Formulation, characterization and<i>in vitro</i>evaluation of floating microspheres of famotidine as a gastro retentive dosage form

Jain,

doi:10.4103/0973-8398.56302

Cited by 20 publications

(8 citation statements)

References 16 publications

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“…Quantitative determination of nizatidine hydrochloride was carried out after suitable dilution using UV/Visible spectrophotometer (Shimadzu 1800, Japan). The experiment was repeated with the different volume of the solvents to obtain more appropriate degree of solubility [16,17]. The profi le of solubility of nizatidine HcL in different solvent is given in Table 1.…”

Section: Solubility Profi Lementioning

confidence: 99%

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Development and optimization of mucoadhesive microballons of nizatidine for management of peptic ulcer

Jain¹,

Jain²,

Kor³

et al. 2020

Int J Pharm Sci Dev Res

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Ulcers are characterized histologically as a part in the mucosa of the GI tract through the muscularis mucosae into the submucosa or more inside part of GI trat mucous membrane. Ulcer can affect any part of the gastrointestinal tract contact with more secretion of acid peptic juices [1]. The gastric ulcer are generalized into Aphthous ulcers, Esophageal ulcers and Peptic ulcer based on their affected area in gastrointestinal tract in mouth, throat and stomach or the duodenum separately [2]. These are three kinds for example Aphthous ulcers create within the lips and cheeks or underneath the tongue. They are also called aphthae, aphthosis, aphthous stomatitis and infection. Mouth ulcers are generally have family ancestry (up to 40%) and are ordinarily because of injury (in view of not appropriate fi tting of false teeth, broke teeth, or fi llings),anemia, measles, viral contamination, oral candidiasis, incessant diseases, throat malignant growth, mouth malignant growth and vitamin B defi ciency [3,4]. Esophageal ulcers are injuries that happen toward the fi nish of throat because of Gastroesophageal Refl ux Sickness (GERD) with 10 % frequency. They can be produce pain directly underneath the breastbone [5,6]. Peptic ulcer are chronic, frequently develop lesions that happen in any part of the gastrointestinal tract due to the more amount of secretion of acid peptic juices. Peptic ulcer develop in a number of part of the gastrointestinal tract (GIT) which is exposed to gastric acid and pepsin, for example the stomach and duodenum. Peptic ulcers generally induced in rodents by physiological, pharmacological or other surgical medicines which have etiological signifi cance for stimulation of peptic ulcers. A few models are referenced in following which utilized

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Section: Solubility Profi Lementioning

confidence: 99%

“…base to adhere the balloons for increase the retarding of drug release, thus will be effective for drug delivery through oral mucosa for peptic ulcer management [13][14][15]. profi le in various aqueous and nonaqueous solvents, partition coeffi cient and FTIR study [16,17].…”

mentioning

confidence: 99%

Development and optimization of mucoadhesive microballons of nizatidine for management of peptic ulcer

Jain¹,

Jain²,

Kor³

et al. 2020

Int J Pharm Sci Dev Res

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“…All the six formulation of Levofloxacin microspheres were tested for stability studies in stability chamber. Formulation was exposed up to 30 and 60 days of stability studies at 40°C ± 2°C and 75% ± 5% RH [13][14] . 1085…”

Section: Stability Studiesmentioning

confidence: 99%

Formulation and Evaluation of Floating Microspheres of Levofloxacin

Khan¹,

Arora²,

Ojha³

et al. 2018

Int Res J Pharm

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Purpose: The objective of present study is to develop site-specific drug delivery system for controlled release of levofloxacin for eradication of H. pylori for the treatment of peptic ulcer. Methodology: Floating microspheres of Levofloxacin were prepared by solvent evaporation method. The drug was encapsulated with Eudragit and Ethyl cellulose in various combinations of polymers ratios. Findings: The prepared microspheres are subjected to evaluation for particle size, % buoyancy, in-vitro release study and stability studies. The percentage buoyancy was found to be in the range of 67.12% to 94.21%. The good buoyancy behaviour of the microspheres revealed that the microspheres are hollow in nature and retained for more than 12 hr in the upper part of the GIT in order to enhance gastric residence time. Research Implications: The prepared formulations can be tested clinically to assure the in vivo performance. Value of paper: The current study compared the combination of polymers and revealed their effect on drug release and various other parameters for the preparation of floating microspheres.

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“…Materials used for FDDS include carbon dioxide gas-forming agents (carbonate or bicarbonate compounds) 8,13 , highly swellable hydrocolloids and light mineral oils 14,15 . Multiple unit systems and floating systems prepared by solvent evaporation methods have also been developed 12,[16][17][18][19][20] . However, it has been shown that products based on a multiple unit system comprising many small units have advantages over single -unit preparations such as matrix tablets 21 .…”

Section: Introductionmentioning

confidence: 99%

Formulation Development and Evaluation of Floating Microsphere of Famotidine for the Treatment of Peptic Ulcer

Rai¹,

Pandey²,

Jain³

et al. 2019

J. Drug Delivery Ther.

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The purpose of this research was to prepare a floating drug delivery system of famotidine. The floating microspheres can be prepared for the improvement of absorption and bioavailability of famotidine by retaining the system in the stomach for prolonged period of time. Floating microspheres of famotidine were prepared using different polymers like ethyl cellulose, hydroxy propyl methyl cellulose by solvent diffusion-evaporation method. The microspheres had smooth surfaces with free-flowing and good-packing properties. The yield of the microspheres was up to 73.32±0.14% and ethyl cellulose microspheres entrapped the maximum amount of the drug. Scanning electron microscopy confirmed their hollow structures with sizes in 331.6 nm. The prepared microspheres exhibited prolonged drug release and Percentage buoyancy was found to 73.25±0.23. The formulated batches were evaluated for percentage yield, particle size measurement, flow properties, percent entrapment efficiency, swelling studies. The formulations were subjected to stability studies and In-vitro release and release kinetics data was subjected to different dissolution models. It was concluded that developed floating microspheres of famotidine offers a suitable and practical approach for prolonged release of drug over an extended period of time and thus oral bioavailability, efficacy and patient compliance is improved. Keywords: Famotidine, Solvent diffusion evaporation method, Ethyl cellulose, Hydroxyl propyl methyl cellulose

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Formulation, characterization andin vitroevaluation of floating microspheres of famotidine as a gastro retentive dosage form

Cited by 20 publications

References 16 publications

Development and optimization of mucoadhesive microballons of nizatidine for management of peptic ulcer

Development and optimization of mucoadhesive microballons of nizatidine for management of peptic ulcer

Formulation and Evaluation of Floating Microspheres of Levofloxacin

Formulation Development and Evaluation of Floating Microsphere of Famotidine for the Treatment of Peptic Ulcer

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