Formulation of Red Fruit Oil Nanoemulsion Using Sucrose Palmitate

JUFRI, MAHDI; Iswandana, Raditya; WARDANI, DINA ANGGA; MALIK, SITI FACHRUNNISA

doi:10.22159/ijap.2022v14i5.44314

Cited by 8 publications

(8 citation statements)

References 21 publications

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“…More recently, the red oil ( P. conoideus ) previously reported was formulated by using the NE technique in the form of a conventional NE, a cream NE, and an NE gel, intended for skin application. The NEs were prepared by employing sucrose palmitate as an emulsifying agent and a brute force method using an Ultra-Turrax homogenizer as a high-speed mixer [ 169 ].…”

Section: Nanotechnologymentioning

confidence: 99%

“…The cream NE demonstrated plastic flow properties, and an average particle size of 392 nm, while that in the form of gel revealed plastic flow properties and an average particle size of 144 nm. In antioxidant experiments using the 2.2-diphenyl-1-picrylhydrazyl (DPPH) assay, the cream and gel nanosuspensions showed IC50 values of 6.14 and 48.85, respectively [ 169 ].…”

Section: Nanotechnologymentioning

confidence: 99%

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Development of Phytochemical Delivery Systems by Nano-Suspension and Nano-Emulsion Techniques

Zuccari

Alfei

2023

IJMS

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The awareness of the existence of plant bioactive compounds, namely, phytochemicals (PHYs), with health properties is progressively expanding. Therefore, their massive introduction in the normal diet and in food supplements and their use as natural therapeutics to treat several diseases are increasingly emphasized by several sectors. In particular, most PHYs possessing antifungal, antiviral, anti-inflammatory, antibacterial, antiulcer, anti-cholesterol, hypoglycemic, immunomodulatory, and antioxidant properties have been isolated from plants. Additionally, their secondary modification with new functionalities to further improve their intrinsic beneficial effects has been extensively investigated. Unfortunately, although the idea of exploiting PHYs as therapeutics is amazing, its realization is far from simple, and the possibility of employing them as efficient clinically administrable drugs is almost utopic. Most PHYs are insoluble in water, and, especially when introduced orally, they hardly manage to pass through physiological barriers and scarcely reach the site of action in therapeutic concentrations. Their degradation by enzymatic and microbial digestion, as well as their rapid metabolism and excretion, strongly limits their in vivo activity. To overcome these drawbacks, several nanotechnological approaches have been used, and many nanosized PHY-loaded delivery systems have been developed. This paper, by reporting various case studies, reviews the foremost nanosuspension- and nanoemulsion-based techniques developed for formulating the most relevant PHYs into more bioavailable nanoparticles (NPs) that are suitable or promising for clinical application, mainly by oral administration. In addition, the acute and chronic toxic effects due to exposure to NPs reported so far, the possible nanotoxicity that could result from their massive employment, and ongoing actions to improve knowledge in this field are discussed. The state of the art concerning the actual clinical application of both PHYs and the nanotechnologically engineered PHYs is also reviewed.

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Section: Nanotechnologymentioning

confidence: 99%

Section: Nanotechnologymentioning

confidence: 99%

Development of Phytochemical Delivery Systems by Nano-Suspension and Nano-Emulsion Techniques

Zuccari

Alfei

2023

IJMS

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“…Organoleptic tests were carried out on nanoemulgel, which were visually observed for changes in color, odor, and shape. 14…”

Section: Organoleptic Testmentioning

confidence: 99%

Formulation and effectiveness test of clove flower oil (Syzygium aromaticum L.) nanoemulsigel preparations against Propionibacterium acnes bacteria

