Formulation and Evaluation of Flurbiprofen Oral Film

Abd-Alhammid, Shaimaa N.; H.Saleeh, Haider

doi:10.31351/vol23iss1pp53-59

Cited by 7 publications

(1 citation statement)

References 9 publications

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“…A propionic acid derivative, Flurbiprofen was a nonsteroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic activity. Oral formulations of Flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis 4 . In this study, various formulation trails of flurbiprofen sodium tablets were prepared using three super disintegrants: croscarmellose sodium, sodium starch glycolate, crospovidone and sublimating agent thymol.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

IJPSR

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The present work aimed to prepare flurbiprofen tablets using different concentrations of super disintegrants like croscarmellose sodium, sodium starch glycolate cross povidone sublimating agent thymol. Methods: The tablets were prepared by direct compression and sublimation technique using different concentrations of super disintegrants. The prepared tablets were evaluated for different parameters like hardness, friability, weight variation, thickness, content uniformity, wetting time, disintegration time, and dissolution study. Morphology of pure drug and optimized formulation were revealed by using SEM. Results: All the formulations prepared with the highest concentration of super disintegrant showed the highest drug release. Formulations from F11 to F13 were prepared with the sublimation technique. F11 formulation showed the highest drug release because of its porous nature, which resulted from the sublimation technique. Conclusion: The optimized formulation of the sublimation method (F11) was porous in nature. In-vitro drug release of all formulations prepared with the highest concentration of super disintegrant showed higher drug release than lower concentrations. The formulations prepared by the sublimation technique showed good drug release compared to the direct compression method.

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Section: Introductionmentioning

confidence: 99%

Untitled

2022

IJPSR

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In Vitro/In Vivo Evaluation and Bioavailability Study of Amitriptyline Hydrochloride from the Optimized Oral Fast Dissolving Films

Salman

Maraie

Alabbassi

et al. 2014

PBJ

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The present investigation was undertaken with the objective of developing fast dissolving film(s) of a tricyclic antidepressant drug amitriptyline hydrochloride in order to improve its bioavailability, optimize its therapeutic action especially when used to treat major depression and to enhance the compliance for the developmentally disable, mentally ill, elderly and pediatric patients. , the study based on cross over design using experimental animals (rabbits). The pharmacokinetic results revealed that the fast dissolving films has higher peak blood concentration (C max , 0.927µg/ml) within shorter time (T max, 2 hours), indicating rapid absorption and faster onset of action with acceptable bioavailability value. These findings suggest that the fast dissolving film containing amitriptyline hydrochloride is expected to become one of choices for the treatment of acute depression.

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Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips

Khalil¹

2017

IJPS

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An oral bi layer sustained release (SR) strips of Sodium Montelukast SMLT , which is selective leukotriene antagonist , used for patients suffered from mid-night asthma , were prepared successfully ,using different polymers, like guar gum , carrageenan , and xanthan gum , by solvent casting method . The results obtained by this study revealed ,that best fast dissolving film of SMLT was loaded in carrageenan polymer 57% w\w (30mg.) , with acceptable physical properties, like film thickness , elastic endurance and surface pH . Besides to that , the disintegration time , and cumulative 80% drug release were estimated 22 seconds and 3.7 minutes , respectively .On the other hand , the sustained release film ( FSR6-7 ) as a second layer , appear to be the most promised layer of SMLT loaded in 50 % w\w (15mg.) PVP K17 , with respect to its film thickness, elastic endurance and , surface pH . Moreover the , the disintegration time of the second layer film was 21seconds , and the time for 50% drug release was 15 minutes extended for 4hours of 100% drug release . Meanwhile , the investigation of possible interference between the drug , and, polymers used revealed no evidence of this effect ,using FTIR , and SEM technique . In an attempt to evaluate the extended release effect of the selected formula , SingulairÂ® plain tablet as a marketed product was used , the result gave more than 4 hours of selected formula , compared with 30 minutes to marketed product SingulairÂ® . The overall results candidates the selected FSR6-7 formula as a promised bi layer buccal fast , as compliance and extended therapy for asthmatic mid- night patients. Keywords: Montelukast sodium, Dual buccal strips, Guar gum, Xanthan gum, Carrageenan.

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Formulation and Evaluation of Flurbiprofen Oral Film

Cited by 7 publications

References 9 publications

Untitled

Untitled

In Vitro/In Vivo Evaluation and Bioavailability Study of Amitriptyline Hydrochloride from the Optimized Oral Fast Dissolving Films

Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips

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