Formulation and Evaluation of Fast Dissolving Buccal Film of Enalapril Maleate

Abstract

In the development of buccal drug delivery system, mucoadhesion i.e.; the binding to mucin layer of biological membrane is the key element. Buccal film delivery system consist of at thin film, which is simply placed on the patient's tongue or mucosal tissue, instantly wet by saliva; the film rapidly dissolves, then it rapidly disintegrates and dissolves to release the medication for oral mucosal absorption. Here 5 Formulations of Enalapril Maleate oral films were formulated and produced by using solvent casting technique using the polymer hydroxyl propyl methyl cellulose based on various polymer excipients ratio and were evaluated. The infrared spectra showed stable and compatible character of the drug with the excipients and polymer. The F1 formulation was found to be the best formulation. The Formulation 1 with HPMC 250mg showed optimum swelling properties, maximum drug release and residence time.

Formulation, Optimizationandevaluation of Sublingual Film of Enalaprilmaleate Using 32 Full Factorial Design

“…Also reported in previous studies by Irene Thomas et al developed the formulation of fast dissolving buccal films of Enalapril maleate using hydroxyl propyl methyl cellulose as polymer which showed 99.8 % release of drug at 10 min. It is found to be same as compared to our present study but it is known to us that sublingual route of administration is preferred as compared to buccal route of administration [30].…”