Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension

Abstract

Diabetes mellitus (DM) and hypertension are two common diseases that often coexist. The most common cause of death in the diabetic patient is heart disease. In the present investigation we combine Nebivolol and Nateglinide for better patient compliance. IR layer was formulated using various superdisintegrants like Crospovidone, Croscarmellose sodium, and sodium starch glycolate and SR layer was formulated using polymers and gums like HPMC E15, ethyl cellulose, Gaur gum, and Xanthan gum. The disintegration and dissolution study of both layers showed that inclusion of surfactant (sodium lauryl sulphate) to the tablet formulation (IR) and dissolution medium (SR) enhanced the release of drugs from both layers. Kinetic studies of optimized IR layer (NBL8) and SR layer (N9) showed good linearity with regression coefficient of 0.9714 (Higuchi model) and 0.9931 (zero order kinetics), respectively. The above results reveal that the optimized IR layer of Nebivolol (NBL8) and SR layer of Nateglinide (N9) might be suitable for the treatment of diabetes and hypertension by sequential release of the two drugs in a bilayer tablet. IR-immediate release, SR-sustain release, NBL8-Nebivolol 8, N9-Nateglinide 9.

Formulation and In-vitro Evaluation of Bilayer Tablets of Atenolol and Amlodipine

“…The physicochemical parameters of amlodipine tablets (e.g. weight variation, friability, diameter, thickness, hardness and disintegration time) were measured (Ryakala et al, 2015).…”

“…The total weight of each bilayer tablet was adjusted to 300 mg, containing 50 mg of atenolol in immediate release layer and 13.8 mg of amlodipine besilate equivalent to 10 mg of amlodipine in sustain release layer which was tabulated in table 3. Prepared bilayer tablets were evaluated for various post-compression parameters and in vitro dissolution studies (Ryakala et al, 2015). Physical evaluation of bilayer tablets; Formulated bilayer tablets were subjected to various evaluation tests like thickness, hardness, weight variation and friability.…”

“…Initially 10 tablets were weighed (W1) and machine was rotate at 25 rpm for 4 minutes. After removal of fines the tablets were again weighed (W2) and the percentage of weight loss was calculated by the following equation (Ryakala et al, 2015):…”

Determination of Palladium Content in Nebivolol HCl Bulk Drug by ICP-OES

“…Nebivolol is a β1 receptor blocker with nitric oxide potentiating vasodilator effect used in treatment of hypertension and in Europe, also for left ventricular failure [1]. It is highly cardio selective under certain circumstances.…”

СУЧАСНИЙ СТАН СТВОРЕННЯ, ВИРОБНИЦТВА ТА ДОСЛІДЖЕННЯ ТАБЛЕТОВАНИХ ЛІКАРСЬКИХ ПРЕПАРАТІВ Повідомлення 28. Характеристика Процесу Виробництва І Дослідження Багатошарових Таблеток

“…Найбільш ефективним виявилося використання полівінілпіролідону (ПВП) К-30 [14]. Оптимізований склад шару IR (негайного вивільнення) містив натрій крохмальгліколят і забезпечував вивільнення АФІ за 30 хв [15]. Натрій крохмальгліколят забезпечував негайне вивільнення шару лорноксикаму за 30 хв [16].…”