Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol

Serbinova, E. A.; Kagan, Valerian E.; Han, Derick; Packer, Lester

doi:10.1016/0891-5849(91)90033-y

Cited by 571 publications

(334 citation statements)

References 38 publications

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“…however, tocotrienol was found to be more potent as an antioxidant in biological membranes compared with tocopherol due to its chromanol nucleus and unsaturated isoprenoid side chain [46]. Furthermore, previous research has also found that α-and γ-tocotrienol possess higher antioxidant activities compared with α-tocopherol due to their differences in tail structure and also their powerful ability in recycling α-and γ-tocotrienoxyl (chromanoxyl radical) in biological membranes compared with α-tocopherol [32,40]. Therefore, in the TRF supplementation group, the Sod activity and GSh levels were increased due to the utilization of exogenous antioxidants in combating free radicals.…”

Section: Discussionmentioning

confidence: 99%

Fenitrothion Alters Sperm Characteristics in Rats: Ameliorating Effects of Palm Oil Tocotrienol-Rich Fraction

et al. 2014

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Exposure to organophosphate insecticides such as fenitrothion (FNT) in agriculture and public health has been reported to affect sperm quality. Antioxidants may have a potential to reduce spermatotoxic effects induced by organophosphate. The present study was carried out to evaluate the effects of palm oil tocotrienol-rich fraction (TRF) in reducing the detrimental effects occurring in spermatozoa of FNT-treated rats. Adult male Sprague-Dawley rats were divided into four equal groups: a control group and groups of rats treated orally with palm oil TRF (200 mg/kg), FNT (20 mg/kg) and palm oil TRF (200 mg/kg) combined with FNT (20 mg/kg). The sperm characteristics, DNA damage, superoxide dismutase (SOD) activity, and levels of reduced glutathione (GSH), malondialdehyde (MDA), and protein carbonyl (PC) were evaluated. Supplementation with TRF attenuated the detrimental effects of FNT by significantly increasing the sperm counts, motility, and viability and decreased the abnormal sperm morphology. The SOD activity and GSH level were significantly increased, whereas the MDA and PC levels were significantly decreased in the TRF+FNT group compared with the rats receiving FNT alone. TRF significantly decreased the DNA damage in the sperm of FNT-treated rats. A significant correlation between abnormal sperm morphology and DNA damage was found in all groups. TRF showed the potential to reduce the detrimental effects occurring in spermatozoa of FNT-treated rats.

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Section: Discussionmentioning

confidence: 99%

Fenitrothion Alters Sperm Characteristics in Rats: Ameliorating Effects of Palm Oil Tocotrienol-Rich Fraction

et al. 2014

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“…Tocopherols are present in polyunsaturated vegetable oils and in the germ of cereal seeds, whereas tocotrienols are found in the aleurone and subaleurone layers of cereal seeds and in palm oils. It has been reported that α-Toc-3 possessed 40-to 60-fold higher antioxidant activity than α-Toc against ferrous iron/ascorbate-and ferrous iron/NADPH-induced lipid peroxidation in rat liver microsomes 33 and that α-Toc-3 exhibited greater peroxyl radical scavenging potency than α-Toc in liposomal membranes. 34 The antioxidant reaction of α-tocopherol is not a reaction with oxygen.…”

Section: Natural Antioxidantsmentioning

confidence: 99%

Antioxidants: An Overview on the Natural and Synthetic Types

Atta¹,

Mohamed²,

Abdelgawad³

2017

ECB

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“…However, discrepancies still exist on whether T3s are superior to tocopherols in their antioxidant activities, and on the effectiveness ranking order among different isoforms of T3s. It is likely that the apparent antioxidant activities of tocopherols and T3s are dependent on experimental conditions (Kamat et al 1997;Kashiwagi et al 2009;Serbinova et al 1991;Begum and Terao 2002;Yoshida et al 2003). T3-rich fraction supplementation also stimulated immune response in the presence of immunogenic challenge (Radhakrishnan et al 2009;Mahalingam et al 2010) and exhibited potent anti-inflammatory activity by mediating inflammation-related cytokines .…”

Section: Discussionmentioning

confidence: 99%

Metabolism of tocotrienols in animals and synergistic inhibitory actions of tocotrienols with atorvastatin in cancer cells

et al. 2011

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Tocotrienols (T3s), members of the vitamin E family, exhibit potent anti-cancer, anti-oxidative, antiinflammatory, and some other biological activities. To better understand the bioavailability and metabolism of T3s, T3s and their metabolites were identified in urine and fecal samples from mice on diet supplemented with mixed T3s using HPLC/electrochemical detection and liquid chromatography electrospray ionisation mass spectrometry (LC-ESI-MS). Whereas the short-chain metabolites carboxyethyl hydroxychromans (CEHCs) and carboxymethylbutyl hydroxychromans (CMBHCs) were the major metabolites of T3s, several new metabolites with double bonds were also identified. Similar to tocopherols, the majority of T3 metabolites were excreted as sulfate/ glucuronide conjugates in mouse urine. The distribution of c-and d-T3 and c-T3 metabolites were also determined in different organs as well as in urine and fecal samples from mice on diets supplemented with corresponding T3s. The synergistic anti-cancer actions of c-T3 and atorvastatin (ATST) were studied in HT29 and HCT116 colon cancer cell lines. The combination greatly potentiated the ability of each individual agent to inhibit cancer cell growth and to induce cell cycle arrest and apoptosis. The triple combination of c-T3, ATST, and celecoxib exhibited synergistic actions when compared with any double combination plus the third agent. Mechanistic studies revealed that the synergistic actions of c-T3 and ATST could be attributed to their mediation of 3-hydroxy-3-methyl-glutaryl-CoA reductase, and the subsequent inhibition of protein geranylgeranylation. It remains to be determined whether such a synergy occurs in vivo.

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Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol

Cited by 571 publications

References 38 publications

Fenitrothion Alters Sperm Characteristics in Rats: Ameliorating Effects of Palm Oil Tocotrienol-Rich Fraction

Fenitrothion Alters Sperm Characteristics in Rats: Ameliorating Effects of Palm Oil Tocotrienol-Rich Fraction

Antioxidants: An Overview on the Natural and Synthetic Types

Metabolism of tocotrienols in animals and synergistic inhibitory actions of tocotrienols with atorvastatin in cancer cells

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