Four new phenolic compounds from the fruit of <i>Cornus officinalis</i> (Cornaceae) and their anti-inflammatory activity in RAW 264.7 cells

Thu, Nguyen Thi Bich; An, Nguyen Thi Thuy; Vinh, Le Ba; Binh, Bui Thi; Khởi, Nguyễn Minh; Ha, Do Thi

doi:10.1080/14786419.2021.1887865

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…The relative configuration of C-7/C-8 and geometry of the olefinic group C-7 ′ /C-8 ′ were determined to be erythro and Z-forms, respectively, based on the coupling constants of 3 J H-7/H-8 = 5.4 Hz and 3 J H-7 ′ /H-8 ′ = 12.6 Hz. 15,16 Based on these results, compound 1 was determined as a new phenolic glycoside and named scandemide (1) (Figures 1 and 2).…”

Section: Resultsmentioning

confidence: 99%

Two New Nitrogen-Containing Glycosides From Stixis scandens

Yến

Tâm

Thanh

et al. 2023

Natural Product Communications

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Phytochemical investigation of a methanol extract of Stixis scandens stems and leaves led to the isolation of 3 nitrogen-containing compounds (1-3) and 6 phenolics (4-9), which included 2 new glycosides, one a phenolic amide glucoside, scandemide (1), and the other an indole alkaloid glycoside, stixilenin (2). Their structures were elucidated by spectroscopic (1D- and 2D-NMR) and spectrometric (HR-ESI-MS) analyses, and acid hydrolysis. The isolated compounds were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW264.7 cells.

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Section: Resultsmentioning

confidence: 99%

Two New Nitrogen-Containing Glycosides From Stixis scandens

Yến

Tâm

Thanh

et al. 2023

Natural Product Communications

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“…These results were in agreement with those in other plant species. In the fruits of Cornus officinalis (Cornaceae), phenolic compounds could inhibit the development of nitric oxide in RAW 264.7 macrophage cells, which were activated by LPS ( Thu et al, 2021 ). Furthermore, these compounds showed appreciable anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-inflammatory activities of durian (Durio zibethinusMurr.) pulp, seed and peel flour

Charoenphun

Klangbud

2022

PeerJ

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The unripe pulp, inner peel and seed of durian were used in this study. These are generally not considered edible and must be disposed of as waste. However, they are good sources of bioactive compounds. Flour extracts from the unripe pulp, inner peel, and seed of two durian (Durio zibethinus Murr.) varieties, namely, Monthong and Chanee, were analyzed chemically to determine their total phenolic content (TPC), antioxidant, and anti-inflammatory capacities. Chanee pulp (CPu) contained a higher TPC (5285.37 ± 517.65 mg GAE/g) than Monthong pulp (MPu), Monthong peel (MP), Monthong seed (MS), Chanee peel (CP) and Chanee seed (CS) (p = 0.0027, 0.0042, 0.0229, 0.0069 and 0.36), respectively. The antioxidant activity of each durian extract was determined against ABTS, nitric oxide, superoxide, hydroxyl, and metal ions. The results indicated that the pulp, inner peel and seed of these durian varieties had antioxidant capacities. Murine Raw 264.7 macrophages were used to determine the cytotoxicity of the flour extracts. The extract of CS flour had the lowest cytotoxicity followed by MP, CPu, CP, MPu and MS (p = 0.5926, 0.44, 0.3191, 0.1471 and 0.0014), respectively. The anti-inflammatory activity was tested by anti-nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated cells by co-treating the Raw 264.7 cells with each durian flour extract and LPS. The extract of MP flour had the lowest IC50 against NO production, indicating the highest anti-NO production activity followed by CS, CPu, MPu, CP and MS (p = 0.7473, 0.0104, < 0.0001, 0.0002 and < 0.0001, respectively). The information obtained in this study is useful for researchers to explore more durian varieties in Southeast Asia to find bioactive compounds that might be novel nutraceuticals for antioxidant, anti-inflammation and therapeutic functional food.

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“…Pretreatment with 100, 200, and 400 μg/mL COE significantly reduced lipopolysaccharide (LPS)-stimulated protein kinase B (Akt) phosphorylation ( p ≤ 0.003), indicating that the inhibition of protein kinase B (Akt), potentially due to COE treatment, attenuated the inflammatory response induced by LPS in RAW 264.7 macrophages ( 121 ). Furthermore, four novel phenolic compounds derived from C. officinalis fruits displayed inhibitory effects on NO secretion in RAW 264.7 cells and demonstrated some anti-inflammatory activity against RAW 264.7 cells ( 122 ). Given the increasing prevalence of obesity worldwide, which often accompanies various inflammatory diseases, a study explored the combination of C. officinalis with other herbs to obtain potential anti-inflammatory drugs for obesity-related inflammation ( 123 ).…”

Section: Pharmacology Of Cornus Officinalismentioning

confidence: 99%

A comprehensive review of Cornus officinalis: health benefits, phytochemistry, and pharmacological effects for functional drug and food development

Deng,

Liu,

Guo

et al. 2024

Front. Nutr.

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IntroductionCornus officinalis sieb. et zucc, a deciduous tree or shrub, is renowned for its “Cornus flesh” fruit, which is widely acknowledged for its medicinal value when matured and dried. Leveraging C. officinalis as a foundational ingredient opens avenues for the development of environmentally friendly health foods, ranging from beverages and jams to preserves and canned products. Packed with diverse bioactive compounds, this species manifests a spectrum of pharmacological effects, including anti-inflammatory, antioxidant, antidiabetic, immunomodulatory, neuroprotective, and cardiovascular protective properties.MethodsThis study employs CiteSpace visual analysis software and a bibliometric analysis platform, drawing upon the Web of Science (WOS) database for literature spanning the last decade. Through a comprehensive analysis of available literature from WOS and Google Scholar, we present a thorough summary of the health benefits, phytochemistry, active compounds, and pharmacological effects of C. officinalis. Particular emphasis is placed on its potential in developing functional drugs and foods.Results and DiscussionWhile this review enhances our understanding of C. officinalis as a prospective therapeutic agent, its clinical applicability underscores the need for further research and clinical studies to validate findings and establish safe and effective clinical applications.

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Four new phenolic compounds from the fruit of Cornus officinalis (Cornaceae) and their anti-inflammatory activity in RAW 264.7 cells

Cited by 8 publications

References 18 publications

Two New Nitrogen-Containing Glycosides From Stixis scandens

Two New Nitrogen-Containing Glycosides From Stixis scandens

Antioxidant and anti-inflammatory activities of durian (Durio zibethinusMurr.) pulp, seed and peel flour

A comprehensive review of Cornus officinalis: health benefits, phytochemistry, and pharmacological effects for functional drug and food development

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