Formulation and evaluation of hyaluronic acid-based mucoadhesive self nanoemulsifying drug delivery system (SNEDDS) of tamoxifen for targeting breast cancer

Papain decorated multi‐functional polymeric micelles for the targeted intracellular delivery of paclitaxel

“…It was observed that the papain functionalized thiolated redox micelles (PT‐R‐Ms) based on papain grafted thiolated hyaluronic acid‐pluronic F127 disulfide‐linked lithocholic acid (Pap‐THA‐F 127 ‐SS‐LCA) readily exhibited the fastest diffusion in the mucus and displayed the largest diffusion areas (34 mm) up to last segment 20 (as shown in Figure 6B). However, papain functionalized redox micelles (P‐R‐Ms) mediated by Pap‐HA‐F 127 ‐SS‐LCA exhibited limited penetration up to 2‐12 segments 35 . Previously reported work revealed that thiol moieties immobilization on polymeric backbone enhances the particles mucus adhesive characteristics owing to its improved mucoadhesive strength 36 .…”

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

“…A droplet of SNEDDS nano emulsion formulation was placed on the carbon-coated copper stubs and stained with phosphotungstic acid solution (2% w / w ) operational under vacuum at 40 mA for 15 sec [ 25 ]. SEM and TEM of the HA-CIP SNEDDS and HA-SNEDDS was carried out using (FEI Nova Nano SEM 450, St. Louis, MO, USA) SEM equipped with TEM by employing the samples on the carbon-coated copper grid smudged by a drop of 1% ammonium molybdate solution.…”

“…Therefore, an appropriate ratio of HA polymer, oil, surfactant, and co-surfactant was mixed followed by probe sonication (20K HZ) for 5 min at 50 • C. After complete mixing of all above-mentioned excipients, the excess quantity of CIP was added, and the reaction mixture was vortexed for aided solubilization. Furthermore, the resulting polymeric HA-CIP-SNEDDS was cooled and stored at the room temperature to observe its stability [25].…”

In vitro characterization of a synthetic polyamide-based erodible compact disc for extended drug release

“…Generally, conventional dosage forms/delivery systems are commonly known to utilize high drug doses, most of which is often excreted without exerting any preferred biological activity except for undesired adverse reactions. Hence, scientific advancements continually detail the concept of polymer-based, modified drug delivery approaches that function as facilitators for timed release and site-specific administration, favouring therapeutic performance and patient convenience, not frequently offered by conventional medicines [1][2][3][4]. Drug delivery encompasses the use of novel technologies suitable for presenting bioactive molecules to preferred in vivo administration sites to facilitate absorption or transport across biological membranes, bioavailability and pharmacological efficacy [1,5].…”

“…Consequently, improving the safety and pharmacological performance of conventional medicines/dosage form by reformulating them into improve delivery systems are often quicker, cheaper and well-known to aid anticipated treatment outcomes [6]. This led to the invention of novel drug carriers that are capable of facilitating modified release, absorption, bioavailability, distribution, metabolism and elimination with the end goal of optimizing effectiveness, patient adherence and safety [1,4,[6][7][8][9].…”