Software Defined Radio (SDR) has the flexibility to modify the characteristics of the receiving and transmitting radio device, without physically adjusting the hardware, due to development in the system. Because of the increasing need for wireless communication applications so as to enable consumers to communicate anywhere through information led to the emergence of many communication devices to include the large amount of applications that every one of the devices needs power and thereby increase the total power. This study confirms that the wireless communication system for secured transmit data, fast and inexpensive; can be done by implementing using Partial Reconfiguration (PR) modern technology in FPGA developing based on SDR. The Speed and performance can be improved. The area also can be decreased. The new Xilinx, Vertex Series FPGA, provides the provision of PR. The power consumption can be reduced by applying power reduction techniques in the blocks. The combination of MATLAB (Simulink and M-file) and Simulink HDL Coder offers flexible capabilities for analysis, design; simulation, implementation, and verification. With all these capabilities, in a single system to reduce the time spent tuning for reducing the algorithms and models during rapid prototyping and experimentation and less time on HDL coding. Contribution/ Originality: This study contributes in the existing literature review for implementing MC-CDMA wireless communication system using Partial Reconfiguration (PR) that is a new technology in FPGA. 1. INTRODUCTION The wireless communications revolution started with the mobile phone at the beginning of the 80's and all the improvements which have led to the multiplication of mobile and wireless communications networks and standards [1]. The 1st Generation (1G) of technology was characterized by analog means voice only; 1G quality was too low and also had connections to low speed, but they effectively offered the inherent easiness of mobile communications. The system used in 1G was Frequency Division Multiple Access (FDMA) [2]. The 2nd Generation (2G) of technology is digital in the United States, most of the devices and services were digital. The spread of digital mobile