Foveal avascular zone area after macula-off rhegmatogenous retinal detachment repair: an optical coherence tomography angiography study

Sato, Tatsuhiko; Kanai, Masanori; Busch, Caleb; Wakabayashi, Taku

doi:10.1007/s00417-017-3743-5

Cited by 32 publications

(46 citation statements)

References 8 publications

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“…On the other hand, Woo and Sato did not show any significant change in CFT following macula off retinal reattachment in the early post-operative period, up to 6 months. 17,23 This study showed a significant increase in both BCVA and retinal thickness over the follow-up period with no correlation found between BCVA and retinal thickness measurements except within the 3 mm paracentral temporal quadrant in the ETDRS layout. This correlation was found at the level of all and inner (not outer) retinal layers at 1st and 3rd follow-up (r = −0.545; P < 0.05, r = −0.533; P < 0.05 and r =−0.560; P < 0.05, r = −0.562 P < 0.05, respectively).…”

Section: Discussionmentioning

confidence: 64%

<p>Functional and Structural Outcomes at the Foveal Avascular Zone with Optical Coherence Tomography Following Macula off Retinal Detachment Repair</p>

Maqsood¹,

El‐Alfy²,

Hannon³

et al. 2020

OPTH

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Background: Visual recovery following macula involving rhegmatogenous retinal detachment remains poorly understood. The aim of this work is to correlate the functional and the anatomical changes in retinal vasculature in the foveal avascular zone using optical coherence tomography angiography (OCTA) after successful retinal reattachment repair and correlate this data with retinal thickness and post-operative visual recovery. Methods: A prospective, comparative observational study of 28 eyes of 14 patients with 14 eyes undergoing macula off retinal detachment repair with pars plana vitrectomy, endo-laser and silicone oil-based tamponade compared with 14 fellow healthy eyes at 1, 6 and 12 weeks post-operative period. The study was conducted at the

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Section: Discussionmentioning

confidence: 64%

<p>Functional and Structural Outcomes at the Foveal Avascular Zone with Optical Coherence Tomography Following Macula off Retinal Detachment Repair</p>

Maqsood¹,

El‐Alfy²,

Hannon³

et al. 2020

OPTH

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“…They suggested that the DCP might be vulnerable to tissue hypoxia, and the increase in deep FAZ area might indicate the severity of macular ischemia. On the other hand, Sato et al 21 reported that the superficial and deep FAZ area had no correlation with postoperative BCVA at 1, 3, and 6 months after vitrectomy in macula-off RRD. In the present study, the superficial FAZ area in macula-off RRD 6 months after RRD repair did not differ significantly from that in the fellow eye, and we found no correlation with postoperative BCVA, as Sato et al 21 reported.…”

Section: Discussionmentioning

confidence: 97%

“…Recently, a few studies of postoperative change in RRD have used OCTA to consider the FAZ area. 12,21 Woo et al 12 showed that both the superficial and deep FAZ areas correlated negatively with BCVA in the first 2 months after RRD repair in macula-off RRD patients, and the deep FAZ area in macula-off RD eyes was larger than in macula-on RRD. They suggested that the DCP might be vulnerable to tissue hypoxia, and the increase in deep FAZ area might indicate the severity of macular ischemia.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Wang et al 32 studied 14 eyes with macular-off RRD to investigate OCTA parameters to predict postoperative visual outcomes in macularoff RRD. Woo et al 32 included 34 eyes with RRD, wherein 19 eyes had macula-off RRD, 12 and Sato et al 21 enrolled 22 eyes with macula-off RRD to investigate the correlation between FAZ area and visual outcome. Therefore, this study, despite its small sample size, is still worth comparing with other studies.…”

Section: Discussionmentioning

confidence: 99%

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Changes in Retinal Vessel and Retinal Layer Thickness After Vitrectomy in Retinal Detachment via Swept-Source OCT Angiography

Hong

Cho

Kim

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Citation: Hong EH, Cho H, Kim DR, Kang MH, Shin YU, Seong M. Changes in retinal vessel and retinal layer thickness after vitrectomy in retinal detachment via swept-source OCT angiography. Invest Ophthalmol Vis Sci. 2020;61(2):35. https://doi.org/10.1167/iovs.61.2.35 PURPOSE.To compare postvitrectomy retinal and choroidal vessel density (VD) and retinal layer thickness between eyes with macula-off and macula-on rhegmatogenous retinal detachment (RRD) using swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCTA) and to identify OCTA factors associated with visual outcomes. METHODS.We retrospectively reviewed 31 eyes that underwent pars plana vitrectomy for primary RRD. Eyes with macula-off and macula-on RRD were compared with healthy fellow eyes. Both OCT and OCTA were performed 6 months after surgery, and the maculaoff RRD group was divided into two subgroups according to the presence of an outer retinal defect. The correlations between postoperative best-corrected visual acuity (BCVA) at 6 months and SS-OCT and OCTA measurements were analyzed. RESULTS.Twenty eyes with macula-off RRD and 11 eyes with macula-on RRD were included. In the macula-off RRD group, the central retinal thickness was significantly decreased 6 months postoperatively compared with the fellow eyes (228.9 ± 29.7 μm and 253.6 ± 27.7 μm, P = 0.009). In the outer retinal defect group, the choriocapillaris plexus (CCP) VD was significantly decreased compared with the fellow eyes (56.4% ± 4.8% and 60.2% ± 4.0%, P = 0.026). In the macula-off RRD group, the postoperative BCVA at 6 months correlated significantly with the ratio of the center CCP VD of the detached eyes to that of the fellow eyes (R 2 = 0.207, P = 0.025). CONCLUSIONS.The CCP VD could be related to the anatomical restoration of the outer retinal layer in macula-off RRD. The CCP VD as determined by OCTA could be an indicator of the visual outcome after surgery in macula-off RRD.with macula-off and macula-on RRD using swept-source OCT (SS-OCT) and OCTA and to find OCTA factors related to postoperative visual outcomes.

