Fracture risk prediction on children with Osteogenesis Imperfecta subjected to loads under activity of daily living

Wanna, S. B. C.; Basaruddin, Khairul Salleh; Som, Mohd Hanafi Mat; Sulaiman, Abdul Razak; Shukrimi, A; Khan, S. F.; Majid, M.S. Abdul; Ridzuan, M.J.M.

doi:10.1088/1757-899x/429/1/012004

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…In severe cases, where the stress/strain drastically increases and is expected to be greater than the stress threshold, it was postulated that fracture might occur in that particular area. The authors' previous studies also investigated the similar cases, focusing the OI bone fracture due to load of ADL [11] and different load directions [12].…”

Section: Introductionmentioning

confidence: 99%

Finite Element Prediction on Fracture Load of Femur with Osteogenesis Imperfecta under Various Loading Conditions

Wanna

Basaruddin

Mat

et al. 2022

Applied Bionics and Biomechanics

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Osteogenesis Imperfecta (OI) is an inherited disorder characterized by extreme bone fragility due to collagen defects. It is an incurable disease. Bone fractures can occur frequently without prior notice, especially among children. Early quantitative prediction of fracture loads due to OI tends to alert patients to avoid unnecessary situations or dangerous conditions. This study is aimed at investigating the fracture loads of femur with OI under various types of loading. Ten finite element models of an OI-affected bone were reconstructed from the normal femur with different bowing angles ranging from 7.5 to 30.0°. The boundary conditions were assigned on an OI-affected femoral head under three types of load: medial-lateral impacts, compression-tension, and internal-external torsions, and various loading direction cases that reflect the stance condition. The fracture load was examined based on the load that can cause bone fracture for each case. The results show that the loads bearable by the femur before fracture were decreased with respect to the increase of OI bowing angles in most of the loading cases. The risk of fracture for the femur with OI was directly proportional to the increase of bowing angles in the frontal plane. This study provides new insights on fracture load prediction in OI-affected bone with respect to various loading types, which could help medical personnel for surgical intervention judgement.

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Section: Introductionmentioning

confidence: 99%

Finite Element Prediction on Fracture Load of Femur with Osteogenesis Imperfecta under Various Loading Conditions

Wanna

Basaruddin

Mat

et al. 2022

Applied Bionics and Biomechanics

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“…Furthermore, the finite element analysis can be performed considering both tissues, as shown by [ 31 ]. Moreover, other authors have studied femurs affected with OI from various criteria, for example, the degree of bone deformity [ 28 ], angular variation of the load application [ 29 ], increasing the load value [ 25 , 31 ], and influencing fracture [ 27 ]. A different method to reconstruction by tomography is shown, based on a statistical model of the shape and the appearance (SSAM) and a DXA image of the femur [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a numerical fracture report has been documented in 3D bone models, and various stress analyses on these models have been performed [ 26 , 27 ]. Additionally, other authors have performed numerical simulations to determine the behavior of the femur affected with OI considering particular case studies [ 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Bone Fractures Numerical Analysis in a Femur Affected by Osteogenesis Imperfecta

et al. 2021

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This work presents a non-invasive methodology to obtain a three-dimensional femur model of three-year-old infants affected with Osteogenesis Imperfecta (OI) type III. DICOM® Files of a femur were processed to obtain a finite element model to assess the transverse, the oblique, and the comminuted fractures. The model is evaluated under a normal walking cycle. The loads applied were considered the most critical force generated on the normal walking cycle, and the analyses considered anisotropic bone conditions. The outcome shows stress concentration areas in the central zone of the diaphysis of the femur, and the highest levels of stress occur in the case of the comminuted fracture, while the transverse fracture presents the lowest values. Thus, the method can be helpful for determining the bone fracture behavior of certain pathologies, such as osteogenesis imperfecta, osteopenia, and osteoporosis.

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“…Although there are numerous studies [8−12] on the effect of slope surface activities either walking and running on joint reaction forces have been conducted, however investigation up to joint stresses and strains relatively very few. Finite element analysis (FEA) is a common computational tools to investigate the stress and strain response including for porous materials [13] and bone mechanics [14]. Hence, this study was undertaken to investigate the effect of knee joint reaction forces due to incline-decline walking on stresses and strains of femur bone.…”

Section: *Author For Correspondencementioning

confidence: 99%

Finite element analysis on femur subjected to knee joint forces during incline-decline walking

2022

IJATEE

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Walking is one of the activities that produces a significant magnitude to joint reaction forces and stresses of human bone. Walking on different ground surfaces contribute to the different loads and stresses particularly on femur bone. Other than uneven surfaces, walking on certain slope surfaces could also affect the magnitude of joint forces. Therefore, finite element analysis (FEA) was employed in this study to simulate the effect of walking on different slope angles for both incline-decline towards stress and strain responses of femur bone. A three dimensional (3D) geometrical model of femur was developed and converted to 3D finite element model. The loading conditions and constraints that reflect to walking on different sloped surfaces were applied on femoral head and patellar surface. Failure risk, stress-strain distribution and maximum stress-strain on femur were obtained from the simulation. The results show that the increase of sloped angles contribute to the increase of von Mises stress and strain as well as maximum principal stress and strain. The study provides an additional insight on the risk of injury due to incline-decline walking for certain angle of slopes.

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Fracture risk prediction on children with Osteogenesis Imperfecta subjected to loads under activity of daily living

Cited by 9 publications

References 11 publications

Finite Element Prediction on Fracture Load of Femur with Osteogenesis Imperfecta under Various Loading Conditions

Finite Element Prediction on Fracture Load of Femur with Osteogenesis Imperfecta under Various Loading Conditions

Bone Fractures Numerical Analysis in a Femur Affected by Osteogenesis Imperfecta

Finite element analysis on femur subjected to knee joint forces during incline-decline walking

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