower the chance of cancer by reducing inflammation throughout the body and protecting the GI tract from harmful substances. But more study is needed to fully understand the benefits of different probiotic strains, the best amounts to take, and how they affect the health of the gut barrier. Understanding how probiotics, the health of the gut barrier, and the risk of cancer all work together can help us come up with new ways to avoid and treat cancer.

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Design, Development and Optimization of 5-Fluorouracil Nanohydrogel for Improved Anticancer Therapy

Dange,

Salunkhe,

Honmane

et al. 2024

BioNanoSci.

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Formulation and Evaluation of Chitosan-PLGA Biocomposite Scaffolds Incorporated with Quercetin Liposomes Made by QbD Approach for Improved Healing of Oral Lesions

Cited by 11 publications

References 51 publications

Optimization of Preparation Conditions for Quercetin Nanoliposomes Using Response Surface Methodology and Evaluation of Their Stability

Optimization of Preparation Conditions for Quercetin Nanoliposomes Using Response Surface Methodology and Evaluation of Their Stability

<strong>Knowing the Mechanisms: How Probiotics Affect the Development and Progression of Cancer</strong>

Design, Development and Optimization of 5-Fluorouracil Nanohydrogel for Improved Anticancer Therapy

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