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“…There have been several studies exploring the OCTA features in eyes with RRD. Sato et al 15 reported that there was a significant correlation between the FAZ area of the SCP and central retinal thickness in eyes treated with vitrectomy for macula-off RRD. However, this study did not analyze the FAZ area or VD of the eyes with RRD and did not show the specific endotamponade used in vitrectomy.…”

Section: Discussionmentioning

confidence: 99%

Foveal Microvascular Structures in Eyes with Silicone Oil Tamponade for Rhegmatogenous Retinal Detachment: A Swept-source Optical Coherence Tomography Angiography Study

Lee

Kim

Lee

et al. 2020

Sci Rep

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Silicone oil (So) is widely used as a long-term intravitreal tamponading agent for rhegmatogenous retinal detachment (RRD) repair. this study investigated the structural changes of the foveal microvasculature using optical coherence tomography angiography (octA) in patients with RRD treated with vitrectomy and So tamponade. thirty-eight patients with unilateral RRD who were treated with vitrectomy and So tamponade and were followed up for ≥3 months after SO removal were included. En face octA images were obtained and foveal avascular zone (fAZ) area and vascular density (VD) were compared between study eyes and unaffected contralateral eyes. The FAZ area in deep capillary plexus (Dcp) was larger (P < 0.001) and the VD in DCP was lower (P = 0.022) in the study eyes than in the fellow eyes. The duration of SO tamponade was significantly correlated with the enlargement of fAZ area (P = 0.034) and reduction of VD in DCP (P = 0.015). These changes could reflect vascular insufficiency in eyes with SO tamponade and may represent a potential explanation for the pathogenesis of retinal thinning and unexplained visual loss. Silicone oil is widely used as a long-term intravitreal tamponading agent in vitreoretinal surgery for the treatment of complex retinal detachments 1. For repairing rhegmatogenous retinal detachment (RRD), silicone oil provides excellent structural support to maintain retinal attachment due to its high viscosity and surface tension. However, the use of silicone oil has been associated with complications including cataract 2 , intraocular pressure (IOP) rise 3 , emulsification of oil with secondary glaucoma 4 , subretinal migration of oil 5 , and band keratopathy 6. Furthermore, unexplained loss of vision has occasionally been reported in association with the use of silicone oil 7-9. Previous studies have reported that visual loss after silicone oil use was associated with a significant reduction in inner retinal thickness in the macular area 10. A more recent study by Lee et al. 11 showed that reduction in thickness is not restricted to the inner retinal layer but also in the outer retinal layer as well. Furthermore, a reduction of the ganglion cell layer, outer plexiform layer, and outer nuclear layer thicknesses is correlated to worse visual outcome. Despite these knowledges, the precise pathogenesis of this complication remains obscure. Optical coherence tomography angiography (OCTA) is a noninvasive imaging modality that provides depth-resolved imaging of retinal vasculature. The brief principle of OCTA involves determining the changes in consecutive B-scans at the same location and comparing the decorrelation signal intensity or amplitude between them. To be precise, the B-scan detects the flow of erythrocytes through retinal blood vessels. The decorrelation analysis by software generates the ultimate result with OCTA image within few seconds. The OCTA improved the visualization of the chorioretinal microvasculature without dye injection and allowed layer-by-layer analysis of the different retinal ...

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Foveal avascular zone area after macula-off rhegmatogenous retinal detachment repair: an optical coherence tomography angiography study

Cited by 32 publications

References 8 publications

<p>Functional and Structural Outcomes at the Foveal Avascular Zone with Optical Coherence Tomography Following Macula off Retinal Detachment Repair</p>

<p>Functional and Structural Outcomes at the Foveal Avascular Zone with Optical Coherence Tomography Following Macula off Retinal Detachment Repair</p>

Changes in Retinal Vessel and Retinal Layer Thickness After Vitrectomy in Retinal Detachment via Swept-Source OCT Angiography

Foveal Microvascular Structures in Eyes with Silicone Oil Tamponade for Rhegmatogenous Retinal Detachment: A Swept-source Optical Coherence Tomography Angiography Study

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