Role of excipients and polymeric advancements in preparation of floating drug delivery systems

Kaushik, Avinash Y.; Tiwari, Ajay Kumar; Gaur, Ajay

doi:10.4103/2230-973x.147219

Cited by 51 publications

(40 citation statements)

References 70 publications

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“…Floating time is also affected by the solubility of the polymer used as a matrix. The longer the matrix is dissolved in the medium, the longer the matrix floats on the surface of the medium [12].…”

Section: Resultsmentioning

confidence: 99%

Formulation of Metformin HCl Floating Tablet using HPC, HPMC K100M, and the Combinations

2017

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Diabetes Floating tablet is one of the most suitable dosage forms that used for delivering long term drug release. The objective of this study was to evaluate Hydroxypropyl cellulose (HPC), Hydroxypropyl Methyl Cellulose (HPMC) K100M, and the combination as matrix in manufacturing floating tablets. Metformin HCl, an anti-diabetic, was used as a drug model. Metformin HCl floating tablet was manufactured by wet granulation method in three formulas using variation of matrix, which were 40% of HPC (F1), 40% of HPMC K100M (F2), combination of 20% HPC and 20% HPMC K100M (F3). Prior to tablet compaction, evaluation for granules were done which included moisture content, angle of repose using, bulk and tapped density, Hausner ratio, and compressibility. The evaluations of floating tablet were physical properties, floating ability, and in vitro drug release. The average of floating lag time for F1, F2, F3, were 7 minutes 13 seconds; 5 minutes 27 seconds; and 14 minutes 5 seconds, respectively. In addition, the floating time for F1 was 3 hours 16 minutes whereas F2, F3 were more than 48 hours. F2 showed the best floating ability to retain the drug release, which was 84.68% over 8 hours, while F1 and F3 were completely dissolved less than 6 hours.

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Section: Resultsmentioning

confidence: 99%

Formulation of Metformin HCl Floating Tablet using HPC, HPMC K100M, and the Combinations

2017

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“…Acacia had gel forming mechanism in which it swells rapidly in contact with gastric fluid and maintains the shape integrity and bulk density less than the gastric content [26].…”

Section: Discussionmentioning

confidence: 99%

“…Eudragit RS 100 was in granular form and it used more widely than any other polymers, in which it is pH-independent swelling polymer with good mucoadhesive properties [26]. Eudragit RS 100 sustains the release of candesartan cilexetil from the matrix system by floating mechanism.…”

Section: Discussionmentioning

confidence: 99%

Effect of Natural and Synthetic Polymers on the Properties of Candesartan Cilexetil Matrix Tablet Prepared by Dry Granulation

Salih

Nief

2016

Asian J Pharm Clin Res

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Objective: The objective of this study is to develop a controlled release matrix tablet of candesartan cilexetil to reduce the frequency of administration, enhance bioavailability and improve patient compliance; a once daily sustained release formulation of candesartan cilexetil is desirable. Methods:The prepared tablets from F1 to F24 were evaluated with different evaluation parameters like weight variation, drug content, friability, hardness, thickness and swelling ability. In vitro release for all formulas were studied depends on the type and amount of each polymer, i.e. (16 mg, 32 mg and 48 mg) respectively beside to the combination effect of polymers on the release of the drug from the tablet. Results:In vitro release showed that formula 13 had the faster release (100% after 4 h) which contained acacia (1:1) and the lowest sustain release was showed for F7 (73% after 8 h) which contained HPMC K100M (1:1). Formula 1 was an 89 % release after 8 h which contain eudragit RS100; F4 was a 100 % release after 5 h which contain Na CMC, F10 was a 100% after 8 h which contain xanthan gum and F16 was a 100 % release after 5 h which contain tragacanth polymer. Formula 9 had a lower release than F7 and F8 respectively. Formula 7 can be used for sustain oral drug delivery of candesartan cilexetil while Formula 13 can be used in contrary as fast release tablets for faster response. Conclusion:Controlled drug delivery system is promising for less dosing and higher patient compliance.

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“…[25,26] Effervescent agent Sodium bicarbonate, citric acid, tartaric acid, nitroglycerin, and Di-sodium glycine carbonate are used as an effervescent agent to release carbon dioxide gases. [27] Inert fatty materials…”

Section: Wet Granulation Methodsmentioning

confidence: 99%

Untitled

2020

IJPBA

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Floating drug delivery approach uses low-density systems that have sufficient buoyancy to flow over the gastric contents and remains buoyant in the stomach without affecting the stomachic emptying rate for a chronic period of time. This result is increased gastric retention time and better control of the fluctuations in plasma drug concentration with a low risk of toxicity. Drugs, which are locally active in the stomach, drugs having narrow absorption window and unstable in the intestine, and colonic environment, are the potential drug candidates. The approach not only improves drug absorption but also minimizes the mucosal irritation of drugs. As the approach requires a high fluid level in the stomach to float and work efficiently, it makes the approach limited up to some extent. Many buoyant systems have been developed based on granules, powders, capsules, tablets, laminated films, and hollow microspheres and few formulations have been commercialized in the market at the present time. This review gives an overview of the approach of floating drug delivery at present with sequential demystification thus enabling a greater understanding of their role in medicine and drug delivery.

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Role of excipients and polymeric advancements in preparation of floating drug delivery systems

Cited by 51 publications

References 70 publications

Formulation of Metformin HCl Floating Tablet using HPC, HPMC K100M, and the Combinations

Formulation of Metformin HCl Floating Tablet using HPC, HPMC K100M, and the Combinations

Effect of Natural and Synthetic Polymers on the Properties of Candesartan Cilexetil Matrix Tablet Prepared by Dry Granulation

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