Free radical scavengers from the aerial parts of Euphorbia petiolata

Nazemiyeh, Hossein; Kazemi, Elham Mohajjel; Zare, Khadijeh; Jodari, Malakeh; Nahar, Lutfun; Sarker, Satyajit D.

doi:10.1007/s11418-009-0382-0

Cited by 22 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Nazemiyeh et al . [33] reported that this compound has a free radical scavenging ability in animals. This was basically attributed to the existence of a phenolic moiety in the structure.…”

Section: Discussionmentioning

confidence: 99%

Anti- and Pro-Lipase Activity of Selected Medicinal, Herbal and Aquatic Plants, and Structure Elucidation of an Anti-Lipase Compound

et al. 2013

View full text Add to dashboard Cite

Plants that help in slowing down the digestion of triacylglycerols (TAGs) in the pancreas and small intestine of humans play an important role in the reduction of obesity. On the other hand, there may be plants or plant parts that stimulate intestinal lipolytic activity, thus contributing to greater TAG assimilation. The aim of this study was to evaluate the aqueous methanolic extracts of ninety eight (98) medicinal, herbal and aquatic plant materials from Malaysia for their effect on porcine pancreatic lipase (PPL) activity and to identify the structure of an anti-lipase compound from one of the sources. The degree of inhibition was also quantified as relative to orlistat activity against PPL (orlistat equivalents). Results revealed that while 19.4% of the extracts were found to have antilipase activity ≥80%, 12% were actually found to promote PPL activity. Twenty two percent (22.4%) exhibited moderate inhibition (41%-80%) and 2% were neutral toward PPL activity. The ripe fruit of Averrhoa carambola and the leaves of Archidendron jiringa (Jack) I.C Nielsen L. (jering), Cynometra cauliflora (nam-nam) and Aleurites moluccana (L.) Willd (candle nut/buah keras) had the highest (100%) anti-lipase activity and are equivalent to 0.11 µg orlistat/mL. Plants that stimulated lipase activity included Pimpinella anisum L. (aniseed/jintan manis), activating the enzyme by 186.5%. Kaempferol 3-O-rhamnoside was isolated from the ethyl acetate fraction of C. cauliflora leaves and found to be an active lipase inhibitor. The structure was elucidated using 1 H-NMR, 13 C-NMR and 2D-NMR analyses.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti- and Pro-Lipase Activity of Selected Medicinal, Herbal and Aquatic Plants, and Structure Elucidation of an Anti-Lipase Compound

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Through of the phytochemical screening were detected alkaloids, flavonoids, and coumarins. Based on the antioxidant activity reported in the literature for alkaloids, flavonoids, and coumarins we can link the presence of these secondary metabolites to the antioxidant activity detected [31, 32]. …”

Section: Discussionmentioning

confidence: 99%

Treatment with Aqueous Extract fromCroton cajucaraBenth Reduces Hepatic Oxidative Stress in Streptozotocin-Diabetic Rats

Rodrigues

Naso

Porawski

et al. 2012

Journal of Biomedicine and Biotechnology

View full text Add to dashboard Cite

Croton cajucara Benth is a plant found in Amazonia, Brazil and the bark and leaf infusion of this plant have been popularly used to treat diabetes and hepatic disorders. The present study was designed to evaluate the oxidative stress as well as the therapeutic effect of Croton cajucara Benth (1.5 mL of the C. cajucara extract i.g.) in rats with streptozotocin-induced diabetes. Croton cajucara Benth was tested as an aqueous extract for its phytochemical composition, and its antioxidant activity in vitro was also evaluated. Lipid peroxidation and superoxide dismutase, catalase, and glutathione reductase activities were measured in the hepatic tissue, as well as the presence activation of p65 (NF-κB), through western blot. Phytochemical screening of Croton cajucara Benth detected the presence of flavonoids, coumarins and alkaloids. The extract exhibited a significant antioxidant activity in the DPPH-scavenging and the hypoxanthine/xanthine oxidase assays. Liver lipid peroxidation increased in diabetic animals followed by a reduction in the Croton-cajucara-Benth-treated group. There was activation of p65 nuclear expression in the diabetic animals, which was attenuated in the animals receiving the Croton cajucara Benth aqueous extract. The liver tissue in diabetic rats showed oxidative alterations related to the streptozotocin treatment. In conclusion the Croton cajucara Benth aqueus extract treatment effectively reduced the oxidative stress and contributed to tissue recovery.

show abstract

“…In addition, sequences from Euphorbia spp. or Manihot esculenta , which accumulate esculetin (Masamoto et al, 2003; Bayoumi et al, 2008a; Nazemiyeh et al, 2009; Shi et al, 2009), showed high similarities. The biosynthetic pathway of simple coumarins containing esculetin in these plants would be elucidated through the functional analysis of these sequences.…”

Section: Quest For the Candidate Sequences Of Ortho-hydroxylases In Pmentioning

confidence: 99%

2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins

Shimizu

2014

Front. Plant Sci.

View full text Add to dashboard Cite

Coumarins are natural plant products that have been the subject of extensive phytochemical and pharmacological research studies in the past few decades. The core structure of coumarins is derived from the respective cinnamates via ortho-hydroxylation of the aromatic ring, trans/cis isomerization, and lactonization. Various substitution patterns of coumarins have been reported, whereas the biosynthesis of coumarins remains elusive. Ortho-hydroxylation is a key step in simple coumarin biosynthesis as a branch point from the lignin biosynthetic pathway. 2-Oxoglutarate-dependent dioxygenases (2OGDs) from plants convert cinnamate derivatives into simple coumarins through the process of ortho-hydroxylation. This review describes the 2OGDs involved in coumarin biosynthesis and their substrate specificities.

show abstract

Free radical scavengers from the aerial parts of Euphorbia petiolata

Cited by 22 publications

References 24 publications

Anti- and Pro-Lipase Activity of Selected Medicinal, Herbal and Aquatic Plants, and Structure Elucidation of an Anti-Lipase Compound

Anti- and Pro-Lipase Activity of Selected Medicinal, Herbal and Aquatic Plants, and Structure Elucidation of an Anti-Lipase Compound

Treatment with Aqueous Extract fromCroton cajucaraBenth Reduces Hepatic Oxidative Stress in Streptozotocin-Diabetic Rats

2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins

Contact Info

Product

Resources

About