Formulation of delivery systems with risperidone based on biodegradable terpolymers

Turek, Artur; Borecka, Aleksandra; Janeczek, Henryk; Sobota, Michał; Kasperczyk, Janusz

doi:10.1016/j.ijpharm.2018.06.051

Cited by 13 publications

(31 citation statements)

References 67 publications

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“…In our previous work, εcaprolactone (ε-CL) was introduced into either PLGA chains or poly(d, l-lactide-co-glycolide-co-ε-caprolactone) (poly(DLLA-co-GA-co-CL), abbreviated as PLGC), and PLGC was found to exhibit better elasticity and controlled degradation 22 ; hence, PLGC represents a promising carrier for biodegradable drug-delivery systems. [23][24][25] However, no studies have yet reported the use of a PLGC-based drugdelivery system for the treatment of osteomyelitis.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

Liu

Bai

Liang

2020

Journal of Applied Biomaterials & Functional Materials

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Chronic osteomyelitis causes serious injury to patients. Antibiotic delivery systems based on poly(lactide-co-glycolide) (PLGA) have great potential for treatment of chronic osteomyelitis. However, PLGA has a glass-transition temperature that is higher than physiological temperatures, resulting in a lack of flexibility for implantation into the bone marrow cavity. As an alternative, poly(d, l-lactide-co-glycolide-co-ε-caprolactone) (PLGC) presents good flexibility due to the introduction of poly(ε-caprolactone) segments. To develop a new strategy for treatment of chronic osteomyelitis, a ciprofloxacin delivery system was prepared using PLGC as carriers, the antibacterial effects of which were evaluated both in vivo and in vitro. The in vitro release behavior showed that the average release reached 268.5 μg/days on day 33, with a cumulative release rate of 56.01%. A bacteriostatic ring, with a diameter of 26.83 ± 0.83 mm, was produced by ciprofloxacin against Staphylococcus aureus after 30 days of release via our ciprofloxacin-PLGC system. After 4 weeks of treatment in vivo, chronic-osteomyelitis-model rats had a bodyweight of 385.83 ± 17.23 g and a normal white-blood-cell count, as well as a lower number of bacterial colonies per gram of bone tissue of (10.6 ± 3.0) × 101 CFU/g. Furthermore, no inflammatory cells were observed via hematoxylin-and-eosin staining, and normal bone structure was observed via X-ray. Taken together, our findings indicate that our novel ciprofloxacin-PLGC system yielded noteworthy antibacterial effects both in vitro and in vivo, suggesting that it may be useful for treating patients with chronic osteomyelitis.

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Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

Liu

Bai

Liang

2020

Journal of Applied Biomaterials & Functional Materials

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“…A unique feature of this material is that it returns to its original shape in the temperature of the human body as a result of shape memory effect. This material can be used as a self-expanding stent or a carrier for drug delivery, and it has been widely characterized in terms of synthesis, polymer chain microstructure, thermal properties, and degradation in vivo [ 124 , 125 , 126 , 127 , 128 ].…”

Section: Biodegradable Polyestersmentioning

confidence: 99%

Nonwoven Releasing Propolis as a Potential New Wound Healing Method—A Review

2021

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Wound healing poses a serious therapeutic problem. Methods which accelerate tissue regeneration and minimize or eliminate complications are constantly being sought. This paper is aimed at evaluation of the potential use of biodegradable polymer nonwovens releasing propolis as wound healing dressings, based on the literature data. Propolis is honeybee product with antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, analgesic, and regenerative properties. Controlled release of this substance throughout the healing should promote healing process, reduce the risk of wound infection, and improve aesthetic effect. The use of biodegradable aliphatic polyesters and polyester carbonates as a propolis carrier eliminates the problem of local drug administration and dressing changes. Well-known degradation processes and kinetics of the active substance release allows the selection of the material composition appropriate to the therapy. The electrospinning method allows the production of nonwovens that protect the wound against mechanical damage. Moreover, this processing technique enables adjusting product properties by modifying the production parameters. It can be concluded that biodegradable polymer dressings, releasing a propolis, may find potential application in the treatment of complicated wounds, as they may increase the effectiveness of treatment, as well as improve the patient’s life quality.

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“…Hot melt extrusion (HME) is one of the methods of rod formulation used for the processing of thermoplastic materials [ 9 , 10 , 11 , 12 ]. The flow temperature of polymers was primarily determined empirically.…”

Section: Introductionmentioning

confidence: 99%

“…The flow temperature of polymers was primarily determined empirically. However, it should not exceed the melting temperature ( T m ) of the drug substance [ 9 , 10 ]. In turn, electron beam (EB) irradiation is the sterilization method that is most often used for biomaterials and implantable drug formulations [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of the Mechanical, Structural, and Thermal Properties of Poly(l-lactide-co-glycolide-co-trimethylene carbonate) in the Development of Rods with Aripiprazole

et al. 2021

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In this work, we aimed to determine the role of the mechanical, structural, and thermal properties of poly(l-lactide-co-glycolide-co-trimethylene carbonate) (P(l-LA:GA:TMC)) with shape memory in the formulation of implantable and biodegradable rods with aripiprazole (ARP). Hot melt extrusion (HME) and electron beam (EB) irradiation were applied in the formulation process of blank rods and rods with ARP. Rod degradation was carried out in a PBS solution. HPLC; NMR; DSC; compression and tensile tests; molecular weight (Mn); water uptake (WU); and weight loss (WL) analyses; and SEM were used in this study. HME and EB irradiation did not influence the structure of ARP. The mechanical tests indicated that the rods may be safely implanted using a pre-filled syringe. During degradation, no unfavorable changes in terpolymer content were observed. A decrease in the glass transition temperature and the Mn, and an increase in the WU and the WL were revealed. The loading of ARP and EB irradiation induced earlier pore formation and more intense WU and WL changes. ARP was released in a tri-phasic model with the lag phase; therefore, the proposed formulation may be administered as a delayed-release system. EB irradiation was found to accelerate ARP release.

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Formulation of delivery systems with risperidone based on biodegradable terpolymers

Cited by 13 publications

References 67 publications

In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

Nonwoven Releasing Propolis as a Potential New Wound Healing Method—A Review

The Role of the Mechanical, Structural, and Thermal Properties of Poly(l-lactide-co-glycolide-co-trimethylene carbonate) in the Development of Rods with Aripiprazole

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