Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablets for Zidovudine and Lamivudine Combination Using Fructose as Osmogen

Sahoo, Chinmaya Keshari; Rao, Surepalli Ram Mohan; Sudhakar, M.

doi:10.22270/jddt.v7i4.1465

Cited by 7 publications

(7 citation statements)

References 9 publications

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“…The release of nicorandil was influenced by the differences in the osmotic pressure of the solutions on each side of the semipermeable membrane [23,24]. As a result, release experiments were conducted using dissolution media that had different osmotic pressures.…”

Section: Effect Of Osmotic Pressure On the Dissolution Mediummentioning

confidence: 99%

Osmotic Drug Delivery System of Nicorandil: Design and Evaluation

CHOUDHARY,

SUBRAHMANYAM,

PRIYANKA

2024

Int J App Pharm

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Objective: The purpose of the current research was to design a nicorandil formulation with controlled drug release using the principles of osmotic pump technology. Nicorandil is a biopharmaceutical classification system (BCS) class 3 drug, having a shorter plasma elimination half-life and bioavailability of 75 to 80%. Methods: The elementary osmotic pump (EOP) was prepared by coating a cellulose acetate polymer on the prepared core tablet. A 24-factorial design was applied to optimize the parameters for the osmotic tablet. A surface orifice was drilled. Results: Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) results showed that there was no interaction between drugs and excipients. A 24-factorial design was applied to optimize the parameters for the elementary osmotic pump. The optimized batch was characterized for in vitro drug release studies, and the effects of pH, osmotic pressure, and agitation intensity were analyzed. All the batches showed a drug release ranging from 90.48% to 98.78% after 12 hours. There was no change in the drug release pattern at different pHs and agitation intensities. The drug release was found to decrease with the increasing osmotic pressure of the dissolution medium. The results showed that the amounts of sodium chloride and mannitol were positively affecting the drug release, while the plasticizers PEG400 and DBP were not critical. Scanning electron microscopic studies (SEM) showed the integrity and surface morphology of the coating membrane before and after dissolution. The prepared EOP was found to deliver nicorandil at zero-order for up to 12 hours. Conclusion: Nicorandil was developed successfully as a controlled drug delivery during a 12-hour period, with variables optimized by the use of a 24-factorial design.

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Section: Effect Of Osmotic Pressure On the Dissolution Mediummentioning

confidence: 99%

Osmotic Drug Delivery System of Nicorandil: Design and Evaluation

CHOUDHARY,

SUBRAHMANYAM,

PRIYANKA

2024

Int J App Pharm

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“…Clear liquid was decanted and centrifuged at 12000 rpm for 45 min. 19 After centrifugation the supernatant was filtered through 0.45 µ whatman filter paper and after suitable dilution absorbance was measured in UV at 265nm; the concentration of drug was measured. All measurements were performed in triplicate.…”

Section: Determination Of Entrapment Efficiencymentioning

confidence: 99%

Development and Characterization of Terminalia arjuna Phospholipid Complex and Its Tablet Formulation by Qbd Approach

Saudagar¹,

Sidram²,

Baburo³

et al. 2022

Int J Life Sci Pharm Res

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Phytosomes are a newly introduced novel drug delivery system and novel botanical formulation to induce lipophilic molecular complexes to enhance absorption and bioavailability of phytoconstituents. Terminali aarjuna phospholipid complex and it’s tablet formulations targeted for cardiovascular systems was prepared. Our study aims is for improving the cardioprotective activity by formulating Terminalia arjuna phospholipid complex tablet by using solvent evaporation method. and characterized by various parameters like solubility studies, particle size determination, infrared absorption (FTIR), Scanning electron microscopy (SEM), entrapment efficiency etc. as well as by applying QbD approach various general characteristics such as entrapment efficiency etc were also done. A QbD- based approach using a Box-Behnken design was done to obtain a response surface design expert software 9.0.5 to systematically study the combined influence of the formulation and process variables such as the phospholipids-drug ratio(X1, w/w), the reaction temperature(X2, °C), and the reaction time (X3, hrs) on a critical quality attributes (CQAs) of the product i.e., the entrapment efficiency. Using this design, the experimental trials were carried out at all 15 possible combinations. The preliminary investigation of the influence of factors revealed that all the tested variables, i.e., the phospholipids to drug ratio, the reaction temperature and the reaction time had a significant influence on the entrapment efficiency of the prepared phytosomes. The study revealed that the entrapment efficiency of Terminalia arjuna Phytosomes was found to be 83.0-97.9 %w/w.

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“…Out of various controlled drug delivery systems floating drug delivery system utilizes principle of gastric retention time of the dosage forms at the stomach and upper part of the small intestine and suitable for the drug having site-specific absorption from the above sites and control the delivery of active ingredients. 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Development and in Vitro Evaluation of an Oral Floating Tablet of Metronidazole

Soni¹,

Ghulaxe²,

Upadhyay³

et al. 2018

J. Drug Delivery Ther.

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The present study was undertaken with an aim to develop and evaluate gastroretentive floating tablets of Metronidazole that are designed to retain in the stomach for a long time and have developed as a drug delivery system for better eradication of Helicobacter Pylori in peptic ulcer diseases. The floating tablets of Metronidazole were made by direct compression method using polymer Carbopol 934 and sodium bicarbonate and citric acid as gas generating agent. The tablets were evaluated by pre and post compression parameters such as weight variation, thickness, friability, hardness, drug content, in-vitro buoyancy studies and in-vitro dissolution studies and results were within the limits. Hardness was found to be in the range of 7.6 ± 0.27 kg/ cm² to 7.9 ± 0.35 kg/cm², the percent friability was in the range of 0.48% to 0.52% w/w and the tablets showed 94% to 97% uniformity in drug content. The in-vitro dissolution studies were carried out in a USP type-II apparatus in 0.1N HCl. The formulations were able to within 2-7 minutes and showed buoyancy >12 hrs. The drug-polymer ratio, viscosity grades of Carbopol 934 and gas generating agents were found to influence the release of drug and floating characteristics from the prepared floating drug delivery system of Metronidazole. Kinetically, among the 4 assessed models the release pattern of Metronidazole from the tablets fitted best to Higuchi's and zero order indicated that diffusion is the predominant mechanism controlling the drug release.

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Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablets for Zidovudine and Lamivudine Combination Using Fructose as Osmogen

Cited by 7 publications

References 9 publications

Osmotic Drug Delivery System of Nicorandil: Design and Evaluation

Osmotic Drug Delivery System of Nicorandil: Design and Evaluation

Development and Characterization of Terminalia arjuna Phospholipid Complex and Its Tablet Formulation by Qbd Approach

Development and in Vitro Evaluation of an Oral Floating Tablet of Metronidazole

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