Fracture resistance of fiber reinforced composite implant abutments

Etxeberria, Marina; Escuín, Tomás; Lassila, Lippo; Abdulmajeed, Awab; Vinyas, M.; Närhi, Timo

doi:10.1016/j.dental.2014.08.005

Cited by 4 publications

(4 citation statements)

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“…The Ly extract composition comprises compounds that engage in interactions with the chitosan polymer, resulting in alterations to the surface of the membranes in conjunction with variations in chitosan concentration. In contrast to findings from previous studies, the results indicate a reduced level of bacterial adhesion on the CS-Ly membranes examined, in comparison with other materials commonly employed in the production of dental implants, after a 24 h period [97]. These topographic changes of the membrane surfaces also change the contact with the bacteria and make the adhesion different [98].…”

Section: Discussioncontrasting

confidence: 92%

Biocompatibility of Membranes Based on a Mixture of Chitosan and Lythri herba Aqueous Extract

Iancu,

Schröder,

Apetroaei

et al. 2023

Applied Sciences

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In the current context of concern for the improvement and protection of environmental conditions, emphasis is placed on the provision of non-toxic, eco-friendly, renewable biomaterials to replace established chemical substances. Lythri herba is the aerial part of the plant species Lythrum salicaria L., known in the scientific literature especially for its content of tannins and total polyphenols, which highlight its antioxidant, hemostatic, antibacterial and antidiarrheal properties. Chitosan is a biopolymer widely used in industry and medicine due to its abundance in nature, its biodegradability, lack of toxicity and the ease with which it can be transformed into several basic forms (hydrogel, membrane, sponge). The aqueous solutions and membranes obtained in this study by merging these two natural resources were biologically tested in terms of genotoxicity (SOS-Chromo assay), hemolytic activity, thrombin generation activity and bacterial adhesion to reveal outwardly the lack of these properties and their use for medical purposes. The results of the current study attest to the absence of mutagenic and slight hemolyzing properties, thus supporting the possibility of using this extract and membrane in medical and pharmaceutical therapeutic practice. The surface parameters of membranes were examined and important influences at thrombin activity were found. Also, bacterial adhesion results showed a correlation between Lythri herba and chitosan concentrations and membranes’ appearances (swelling, stability). The results show that the membranes could be a promising material for biomedical applications.

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Section: Discussioncontrasting

confidence: 92%

Biocompatibility of Membranes Based on a Mixture of Chitosan and Lythri herba Aqueous Extract

Iancu,

Schröder,

Apetroaei

et al. 2023

Applied Sciences

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“…The same procedure was repeated once again in the following week. These mice were then sacrificed four weeks later [ 22 , 23 ], the dissected gastric tissues were subjected to the colony-forming unit (CFU) assay for examining the degree of bacterial colonization [ 37 , 38 ], i.e., to calculate the number of bacterial colonies per milligram of stomach tissue. H. pylori was detected in cryo-sections by using a specific monoclonal antibody.…”

Section: Resultsmentioning

confidence: 99%

Membrane lipid remodeling eradicates Helicobacter pylori by manipulating the cholesteryl 6'-acylglucoside biosynthesis

Ong,

Jan,

et al. 2024

J Biomed Sci

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Background Helicobacter pylori, the main cause of various gastric diseases, infects approximately half of the human population. This pathogen is auxotrophic for cholesterol which it converts to various cholesteryl α-glucoside derivatives, including cholesteryl 6’-acyl α-glucoside (CAG). Since the related biosynthetic enzymes can be translocated to the host cells, the acyl chain of CAG likely comes from its precursor phosphatidylethanolamine (PE) in the host membranes. This work aims at examining how the acyl chain of CAG and PE inhibits the membrane functions, especially bacterial adhesion. Methods Eleven CAGs that differ in acyl chains were used to study the membrane properties of human gastric adenocarcinoma cells (AGS cells), including lipid rafts clustering (monitored by immunofluorescence with confocal microscopy) and lateral membrane fluidity (by the fluorescence recovery after photobleaching). Cell-based and mouse models were employed to study the degree of bacterial adhesion, the analyses of which were conducted by using flow cytometry and immunofluorescence staining, respectively. The lipidomes of H. pylori, AGS cells and H. pylori–AGS co-cultures were analyzed by Ultraperformance Liquid Chromatography-Tandem Mass Spectroscopy (UPLC-MS/MS) to examine the effect of PE(10:0)2, PE(18:0)2, PE(18:3)2, or PE(22:6)2 treatments. Results CAG10:0, CAG18:3 and CAG22:6 were found to cause the most adverse effect on the bacterial adhesion. Further LC–MS analysis indicated that the treatment of PE(10:0)2 resulted in dual effects to inhibit the bacterial adhesion, including the generation of CAG10:0 and significant changes in the membrane compositions. The initial (1 h) lipidome changes involved in the incorporation of 10:0 acyl chains into dihydro- and phytosphingosine derivatives and ceramides. In contrast, after 16 h, glycerophospholipids displayed obvious increase in their very long chain fatty acids, monounsaturated and polyunsaturated fatty acids that are considered to enhance membrane fluidity. Conclusions The PE(10:0)2 treatment significantly reduced bacterial adhesion in both AGS cells and mouse models. Our approach of membrane remodeling has thus shown great promise as a new anti-H. pylori therapy. Graphical Abstract

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“…The rectangular-shaped cantilever had a force constant of 40 N/m, a resonance frequency of 300 kHz and a tip radius with a curvature of <10 nm. The AFM images were processed using a scanning probe image processor XEI (Park Systems), correcting the plane of the AFM image for any coupling of the lateral plane and the z -axis caused by the instrument [ 43 , 44 ].…”

Section: Methodsmentioning

confidence: 99%

1,3,5-Triazine as Branching Connector for the Construction of Novel Antimicrobial Peptide Dendrimers: Synthesis and Biological Characterization

Sheyi,

Mhlongo,

Jorba

et al. 2024

IJMS

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Peptides displaying antimicrobial properties are being regarded as useful tools to evade and combat antimicrobial resistance, a major public health challenge. Here we have addressed dendrimers, attractive molecules in pharmaceutical innovation and development displaying broad biological activity. Triazine-based dendrimers were fully synthesized in the solid phase, and their antimicrobial activity and some insights into their mechanisms of action were explored. Triazine is present in a large number of compounds with highly diverse biological targets with broad biological activities and could be an excellent branching unit to accommodate peptides. Our results show that the novel peptide dendrimers synthesized have remarkable antimicrobial activity against Gram-negative bacteria (E. coli and P. aeruginosa) and suggest that they may be useful in neutralizing the effect of efflux machinery on resistance.

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Fracture resistance of fiber reinforced composite implant abutments

Cited by 4 publications

References 0 publications

Biocompatibility of Membranes Based on a Mixture of Chitosan and Lythri herba Aqueous Extract

Biocompatibility of Membranes Based on a Mixture of Chitosan and Lythri herba Aqueous Extract

Membrane lipid remodeling eradicates Helicobacter pylori by manipulating the cholesteryl 6'-acylglucoside biosynthesis

1,3,5-Triazine as Branching Connector for the Construction of Novel Antimicrobial Peptide Dendrimers: Synthesis and Biological Characterization

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