2001
DOI: 10.1523/jneurosci.21-11-j0003.2001
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Free 3-Nitrotyrosine Causes Striatal NeurodegenerationIn Vivo

Abstract: Peroxynitrite formation has been demonstrated in several neurodegenerative disorders; thus far, protein nitration and consequent alterations in protein function are implicated as mechanistic events. Free 3-nitrotyrosine (free-3NT) is also elevated in these settings; a neurotoxic role for this modified amino acid has not been investigated. We tested the hypothesis that free-3NT is neurotoxic in vivo, using a mouse model of striatal degeneration. The neurodegenerative effects of the dopaminergic neurotoxin 6-hyd… Show more

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Cited by 68 publications
(48 citation statements)
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“…Furthermore, MPTP and rotenone lead to complex I dysfunction with increased oxidative modification of proteins and (-synuclein aggregation (343). 6-hydroxydopamine, a neurotoxin, deletes GSH, a potent antioxidant, in brain striatum (305), causing striatal neurodegeneration in vivo (273). GAPDH, a critical enzyme in glycolysis and a protein with many other important functions (71), is also oxidized in sporadic PD (185).…”
Section: Redox Proteomics In Pdmentioning
confidence: 99%
“…Furthermore, MPTP and rotenone lead to complex I dysfunction with increased oxidative modification of proteins and (-synuclein aggregation (343). 6-hydroxydopamine, a neurotoxin, deletes GSH, a potent antioxidant, in brain striatum (305), causing striatal neurodegeneration in vivo (273). GAPDH, a critical enzyme in glycolysis and a protein with many other important functions (71), is also oxidized in sporadic PD (185).…”
Section: Redox Proteomics In Pdmentioning
confidence: 99%
“…The mechanism by which FP15 protects diabetic hearts from dysfunction may involve protection against vascular and myocardial tyrosine nitration, PARP activation, lipid peroxidation, and multiple other mechanisms, as all these mechanisms have previously been linked to diabetic cardiomyopathy as well as to peroxynitrite-induced cardiac injury. Additional mechanisms of peroxynitrite-mediated diabetic cardiac dysfunction may include inhibition of myofibrillar creatine kinase [85] and of succinyl-CoA:3-oxoacid CoAtransferase [27] or activation of metalloproteinases [45,86].…”
Section: Peroxynitrite Neutralization Improves Cardiac and Vascular Dmentioning
confidence: 99%
“…For instance, striatal injection of free 3-nitrotyrosine at concentrations similar to 6-hydroxydopamine, which causes a well described degenerative pathology and a parkinsonian syndrome in rats, induced a selective loss of dopaminergic neurons (Mihm et al, 2001). Although these data suggest that dopaminergic neurons are particularly sensitive to 3-nitrotyrosine, the molecular basis of 3-nitrotyrosine deleterious effects is unknown.…”
Section: Introductionmentioning
confidence: 99%