Free insulin-like growth factor-I and cognitive function in older persons living in community

Mind over hormones; Sex differences in associations of well-being with IGF-I, IGFBP-3 and physical activity in the KORA-Age study

“…Low levels of both IGF-I and IGFBP-3 have been associated with cognitive decline Deak and Sonntag, 2012;Duron et al, 2012;Landi et al, 2007) while high circulating IGF-I has been observed in depressed patients (Deuschle et al, 1997). Intriguingly, antidepressant treatment decreases circulating IGF-I but increases cerebral spinal fluid concentrations of IGF-I which further highlights the importance of elucidating tissue-specific accessibility and actions of IGF-I (Schilling et al, 2011).…”

Donepezil Improves Cognitive Function in Mice by Increasing the Production of Insulin-Like Growth Factor-I in the Hippocampus

“…The impaired spatial learning in mice with low serum levels of IGF-I is reversed by exogenous administration of IGF-I (Trejo et al, 2008). A close correlation has been shown between the plasma IGF-I levels, and cognitive function has been shown in older individuals (Landi et al, 2007). These observations strongly suggest that IGF-I may improve cognitive function by increasing the plasticity and promoting neurogenesis in the hippocampus.…”

Exercise and Mental Health: Many Reasons to Move

“…IGF-1 is also correlated with neurogenesis, since its release starts several processes related to the proliferation of progenitor cells in the subgranular zone. Exercise increases IGF-1 levels, which are diminished in elderly adults with poor cognitive performance [68] . Since strength training increases testosterone and IGF-1 levels, some authors argue that strength training might have an advantage over cardiovascular training.…”