Fractional flow reserve: a clinical perspective

Corcoran, David; Hennigan, Barry; Berry, Colin

doi:10.1007/s10554-017-1159-2

Cited by 25 publications

(13 citation statements)

References 101 publications

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“…However, it was not until recent Yunxiao Chang et al, QFR inter-core laboratory analysis years, after the invention of clinically feasible tools, that physiological assessment of coronary blood flow could be adopted to guide interventions. Coronary fractional flow reserve (FFR) acquired by a pressure-wire placed within target coronary vessels can assist in decision making for intermediate lesions during coronary intervention, with proven clinical and economic benefits [2][3][4][5]. A FFR value of ≤ 0.80 indicates a functionally significant stenosis [6].…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of quantitative flow ratio: An inter-core laboratory variability study

Chang

Chen²,

Westra

et al. 2020

Cardiol J.

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Background: Quantitative flow ratio (QFR) is a novel approach to derive fractional flow reserve (FFR) from coronary angiography. This study sought to evaluate the reproducibility of QFR when analyzed in independent core laboratories. Methods: All interrogated vessels in the FAVOR II China Study were separately analyzed using the AngioPlus system (Pulse medical imaging technology, Shanghai) by two independent core laboratories, following the same standard operation procedures. The analysts were blinded to the FFR values and online QFR values. For each interrogated vessel, two identical angiographic image runs were used by two core laboratories for QFR computation. In both core laboratories QFR was successfully obtained in 330 of 332 vessels, in which FFR was available in 328 vessels. Thus, 328 vessels ended in the present statistical analysis. Results: The mean difference in contrast-flow QFR between the two core laboratories was 0.004 ± ± 0.03 (p = 0.040), which was slightly smaller than that between the online analysis and the two core laboratories (0.01 ± 0.05, p < 0.001 and 0.01 ± 0.05, p = 0.038). The mean difference of QFR with respect to FFR were comparable between the two core laboratories (0.002 ± 0.06, p = 0.609, and 0.002 ± ± 0.06, p = 0.531). Receiver operating characteristic curve analysis showed that diagnostic accuracies of QFR analyzed by the two core laboratories were both excellent (area under the curve: 0.970 vs. 0.963, p = 0.142), when using FFR as the reference standard. Conclusions: The present study showed good inter-core laboratory reproducibility of QFR in assessing functionally-significant stenosis. It suggests that QFR analyses can be carried out in different core laboratories if, and only if, highly standardized conditions are maintained.

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Section: Introductionmentioning

confidence: 99%

Reproducibility of quantitative flow ratio: An inter-core laboratory variability study

Chang

Chen²,

Westra

et al. 2020

Cardiol J.

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“…However, the case did not meet the criteria for stent implantation on these indicators. FFR guidance for PCI in patients with UAP can define the culprit vessels and improve prognosis, especially in patients with multi-vessel, diffuse lesions [ 1 ]. For this case, stent implantation was needed according to FFR.…”

Section: Discussionmentioning

confidence: 99%

Flow reserve fraction: the optimal choice in lesion assessing and interventional guiding for patient with unstable angina pectoris and intermediate lesion wrapped with myocardial bridge: a case report

Cong

Zheng

et al. 2021

J Cardiothorac Surg

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Background It is difficult to choose correctly interventional strategy for coronary intermediate lesions combined with myocardial bridge. Endovascular imaging is advocated to guide treatment, but flow reserve fraction (FFR) is not recommended to guide the interventional treatment of myocardial bridge disease because of the inaccurate judgment misled by myocardial bridge. Case presentation In this study, we reported a case of a 56-year-old male patient with unstable angina pectoris (UAP). From his coronary angiography, we found diffuse stenosis near the midsection of the left anterior descending (LAD) branch and the presence of a severe myocardial bridge in the lesion area. We were sure that the LAD was culprit vessel and this lesion was culprit lesion. Both FFR and intravenous ultrasound (IVUS) were performed and the conclusions of them are different. Although stent implantation is not usually recommended in the myocardial bridge area. However, after careful examination, a stent was finally implanted under the precise guidance of FFR. And the patient recovered well up-to now. Conclusions This case illustrates that FFR functional test was complimentary to intravascular imaging test for the coronary intermediate lesion, especially the lesion wrapped with myocardial bridges, both in assessing the lesion and in guiding treatment.

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“…In July 2017 the Topical issue on Emerging concepts on Invasive and Noninvasive Coronary Physiological Assessment was published with a great overview over the various imaging modalities with a total of 15 scientific papers by the experts in this field on invasive and non-invasive flow reserve, flow-pressure relationships, microvascular dysfunction, perfusion imaging and wall shear stress [94][95][96][97][98][99][100][101][102][103][104][105][106][107][108].…”

Section: Topical Issue On Emerging Concepts On Invasive and Noninvasimentioning

confidence: 99%

Cardiovascular imaging 2017 in the International Journal of Cardiovascular Imaging

Reiber

Alaiti

Bezerra

et al. 2018

Int J Cardiovasc Imaging

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Fractional flow reserve: a clinical perspective

Cited by 25 publications

References 101 publications

Reproducibility of quantitative flow ratio: An inter-core laboratory variability study

Reproducibility of quantitative flow ratio: An inter-core laboratory variability study

Flow reserve fraction: the optimal choice in lesion assessing and interventional guiding for patient with unstable angina pectoris and intermediate lesion wrapped with myocardial bridge: a case report

Cardiovascular imaging 2017 in the International Journal of Cardiovascular Imaging

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