Sembiring,

Reveny,

Dalimunthe

2023

Int J Basic Clin Pharmacol

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Background: Acne is a chronic inflammatory process in the pilosebaceous glands. The appearance of acne is a process of follicular hyper-keratinization, which causes blockage of the pores so that the hair follicles are blocked by bacteria known as Propionibacterium acnes. Clove flower oil contains eugenol compounds which have the strongest activity against gram-positive and gram-negative bacteria. Methods: In this research, antibacterial activity tests were carried out on clove flower oil with various concentrations and nano-emulsion gel preparations were made with a clove flower oil concentration of 1.5%; 3%; 5.5%, which was then tested for antibacterial activity on the nano-emulsion gel preparations of clove flower oil measured using a caliper and the diameter of the inhibition zone produced was recorded. Results: the results of the organoleptic research showed that the color was yellow, transparent and had a distinctive odor, homogeneity showed that there were no coarse particles, viscosity was still within the required range, pH showed that the pH was still within the required range of 4.5-6.5, particle size test was below 200 nm, cycling test showed that it was stable during storage at hot and cold temperatures for 6 cycles of P. acnes inhibitory clove flower oil nano-emulsion preparation with a concentration of 1.5%; 3%; 5.% respectively have resistance of 11.60 mm, 13.53 mm, 15.76 mm Conclusions: From the results of the research that has been carried out, it is concluded that clove flower oil can be formulated into a nano-emulsion gel preparation, is stable during cycling tests, and has a particle size below 200 nm. Nano-emulsion gel formulations have the greatest antibacterial activity compared to emulsion gel formulations.

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“…Then the electrode is dipped into the sample, until the instrument shows a constant pH value. According to skin pH, the required pH range is 4.5-6.5 [19].…”

Section: Homogeneity Testmentioning

confidence: 99%

Formulation And Evaluation Of Nanoemulgel Clove Leaf Oil (Sygyzium Aromaticum) (L.) Merr & Perry As Anti-Acne

Dasawanti

Reveny

Sumaiyah

2022

International Journal of Science, Technology & Management

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Acne also known as acne vulgaris, is an inflammatory condition of the polysebaceous layer that is brought on by the buildup of keratin. Active oil glands under the skin cause acne. Androgen hormones function as a stimulant for this activity. Cloves are herbal plants that contain essential oil chemicals. The chemical composition of clove leaf oil is mainly composed of eugenol. Eugenol has pharmacological effects as antibacterial, analgesic and anti-inflammatory. Nanoemulsion is a nanocarrier that gets a lot of attention, because of its small particle size so that it can be thermodynamically stable and can increase drug penetration. Recent advances in nanoemulsion research have created new prospects in a number of industries, including pharmaceuticals, biotechnology, food, and cosmetics. This research was conducted by formulating clove leaf oil into nanoemulgel preparations, followed by evaluation of the preparations and testing of antibacterial activity against acne-causing bacteria. The result of the nanoemulgel formulation is yellow, smells of clove leaf oil, is transparent and homogeneous. Nanoemulgel viscosity 3434-3109 M.Pas, pH 6.15-6.41 and particle size 12.3-13.3 nm. Physical studies of nanoemulgel been carried out for three cycles and there is no change in color, change in odor and phase separation. The results of the antibacterial activity of Staphylococcus epidermidis at NEG1 12.03 mm, NEG2 16.93 mm, NEG3 18.96 mm and EG 18.03 mm. The results of the antibacterial activity of Propionibacterium acnes at NEG1 11.50 mm, NEG2 16.16 mm, NEG3 18.03 mm and EG 17.33 mm. The results of the study concluded that clove leaf oil nanoemulgel with a concentration of 7% was the best formula, because it is stable during storage and has the greatest antibacterial activity compared to emulgel.

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Formulation of Red Fruit Oil Nanoemulsion Using Sucrose Palmitate

Cited by 8 publications

References 21 publications

Development of Phytochemical Delivery Systems by Nano-Suspension and Nano-Emulsion Techniques

Development of Phytochemical Delivery Systems by Nano-Suspension and Nano-Emulsion Techniques

Formulation and effectiveness test of clove flower oil (Syzygium aromaticum L.) nanoemulsigel preparations against Propionibacterium acnes bacteria

Formulation And Evaluation Of Nanoemulgel Clove Leaf Oil (Sygyzium Aromaticum) (L.) Merr & Perry As Anti-Acne

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