Formulation and evaluation of Norfloxacin gastro retentive drug delivery systems using natural polymers

: Febuxostat is a novel, orally administered, powerful, non-purine, xanthine oxidase inhibitor used for treating gout and ceaseless tophaceous gout. The drug exhibits low bioavailability (about 49%) which is ascribed to its dissolution rate limited absorption. The aim of the current work was to provide a novel strategy to improve the dissolution profile and thus, bioavailability of Febuxostat. Formulation of fast dissolving tablets (FDT) is anticipated to provide immediate release of drug, which in turn, will improve its dissolution profile to provide the initial surge in plasma concentration required in acute gout attack. Incorporation of co-processed excipients in a tablet is known to improve the compressibility and disintegration characteristics of the tablets, which, in turn, result in enhanced in vitro drug release and improved bioavailability. A combination of crospovidone (it rapidly wicks saliva into the tablet to create the volume development and hydrostatic weight important to give quick disintegration) and microcrystalline cellulose (highly compressible ingredient with good wicking and absorbing capacity) was, therefore, used as co-processed excipients. The tablets were prepared by direct compression technique with the application of a 32 randomized full factorial design. The prepared tablets were able to release more than 80% of the drug within 10 minutes of the start of dissolution testing and were able to show better drug release profile in comparison to available marketed formulation.

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“…This test was performed by sampling and weighing 20 tablets at random from each batch and the average weight was calculated [ 19 , 20 ].…”

Section: Methodsmentioning

confidence: 99%

Formulation and in vitro Evaluation of Fast Dissolving Tablets of Febuxostat Using Co-Processed Excipients

Kaur

Mittal

Gulati

et al. 2020

DDF

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“…A formulation which exhibited 99.87% of drug release in 12 h, and floating lag time of 130 s with a floating time of 24 h was considered as ideal formulation and no drug-excipient interaction in the prepared formulations was confirmed by fourier transform infrared spectroscopy studies. [ 86 ]…”

Section: Guar Gummentioning

confidence: 99%

Role of excipients and polymeric advancements in preparation of floating drug delivery systems

Kaushik

Tiwari

Gaur

2015

Int J Pharma Investig

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Since decade or two, the development of floating drug delivery systems becomes a significant and novel tool as having low density than gastric content. There are various advanced polymers including chitosan, eudragit, etc., and excipients such as; pore forming agent, surfactants, etc. All of them are discussed briefly, and results are concluded from various reputed researches. We have discussed all natural and synthetic systems with their effect on the release and other parameters which are essential for the floating formulation development.

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“…Determination of drug content (Thahera et al, 2012) Five Ciprofloxacin tablets were crushed into powder in a mortar and powdered equivalent to ciprofloxacin dose was taken in a volumetric flask containing distilled water and kept aside with constant shaking on a rotary shaker for 24 h to extract the total drug present in the tablet. Then the absorbance of the solutions was measured after suitable dilution at 271 nm against distilled water as blank.…”

Section: Friability Testmentioning

confidence: 99%

Formulation and evaluation of colon specific microbial degradable matrix tablet using sterculia gum as carrier

2012

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Current study is to develop the colon targeted matrix tablet using the natural polysaccharide sterculia gum as carrier and model drug ciprofloxacin HCl. The matrix tablets were prepared by wet granulation technology using the various proportions of sterculia gum with carbopol 934 P, sterculia gum and ethyl cellulose polymer blends. Granules of all formulations were evaluated for rheological, post compressional properties and in vitro dissolution study in different pH buffers of pH 1.2 , pH 7.4 , pH 6.8 (saline phosphate buffer) without and with 4% rat cecal content in order to mimic GIT condition . Formulation SGC2 to SGC4 and SGE7 to SGE9 has released 13.6% to 38.9% in the initial 5h and released more amount of drug in stomach and small intestine than colon. Formulation SGC5 containing 45% of sterculia gum and 25% carbopol 934 p and Formulation SGE10 containing 45% of sterculia gum and 25% ethyl cellulose has released minimum 10.91 % to 13.04 % in the initial 5h and sustained the drug release up to 24 h and at the end of study released 75% to 79.99%. Formulations with 4% rat cecal content at the end of 24 h study drug released is 90.44% to 95.33% indicating higher amount of drug release is due to enzymatic break down of sterculia gum in the matrix tablet. Hence the above results conclude that the formulation SGC5 and SGE10 are potential in targeting the drug to colon to treat irritable bowel disease.DOI: http://dx.doi.org/10.3329/icpj.v1i11.12064 International Current Pharmaceutical Journal 2012, 1(11): 376-383

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Formulation and evaluation of Norfloxacin gastro retentive drug delivery systems using natural polymers

Cited by 21 publications

References 6 publications

Formulation and in vitro Evaluation of Fast Dissolving Tablets of Febuxostat Using Co-Processed Excipients

Formulation and in vitro Evaluation of Fast Dissolving Tablets of Febuxostat Using Co-Processed Excipients

Role of excipients and polymeric advancements in preparation of floating drug delivery systems

Formulation and evaluation of colon specific microbial degradable matrix tablet using sterculia gum as carrier

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