Formulation and Physical Characteristics of Detam Ii Soybean (Glycine Max (L.) Merr) Tablet With Various Concentration of Silicon Dioxide and Magnesium Stearate

Abstract

Objective: This research was conducted to obtain several formulation and evaluate the physical characteristics of the soybean Glycine max (L.) Merr Detam II variety tablets. Methods:Detam II varieties of soybean (G. max (L.) Merr.) were cleaned and grinded into 30 mesh-sized powder. Weighed soybean powder and internal phase of excipients (based on the formula) mixed by a Y-cone mixer until homogeneous, and then continue with dry granulation process. Granules formed, then sieved into 16 mesh size, and then, the characteristics examined. Dried granules then mixed with magnesium stearate and silicon dioxide using a drum mixer and compressed into tablets. Physical characteristics of tablets measured at 0, 4, 7, 14, 21, and 28 days.Results: Evaluation was done for particle size distribution, moisture content (MC), flow properties, weight uniformity, friability, hardness, and disintegration time. Dry granulation was the best method to improve the characteristics of soybean powder with poor compressibility, poor flowability, and hygroscopic. Flow properties of the granules became better for Formula II and III by adding the concentration of silicon dioxide. The formulas also showed the good uniformity of weight, size, MC, friability, and disintegration time. Reducing the lubricant until 0, 5% of the formula made differences in friability, hardness, and disintegration time better than another formula. Conclusion:The result of this research indicates that differences in silicon dioxide and magnesium stearate composition of the formula can affect the physical characteristics of soybean (G. max (L.) Merr.) tablets.

Formulation and Physical Characterization of Black Soybean (Glycine Max L.) Variety of Detam II Tablets with Dry Granulation Method

“…Black soybean (Glycine Max L.) detam II varieties were blended and then sieved using a sieve number 30. The black soybean powder is then stored in a dry place and protected from light (Yulia R., et al, 2018). Black soybean powder and other ingredients such as PVP K30, gelatin, and starch maydis were weighed according to the formula then stirred manually for 15 minutes.…”

“…The resulting tablet size has a diameter of 13 mm with a final weight of 700 mg. Furthermore, the physical test of the black soybean tablet variety Detam II was carried out (Yulia R., et al, 2018). Evaluation of black soybean granule (Glycine Max L.) of detam II variety.…”

“…Flow time is recorded using a stopwatch. A good sample flow time of 100 grams of sample should be able to flow through a 10 mm funnel in less than 11 seconds (Yulia R., et al, 2018). The angle of repose is determined using a special AoR funnel on the test instrument.…”

“…Good flow properties are the main requirements for a material to flow to the printing press for compression. Previous research has made tablets with various concentrations of silicon dioxide and magnesium stearate with PVP K30 as a binder but has not obtained tabet hardness according to the requirements (Yulia R., et al, 2018). This study aims to make a Detam II tablet formula with dry granulation and uses a variety concentration of binders and fillers such as PVP K30, amylum maydis, and gelatin.…”

The Extract Soybean of Local Varieties as Reduce Advanced Glycation End Products and Hemoglobin A1c in Type 2 Diabetes Mice

“…Yulia using other varieties of soybean suggests varying biological activity in decreasing lipid peroxidation activity, potentially as an antioxidant [15]. Further, research conducted by Yulia proving of several varieties of soybean seeds that exist, Argomulyo varieties provide the highest antioxidant effect [16]. The high content of isoflavones in soybeans has also proven to be significantly beneficial for postmenopausal women in terms of increasing levels of collagen, elasticity, and skin epithelial thickness [17].…”