Formulation and Evaluation of Floating Microspheres of Levofloxacin

Khan, Rukhsar; Arora, Ritika; Ojha, Anup; Chopra, Himansu; Upadhayaya, Kumud

doi:10.7897/2230-8407.097147

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…Stability Study: Stability study was carried out on formulated microspheres after storing at 40 °C and 75% relative humidity for one month according to ICH guidelines 19 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2021

IJPSR

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The present study was aimed to formulate and evaluate floating microspheres of Baclofen. The research work's objective was to retain Baclofen in the stomach for a prolonged period of time, which has absorption window in the upper gastrointestinal tract. The microspheres were prepared by solvent evaporation technique. A 3 2 full factorial was applied to investigate the combined effect of the two independent variables, i.e., the concentration of Eudragit RL100 (X1) and concentration of Eudragit RS 100 (X2) on the dependent variables particle size (Y 1 ), percentage drug entrapment efficiency (Y 2 ), percentage buoyancy (Y3), in-vitro drug release at 1 h (Y4), in-vitro drug release at 6 h (Y 5 ). Results of the multiple regression analysis revealed that in-vitro drug release decreased and particle size, percentage drug entrapment efficiency, percentage buoyancy was increased with increasing the concentration of Eudragit RL100 and Eudragit RS100. The optimized formulation has a particle size of 115.96 µm, percentage drug entrapment of 90.06%, and buoyancy of 90.76%. In-vitro drug release of Baclofen floating microspheres showed a sustained release up to 24 h. The floating microspheres were free-flowing, porous, and almost spherical in shape. The in-vitro drug release kinetics studies revealed that the Higuchi model was followed by the formulation and drug release by fickian diffusion mechanism.

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“…Stability Study: Stability study was carried out on formulated microspheres after storing at 40 °C and 75% relative humidity for one month according to ICH guidelines 19 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2021

IJPSR

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“… Drugs having local action in the stomach: e.g., Levofloxacin 17 , Famotidine 18, Roxatidine acetate HCl 19 .…”

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confidence: 99%

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2020

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Berberine Hydrochloride Embedded Chitosan-based Novel Floating Microspheres: Optimization, Characterization, and in vivo Anti-ulcer Potential

Rani

Kumar

Verma

et al. 2022

DDL

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Background: Microspheres are controlled drug delivery systems (CDDS) because they have the potential to encapsulate various drugs, nucleic acids, and proteins. Their benefits include biocompatiblity, greater bioavailability, and controlled release. Presently, existing antiulcer agents suffer from severe side effects which restricted their utility and encouraged the requirement of a harmless and proficient new antiulcer agent. The rationale of the present research work was to absorb the drug in the stomach for better antiulcer potential and fewer side effects. Objective: The rationale of the current investigational effort is to prepare and examine floating microspheres using berberine hydrochloride to increase gastric retention without interaction with the mucosa inside the stomach. Methods: The capillary extrusion technique was used with the aid of chitosan, a polymer in addition to sodium lauryl sulphate, a crosslinking agent. Scanning electron microscopy characterized the surface morphology of the prepared microspheres. The effects of polymeric concentration as well as the concentration of cross-link agent on percent yield, in vitro floating behavior, and in vitro drug release were efficiently assessed. Results: Diffusion has been observed as a popular mechanism for most launches. Prolonged drug release (12 hrs) has been seen in the prepared microspheres and they also remained buoyant for around 10 hrs. In vivo evaluation study was successfully performed. From the values of ulcer indexes for various groups, percentage protection was determined. The treatment group (F-2 formulation) showed the maximum percentage protection of 97.29%. Conclusion: The prepared floating microspheres can thus persuade potential candidates to be adaptable to any intra-gastric conditions for multiple-unit delivery devices.

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Formulation and Evaluation of Floating Microspheres of Levofloxacin

Cited by 4 publications

References 2 publications

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Berberine Hydrochloride Embedded Chitosan-based Novel Floating Microspheres: Optimization, Characterization, and in vivo Anti-ulcer Potential

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