Formulation and Evaluation of Controlled Release Floating Tablets of Cefixime Using Hydrophilic Polymers

Chakraborty, Tulshi; Natasha,; Saini, Vipin; Rubi,

doi:10.7897/2230-8407.100129

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Samples were withdrawn at defined time intervals and investigated for changes in physical appearance, drug content, buoyancy and in vitro drug release as per ICH Q1A guidelines. 22…”

Section: Stability Studiesmentioning

confidence: 99%

Formulation and in vitro Evaluation of Floating Tablets of Dicloxacillin Sodium Using Different Polymers

Chinthaginjala¹,

Barghav²,

Reddy³

et al. 2019

JYP

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Objectives: The purpose of the work was to develop gastro retentive floating tablets of Dicloxacillin sodium using different ratios of HPMC K 100M, Xanthan gum, Guar gum. Sodium bicarbonate is used as a gas generating agent. Dicloxacillin sodium is used to treat a wide variety of bacterial infections and has a half-life of about 2 hr. Methods: Gastro retentive floating tablets containing 270 mg of dicloxacillin sodium were prepared by wet granulation method employing different ratios of polymers. Results: The formulated tablets were evaluated for precompression parameters and were in the acceptable limits. Post-compression parameters such as weight variation, hardness, friability, swelling index, floating lag time and total floating time were also evaluated. The formulation F3 with HPMC K 100M showed 98.87% of drug release at the end of 12 hr, maintained integrity of tablets and have an optimum floating lag time of 90±0.14 sec and total floating time of 12 hr. The optimized formulation F3 was fitted to various kinetic models and the results showed that F3 formulation followed Zero order kinetics with an R 2 value of 0.993. The mechanism of drug release from F3 formulation was non-fickian diffusion. Conclusion: The study concluded that, among all the developed formulations, F3 formulation floated up to 12 hr with maximum drug release and can be considered as promising formulation.

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“…Samples were withdrawn at defined time intervals and investigated for changes in physical appearance, drug content, buoyancy and in vitro drug release as per ICH Q1A guidelines. 22…”

Section: Stability Studiesmentioning

confidence: 99%

Formulation and in vitro Evaluation of Floating Tablets of Dicloxacillin Sodium Using Different Polymers

Chinthaginjala¹,

Barghav²,

Reddy³

et al. 2019

JYP

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“…Cefixime trihydrate is chemically known as 7-{[2-(2-amino-1,3-thiazol-4-yl) 2(carboxy methoxyimino) acetyl] amino}-3-ethenyl-8-oxo5thia1-azabicyclo oct-2-ene-2carboxylic acid [1]. As shown in Figure 1, CFX is a thirdgeneration of some antibiotics such as ceftriaxone and cefotaxime [2]. CFX is more stable when beta-lactamase enzymes buried, that produced by positive gram-negative bacteria [3] [4].…”

Section: Introductionmentioning

confidence: 99%

Determination of Cefixime Using Batch, Cloud Point Extraction and Flow Injection as New Spectrophotometric Methods

Abood

Hassan

Al-Da’amy

2019

MJS

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Three simple, sensitive, selective, accurate and efficient spectrophotometric methods for determining cefixime in bulk drug and pharmaceutical formulations have described. The first method involved conversion of NH 2 in cefixime to diazonium salt, which has coupled with Bisphenol A in an alkaline medium. The orange colored product showed λ max at 490 nm and followed Beer's law over a concentration range of 1-50 μg mL -1 , with molar absorptivity of 0.866×10 4 L.mol -1 .cm -1 and the detection limit was 0.157 µg.mL -1 . The second method involved pre-concentration of a trace amount of cefixime-azo dyes using cloud point extraction (CPE). The extracted drugdye was spectrophotometrically measured at λ max 500. The constructed calibration curve to determine cefixime followed Beer's law in a range of 0.25-6 µg.mL -1 , with a correlation coefficient of 0.9998, molar absorptivity of 0.961×10 5 L.mol -1 .cm -1 and the detection limit was equal to 0.031 µg.mL -1 . The pre-concentration factor was 25 and distribution coefficient (D) was 314.03. A diazotization of the studied drug (cefixime) and its coupling with Bisphenol A was studied using a developed flow injection analysis method, based on the detection of the absorption of the diazotization product. Chemical and physical properties [of what??] were studied to develop the suggested method and to determine the stability of the colored of product. A flow rate of 2.5mL.min -1 , 50cm reaction coil and 100µL sample volume were used to operate the system and the orange colored product was detected at 490nm. The proposed three methods were successfully applied to determine cefixime in pharmaceutical formulation, where results were satisfactory

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Formulation and Evaluation of Controlled Release Floating Tablets of Cefixime Using Hydrophilic Polymers

Cited by 2 publications

References 16 publications

Formulation and in vitro Evaluation of Floating Tablets of Dicloxacillin Sodium Using Different Polymers

Formulation and in vitro Evaluation of Floating Tablets of Dicloxacillin Sodium Using Different Polymers

Determination of Cefixime Using Batch, Cloud Point Extraction and Flow Injection as New Spectrophotometric Methods

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