Formulation and Evaluation of Red Palm Olein Nanoemulsion

Sari, Febia; Sinaga, Kasmirul Ramlan; Siahaan, Donald

doi:10.22159/ajpcr.2018.v11i9.26532

Cited by 9 publications

(9 citation statements)

References 5 publications

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“…There are two methods to make nanoemulsion, low-energy and high-energy methods. Sari et al (2018) have been successfully made nanoemulsion by spontaneous emulsification method (low energy) with 5% red palm olein with 40% surfactant Tween 80 and 20% cosurfactant sorbitol [15] while another study suggests that the use of Ultra-Turrax (high energy) is a good strategy to prepare nanoemulsion [16].…”

Section: Discussionmentioning

confidence: 99%

A Preparation, Characterization, and in Vitro Skin Penetration of Morus Alba Root Extract Nanoemulsion

Fadhila

Jufri

2019

Asian J Pharm Clin Res

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Objective: White mulberry (Morus alba) root extract has terpenoid, flavonoid, and stilbene compounds. The stilbenes, oxyresveratrol and resveratrol, have antioxidant and antityrosinase activities. Nanocarriers can help active ingredients to be delivered in a more efficient manner. The advantages of nanoemulsion on products include increased penetration, biocompatibility, and low toxicity due to its non-ionic properties and have the ability to combine the properties of lipophilic and hydrophilic active ingredients. The objective of this study was to prepare, characterize, and evaluate the in vitro skin penetration of M. alba root extract nanoemulsion. Methods: The M. alba root extract was prepared by ionic liquid-based microwave-assisted extraction method. Nanoemulsion was optimized and prepared using virgin coconut oil (VCO), Tween 80, and polyethylene glycol 400 (PEG 400) by aqueous phase-titration method to construct pseudoternary phase diagram. M. alba root extract nanoemulsion was characterized for droplet size, viscosity, zeta potential, and physical stability tests for 12 weeks. In vitro skin penetration of oxyresveratrol from nanoemulsion was determined by the Franz diffusion cell and was compared by macroemulsion preparation, then analyzed by high-performance liquid chromatography method. Results: Based on pseudoternary phase diagram, nanoemulsion of white mulberry root extract contained of 2% VCO and 18% mixture of surfactant Tween 80 and PEG 400 (1:1) was chosen. Nanoemulsion has average globule size of 81.61 nm, with polydispersity index 0.22, and potential zeta −1.56 mV. The cumulative penetration of oxyresveratrol from nanoemulsion was 55.86 μg/cm2 with flux of 6.53 μg/cm2/h, while regular emulsion was 32.45 μg/cm2 with flux of 3.5501 μg/cm2/h. Conclusion: Nanoemulsion of white mulberry root extract was penetrated deeper than regular emulsion.

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Section: Discussionmentioning

confidence: 99%

A Preparation, Characterization, and in Vitro Skin Penetration of Morus Alba Root Extract Nanoemulsion

Fadhila

Jufri

2019

Asian J Pharm Clin Res

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“…Nanoemulsion was formulated by using variations of Tween 80 and sorbitol concentration. The nanoemulsions were formulated by using spontaneous emulsification method [12]. Emulsion system consists of an oil phase and water phase.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Evaluation of Sunflower Oil Nanoemulsion As a Sunscreen

Arianto¹,

Cindy²

2019

Open Access Maced J Med Sci

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BACKGROUND: There are a lot of different types of sunscreen products (oils, sticks, gels, creams, lotions) which can be found on the world's market. Sunscreen product that contains active chemical ingredients sometimes has harmful effects on the skin. Sunflower oil contains vitamin E and acts as a natural sunscreen which can absorb UVB light. The average droplet size of nanoemulsion is between 100 and 500 nm and do not show the problems of stability (creaming, flocculation, coalescence, and sedimentation), which are commonly associated with macroemulsions. AIM: The aim of this study was to prepare and evaluate the sunflower oil nanoemulsion as a sunscreen. METHODS: Sunflower oil nanoemulsions were prepared by spontaneous emulsification method with 3 formulas F1 (Tween 80 38%, sorbitol 22%), F2 (Tween 80 36%, sorbitol 24%), F3 (Tween 80 34%, sorbitol 26%) and 5% sunflower oil as a sunscreen substance. The nanoemulsions were evaluated for particle size, physical stability in room temperature (25 ± 2°C), low temperature (4 ± 2°C) and high temperature (40 ± 2°C) during experiment for 12 weeks of storage, centrifugation at 3750 rpm for 5 hours, viscosity, pH, freeze-thaw test and sun protection value (SPF) value by in vitro. RESULTS: The results of nanoemulsion evaluation showed that nanoemulsion formula F1 had the smallest average particle size of 124.47 nm with yellowish colour, clear, transparent, pH value (6.5 ± 0.1), viscosity value (225 ± 25 cP), did not show any separation or creaming in the centrifugation, and stable during experiment for 12 weeks of storage at room temperature, low temperature and high temperature. The SPF value of all nanoemulsion preparations was higher than that of the emulsion. CONCLUSION: The preparation of the sunflower oil nanoemulsion with a ratio of Tween 80 and sorbitol (38: 22) produces a stable nanoemulsion during the experiment for 12 weeks storage at the room, low and high temperature. The nanoemulsion preparation has higher SPF values compared to the emulsion. This nanoemulsion formulation could be considered more effective in sunscreen cosmetic use compare to the emulsion.

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“…The working principle of the tool is to use Laser Diffraction (LAS), which is when the particles pass through the laser beam and the light scattered by the particles is collected beyond the range of angles that are directly opposite each other. The distribution of these scattered intensities which will be analyzed by the computer as a particle size distribution [17].…”

Section: Organoleptic Examinationmentioning

confidence: 99%

Formulation and Evaluation of Liposome Moringa Oleifera Seed Oil (Moringa oleifera L.) as Anti-aging

Hartini

Sumaiyah

Hasibuan

2022

International Journal of Science, Technology & Management

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Moringa oil is a natural vegetable oil obtained from the juice of the ripe kernels of the Moringa tree (Moringa oleifera L). Moringa seeds have an oil content of up to 40%, and have antioxidant activity with vitamin E content reaching 51% but have low stability. The purpose of this study was to find the best formulation as an anti-aging on liposome delivery system with a ratio of phosphatidylcholine soy lechitin and cholesterol. The method used is thin layer hydration (Thin Film Hydration). The results of the observation on the best formula are the 6th formula on organoleptic examination which is milky yellow in color, has a distinctive smell of lecithin and cholesterol and is in the form of a thick suspension, with a pH of 6.0, particle size 83.98nm using a particle size analyzer and entrapment efficiency of 96.8 % using a UV-Vis spectrophotometer.

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Formulation and Evaluation of Red Palm Olein Nanoemulsion

Cited by 9 publications

References 5 publications

A Preparation, Characterization, and in Vitro Skin Penetration of Morus Alba Root Extract Nanoemulsion

A Preparation, Characterization, and in Vitro Skin Penetration of Morus Alba Root Extract Nanoemulsion

Preparation and Evaluation of Sunflower Oil Nanoemulsion As a Sunscreen

Formulation and Evaluation of Liposome Moringa Oleifera Seed Oil (Moringa oleifera L.) as Anti-aging

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