Fortschritte auf dem Gebiet des Blutfarbstoffes

The Formation of Bilirubin From Hemoglobin in Vivo*

“…Although earlier investigators have suggested that dipyrrolic compounds, such as mesobilifuscin (7,44) and propentdyopent (44,45), may be normally occurring excretory products of heme metabolism, recent findings have failed to confirm this concept (46). The present experiments constitute strong evidence for the existence of alternate pathways of heme catabolism, but they do not establish the identity of the compounds involved.…”

The Preparation of Crystalline Bilirubin-C14*

“…In the present studies, however, dioxy-dipyrrylmethanes were formed in aqueous alkaline (88,89) and organic solutions of bilirubin in the absence of added hydrogen peroxide or other oxidizing agents (77). This suggests the possibility that a similar breakdown of bilirubin to dipyrrolic compounds may occur in the organism (77,92) or in the excreta (93,94), particularly after exposure to light (95,96). SUMMARY 1.…”

“…Formation of propentdyol)ent (Figure 8), which yields red pentdyopent on reduction in alkali, has been shown to be a group reaction given by a variety of tetrapyrroles on treatment with hydrogen peroxide (13,77). In the present studies, however, dioxy-dipyrrylmethanes were formed in aqueous alkaline (88,89) and organic solutions of bilirubin in the absence of added hydrogen peroxide or other oxidizing agents (77).…”